MUKB_PASMU
ID MUKB_PASMU Reviewed; 1495 AA.
AC Q9CN36;
DT 16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Chromosome partition protein MukB {ECO:0000255|HAMAP-Rule:MF_01800};
DE AltName: Full=Structural maintenance of chromosome-related protein {ECO:0000255|HAMAP-Rule:MF_01800};
GN Name=mukB {ECO:0000255|HAMAP-Rule:MF_01800}; OrderedLocusNames=PM0609;
OS Pasteurella multocida (strain Pm70).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Pasteurella.
OX NCBI_TaxID=272843;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Pm70;
RX PubMed=11248100; DOI=10.1073/pnas.051634598;
RA May B.J., Zhang Q., Li L.L., Paustian M.L., Whittam T.S., Kapur V.;
RT "Complete genomic sequence of Pasteurella multocida Pm70.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:3460-3465(2001).
CC -!- FUNCTION: Plays a central role in chromosome condensation, segregation
CC and cell cycle progression. Functions as a homodimer, which is
CC essential for chromosome partition. Involved in negative DNA
CC supercoiling in vivo, and by this means organize and compact
CC chromosomes. May achieve or facilitate chromosome segregation by
CC condensation DNA from both sides of a centrally located replisome
CC during cell division. {ECO:0000255|HAMAP-Rule:MF_01800}.
CC -!- SUBUNIT: Homodimerization via its hinge domain. Binds to DNA via its C-
CC terminal region. Interacts, and probably forms a ternary complex, with
CC MukE and MukF via its C-terminal region. The complex formation is
CC stimulated by calcium or magnesium. Interacts with tubulin-related
CC protein FtsZ. {ECO:0000255|HAMAP-Rule:MF_01800}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, nucleoid {ECO:0000255|HAMAP-
CC Rule:MF_01800}. Note=Restricted to the nucleoid region.
CC {ECO:0000255|HAMAP-Rule:MF_01800}.
CC -!- DOMAIN: The hinge domain, which separates the large intramolecular
CC coiled coil regions, allows the homodimerization, forming a V-shaped
CC homodimer. {ECO:0000255|HAMAP-Rule:MF_01800}.
CC -!- SIMILARITY: Belongs to the SMC family. MukB subfamily.
CC {ECO:0000255|HAMAP-Rule:MF_01800}.
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DR EMBL; AE004439; AAK02693.1; -; Genomic_DNA.
DR RefSeq; WP_010906751.1; NC_002663.1.
DR AlphaFoldDB; Q9CN36; -.
DR SMR; Q9CN36; -.
DR STRING; 747.DR93_1439; -.
DR PRIDE; Q9CN36; -.
DR EnsemblBacteria; AAK02693; AAK02693; PM0609.
DR KEGG; pmu:PM0609; -.
DR PATRIC; fig|272843.6.peg.617; -.
DR HOGENOM; CLU_004430_0_0_6; -.
DR OMA; FIAVYQH; -.
DR Proteomes; UP000000809; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-UniRule.
DR GO; GO:0009295; C:nucleoid; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0030261; P:chromosome condensation; IEA:UniProtKB-KW.
DR GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-UniRule.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.70.3500; -; 1.
DR HAMAP; MF_01800; MukB; 1.
DR InterPro; IPR012090; MukB.
DR InterPro; IPR032520; MukB_hinge.
DR InterPro; IPR042501; MukB_hinge_sf.
DR InterPro; IPR007406; MukB_N_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF04310; MukB; 1.
DR Pfam; PF16330; MukB_hinge; 1.
DR PIRSF; PIRSF005246; MukB; 1.
DR SUPFAM; SSF52540; SSF52540; 2.
PE 3: Inferred from homology;
KW ATP-binding; Cell cycle; Cell division; Chromosome partition; Coiled coil;
KW Cytoplasm; DNA condensation; DNA-binding; Nucleotide-binding;
KW Reference proteome.
FT CHAIN 1..1495
FT /note="Chromosome partition protein MukB"
FT /id="PRO_0000068223"
FT REGION 692..809
FT /note="Flexible hinge"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01800"
FT COILED 322..693
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01800"
FT COILED 861..1140
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01800"
FT COILED 1233..1289
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01800"
FT BINDING 60..67
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01800"
SQ SEQUENCE 1495 AA; 171263 MW; 78C5FDBC1D48CE18 CRC64;
MSEELALENL EHVETSVPHT VFSHANSAPR GKFRSLTLIN WNGFFARTFD LDELVTTLSG
GNGAGKSTTM AGFVTALIPD LTLLHFRNTT EAGATSGSRD KGLHGKLRPG VCYAALDTIN
SRNQRVIVGA RLQQVAGRDK KVDIKTFSIQ GLNLAENPTT IFTDVVNERQ ARVLTLNELK
EKIEQAGAQF KQYHSITDYH AMMFDLGIIP KRLRSSSDRS KFYKLIEASL YGGISSAITR
SLRDYLLPEN LGVRKAFQDM ESALRENRMT LEAIKVTQAD RDLFKHLITE TSNYVASDYM
RHANERRGNI ESAVRFRQDW YRARTEQHLS QQRLVELSRE AAELAENEKT LEVDHQSAVD
YLNLVLNALR HQEKIARYQD DVAEITARLE EQKMVVETAT EQLEESQVQV EQVEQEVDQI
RAQLADYQQA LDAQQTRALQ YQQAIAALEK AKTLCGLADL GVKNVEAYHD EFAAHAESLT
EQVLELEQRM SISDAAKSQF DKAYQLVCKV AGEIPRSTAF EQAKVLLRDY PTQKVQAQQT
SQLRAKLHEL EQRYAQQQSA VRLLKEFNQR ANVSLEDAEA LEAYHAEQEA LLEDVSAELS
EQVEQRSTLR QKREQLSALY QDNAKKAPAW LTAQAALERL QDQSGETFAD SQDVMQFMQA
QLVKERELTI ERDQLEQQRQ QLEAQISRLS QPDGSEDARL NVLAERFGGV LLSELYDDVP
IEDAPYFSAL YGPARHAIVV RDLDAVKGQL AQLEECPDDL YLIEGDPTAF DDSVLSAQEL
AHGVVVQVSD RELRYSKFPE IPLFGRAARE QYLEALQQQR DDVTEQHAQR AFDVQKCQRL
HEHFSQFVGL HLALAFQPNP EDVMAEIQQQ RNEIERELNQ FVTTEQQLRI QLDYAKEKMQ
LLNKLIPQLN LIADESLIDR VEECREQLDI AEQDELFIRQ YGATLSQLEP IANTLQSDPE
HYERLKADYE QAISQQKQVQ QRLFALADVL QRKAHFAYEE RVQTENTDLN EQLRAKLDSL
QQQREVQKAQ LQQKQQQFTN YNRVYIELQT SFNNKMQMLQ ELLQEVGELG VRADQGAEER
AKQRRDELHQ VLSDTRQRRH YVEKQLTLIE SEAQSLNARI RKAERDYKTQ RELVVAAKVS
WCVVMRLSRG SDVEKRLNRR EFAYLSADEL RSMSDKALGA LRTAVADNEY LRDSLRLSED
NRKPENKVRF FIAVYQHLRE RIRQDIIKTD DPIDAIEQME IELSRLTDEL TRREQKLAIS
SESVANIMRK TIQREQNRIR MLNQGLQNIA FGQVKSVRLV VNIRDTHAML LDALSGTQEE
YQDLFTDQRM TFSEAIAKLY QRLNPHIDMG QRTAQTIGEE LLDYRNYLDL EVEVYRGADG
WLRAESGALS TGEAIGTGMS ILLMVVQSWE EESRRIRGKD IVPCRLLFLD EAARLDAKSI
STLFELCERL DMQLLIAAPE NISPEKGTTY KLVRKIAGNQ EHVHVVGLRG FGATA
