ID   MUKB_SODGM              Reviewed;        1484 AA.
AC   Q2NU97;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   07-FEB-2006, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Chromosome partition protein MukB {ECO:0000255|HAMAP-Rule:MF_01800};
DE   AltName: Full=Structural maintenance of chromosome-related protein {ECO:0000255|HAMAP-Rule:MF_01800};
GN   Name=mukB {ECO:0000255|HAMAP-Rule:MF_01800}; OrderedLocusNames=SG1003;
OS   Sodalis glossinidius (strain morsitans).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Bruguierivoracaceae; Sodalis.
OX   NCBI_TaxID=343509;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=morsitans;
RX   PubMed=16365377; DOI=10.1101/gr.4106106;
RA   Toh H., Weiss B.L., Perkin S.A.H., Yamashita A., Oshima K., Hattori M.,
RA   Aksoy S.;
RT   "Massive genome erosion and functional adaptations provide insights into
RT   the symbiotic lifestyle of Sodalis glossinidius in the tsetse host.";
RL   Genome Res. 16:149-156(2006).
CC   -!- FUNCTION: Plays a central role in chromosome condensation, segregation
CC       and cell cycle progression. Functions as a homodimer, which is
CC       essential for chromosome partition. Involved in negative DNA
CC       supercoiling in vivo, and by this means organize and compact
CC       chromosomes. May achieve or facilitate chromosome segregation by
CC       condensation DNA from both sides of a centrally located replisome
CC       during cell division. {ECO:0000255|HAMAP-Rule:MF_01800}.
CC   -!- SUBUNIT: Homodimerization via its hinge domain. Binds to DNA via its C-
CC       terminal region. Interacts, and probably forms a ternary complex, with
CC       MukE and MukF via its C-terminal region. The complex formation is
CC       stimulated by calcium or magnesium. Interacts with tubulin-related
CC       protein FtsZ. {ECO:0000255|HAMAP-Rule:MF_01800}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, nucleoid {ECO:0000255|HAMAP-
CC       Rule:MF_01800}. Note=Restricted to the nucleoid region.
CC       {ECO:0000255|HAMAP-Rule:MF_01800}.
CC   -!- DOMAIN: The hinge domain, which separates the large intramolecular
CC       coiled coil regions, allows the homodimerization, forming a V-shaped
CC       homodimer. {ECO:0000255|HAMAP-Rule:MF_01800}.
CC   -!- SIMILARITY: Belongs to the SMC family. MukB subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_01800}.
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DR   EMBL; AP008232; BAE74278.1; -; Genomic_DNA.
DR   RefSeq; WP_011410864.1; NZ_LN854557.1.
DR   AlphaFoldDB; Q2NU97; -.
DR   SMR; Q2NU97; -.
DR   STRING; 343509.SG1003; -.
DR   EnsemblBacteria; BAE74278; BAE74278; SG1003.
DR   KEGG; sgl:SG1003; -.
DR   eggNOG; COG3096; Bacteria.
DR   HOGENOM; CLU_004430_0_0_6; -.
DR   OMA; FIAVYQH; -.
DR   OrthoDB; 331846at2; -.
DR   BioCyc; SGLO343509:SGP1_RS08565-MON; -.
DR   Proteomes; UP000001932; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-UniRule.
DR   GO; GO:0009295; C:nucleoid; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0030261; P:chromosome condensation; IEA:UniProtKB-KW.
DR   GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.70.3500; -; 1.
DR   HAMAP; MF_01800; MukB; 1.
DR   InterPro; IPR012090; MukB.
DR   InterPro; IPR032520; MukB_hinge.
DR   InterPro; IPR042501; MukB_hinge_sf.
DR   InterPro; IPR007406; MukB_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF04310; MukB; 1.
DR   Pfam; PF16330; MukB_hinge; 1.
DR   PIRSF; PIRSF005246; MukB; 1.
DR   SUPFAM; SSF52540; SSF52540; 2.
PE   3: Inferred from homology;
KW   ATP-binding; Cell cycle; Cell division; Chromosome partition; Coiled coil;
KW   Cytoplasm; DNA condensation; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..1484
FT                   /note="Chromosome partition protein MukB"
FT                   /id="PRO_1000069916"
FT   REGION          666..783
FT                   /note="Flexible hinge"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01800"
FT   COILED          338..415
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01800"
FT   COILED          496..604
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01800"
FT   COILED          781..805
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01800"
FT   COILED          835..868
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01800"
FT   COILED          903..1115
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01800"
FT   COILED          1206..1265
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01800"
FT   BINDING         34..41
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01800"
SQ   SEQUENCE   1484 AA;  169134 MW;  B4B4497A1ABAE23D CRC64;
     MIERGKFRSL TLVNWNGFFA RTFDLDALVT TLSGGNGAGK STTMAAFITA LIPDLTLLHF
     RNTTEAGATS GSRDKGLHGK LRAGVCYSAL EVVNSRHQRV LVGVRLQQIA GRDRKVDIKP
     FMIQGLPVKV TPTEILTMTM GDRQARVLPL QELKERVEAI EGVLFKQFNS ITDYHSLMFD
     LGVVPRRLRS SADRSKYYRL IEASLYGGIS SAITRSLRDY LLPENSGVRK AFQDMEAALR
     ENRLTLEAIR VTQSDRDLFK HLISEATAYV AADYMRHANE RRLHLDDALT LRRDVFGSRK
     QLASEQYRHV DMARELAEIS GGESDLETDY QAASDHLNLV QTAMRQQEKI GRYQEDLEEL
     AFRLEEQNEV VAQSAEQQQE NEARLEAAEL EVDELKSQLA DYQQALDVQQ TRAIQFQQAL
     QALDRARELC SLPAMTWEDA APTLAIYKER EQEATERLLG FEQKLNIAEA ASSRFEQAYG
     LVVKIAGQVS RSDAWQTARE LIRDAASQRH QAERLQALRS QLNELEQRLR EQQDAERLLQ
     EFCQRMGQDY PPEELDVVQQ ELEARVETLS ATVSEAGERR LALRQTLEQV TARIEQLTAR
     ALAWLAAQDA LTALSEQSGE ALTSSRQVTD TMQLLLERER ETTVERDEVA GRKRCIEAQI
     ERLSQPGGTD DARLTTLAER FGGVLLSEIY DDVTLDNAPY FSALYGPSHH AIVVPDLSRV
     REQLDGLEDC PDDLYLIEGD PQSFDDNVFG VEELEGAVLV KVADRQWRYS RFPAVPLFGR
     AARESRLENL SAERDVLAER YATLSFDVQK IQRQHQAFSR FIGAHLAVAF EPDPEAEMRT
     LNGRRGELER ELSDHHGQNQ QSRQHYDQAR EGLQLLNRLI PRLGVLLDDT LQDRLETVQA
     DWHDAQEAAR YLSQHQKALD QLEPLVAVLQ SDPEQHEQLR ADYEQAQQTQ RQVRQQAFAL
     TEVVQRRTHF SYSDSAGMLS ENTDLNDKLR QRLERAEAER SQARDALHAH QAQLTQFSQV
     QASLKSSYDA KQDMLKELMQ ELHDIGVQVD ANAEARARER RDQLHMALSQ NRGRRNQLEK
     QLTFCEAEMD ALQKKLRKLE RDYYQTREQV VSAKAGWCSV LRLVKENGVE RRLHRRELAY
     MEAEDLRSMS DKALGALRLA VADNEHLRDV LRLSEDLKRP ERKIQFFIAV YQHLRERIRQ
     DIIRTDDPVE AIEQMEIELN RLTEELTARE QKLAISSKSV ANIIRKTIQR EQNRIRMLNQ
     GLQAVSFGQV KSVRLNVSVR EAHATLLDVL SEQQEQHQDL FSSQRLTFSE ALAKLYQRLN
     PQIDLRQRTP QTVGEELLDY RNYLEIEVEV NRGADGWLRA ESGALSTGEA IGTGMSILVI
     VVQSWEEESS RLRGKDISPC RLLFLDEAAR LDAKSIATLF ELCDRLQMQL IIAAPENISP
     EKGTTYKLVR KVFNNQEHVH VVGLLGFGTE QAAPPSTALT ETDS