MUKB_VIBVU
ID MUKB_VIBVU Reviewed; 1487 AA.
AC Q8DAP8;
DT 16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Chromosome partition protein MukB {ECO:0000255|HAMAP-Rule:MF_01800};
DE AltName: Full=Structural maintenance of chromosome-related protein {ECO:0000255|HAMAP-Rule:MF_01800};
GN Name=mukB {ECO:0000255|HAMAP-Rule:MF_01800}; OrderedLocusNames=VV1_2145;
OS Vibrio vulnificus (strain CMCP6).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC Vibrio.
OX NCBI_TaxID=216895;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CMCP6;
RA Rhee J.H., Kim S.Y., Chung S.S., Kim J.J., Moon Y.H., Jeong H., Choy H.E.;
RT "Complete genome sequence of Vibrio vulnificus CMCP6.";
RL Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Plays a central role in chromosome condensation, segregation
CC and cell cycle progression. Functions as a homodimer, which is
CC essential for chromosome partition. Involved in negative DNA
CC supercoiling in vivo, and by this means organize and compact
CC chromosomes. May achieve or facilitate chromosome segregation by
CC condensation DNA from both sides of a centrally located replisome
CC during cell division. {ECO:0000255|HAMAP-Rule:MF_01800}.
CC -!- SUBUNIT: Homodimerization via its hinge domain. Binds to DNA via its C-
CC terminal region. Interacts, and probably forms a ternary complex, with
CC MukE and MukF via its C-terminal region. The complex formation is
CC stimulated by calcium or magnesium. Interacts with tubulin-related
CC protein FtsZ. {ECO:0000255|HAMAP-Rule:MF_01800}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, nucleoid {ECO:0000255|HAMAP-
CC Rule:MF_01800}. Note=Restricted to the nucleoid region.
CC {ECO:0000255|HAMAP-Rule:MF_01800}.
CC -!- DOMAIN: The hinge domain, which separates the large intramolecular
CC coiled coil regions, allows the homodimerization, forming a V-shaped
CC homodimer. {ECO:0000255|HAMAP-Rule:MF_01800}.
CC -!- SIMILARITY: Belongs to the SMC family. MukB subfamily.
CC {ECO:0000255|HAMAP-Rule:MF_01800}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE016795; AAO10530.1; -; Genomic_DNA.
DR RefSeq; WP_011080024.1; NC_004459.3.
DR AlphaFoldDB; Q8DAP8; -.
DR SMR; Q8DAP8; -.
DR EnsemblBacteria; AAO10530; AAO10530; VV1_2145.
DR KEGG; vvu:VV1_2145; -.
DR HOGENOM; CLU_004430_0_0_6; -.
DR OMA; FIAVYQH; -.
DR Proteomes; UP000002275; Chromosome 1.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-UniRule.
DR GO; GO:0009295; C:nucleoid; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0030261; P:chromosome condensation; IEA:UniProtKB-KW.
DR GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-UniRule.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.70.3500; -; 1.
DR HAMAP; MF_01800; MukB; 1.
DR InterPro; IPR012090; MukB.
DR InterPro; IPR032520; MukB_hinge.
DR InterPro; IPR042501; MukB_hinge_sf.
DR InterPro; IPR007406; MukB_N_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF04310; MukB; 1.
DR Pfam; PF16330; MukB_hinge; 1.
DR PIRSF; PIRSF005246; MukB; 1.
DR SUPFAM; SSF52540; SSF52540; 2.
PE 3: Inferred from homology;
KW ATP-binding; Cell cycle; Cell division; Chromosome partition; Coiled coil;
KW Cytoplasm; DNA condensation; DNA-binding; Nucleotide-binding.
FT CHAIN 1..1487
FT /note="Chromosome partition protein MukB"
FT /id="PRO_0000068231"
FT REGION 667..784
FT /note="Flexible hinge"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01800"
FT COILED 297..426
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01800"
FT COILED 460..666
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01800"
FT COILED 781..806
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01800"
FT COILED 836..1111
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01800"
FT COILED 1210..1266
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01800"
FT BINDING 34..41
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01800"
SQ SEQUENCE 1487 AA; 168947 MW; 97444976EA6CA48C CRC64;
MIERGKYQSL TMVNWNGFFA RTFDIDGLVT TLSGGNGAGK STTMAAFITA LIPDQSLLHF
RNTTEAGSSQ ASRDKGLYGK LQPGACYAAL DVVNSRNQRL LFAVKLQQVA GRDKKVDIKP
FVIQGLPSHV KPTDVLIESV SATQARVRQI NEVKESVAQY EGVQFKSFSS IVDYHAQMFE
FGVIPKKLRN SSDRSKFYRL IEASLYGGIS SAITRSLRDY LLPQNGGVKK AFQDMESALR
ENRMTLEAIK TTQADRDLFK HLITESTNYV AADYMRHANE RHKKLEQSLS LRSELFSSRE
TLIEQNRLLN QVQQELEMLV ESESALEQDY QGASDHLQLV QNALRQQEKI ERYQEDLEEL
NERLEEQSMV VEEAQERVLM AEEQSTVAEN EVDSLKTQLA DYQQALDVQQ TRALQYQQAV
QALEKAKVLL SDSTLTAESA QALVAQLTQS EAEQTQALLA LKHKLDMSSA AAQQFENALK
LVHSIAGQVE RAEASRHAKA AIQQARSAQQ VVQNENQWRA QHRDLERSLN QQNQAQALVA
EYQKAHQVTL DDEVMFEQER ERHHAQLDSL EIALEENREL RSEQRRQEQD LQSDITQLQA
IAPKWIAAND ALEKLREQSG AELADSQSVM SQMQQVLEQE KQLSQAKDKL AERRSQLESE
IERLASPGGS NDPRLKGLAD TLGGVLLSEI YDDITIDDAP YFSAMYGPAR HAIVVSDLSG
IEEKLVELDD CPEDLYIIEG DVDAFDDSSI KAEELEGAVC VRLNDRQMRY SRFPVIPLFG
RAAREQRLEL LRSEREEVVE KHAKAAFDAQ KMQRLFQAFN QFVAEHIQVA FAADPEQALV
IARDKRNQLT RTLAELEAKE LQMRSQIQNS KQALTMLDKL APMMAVISDD TIGERFAELE
EKIAQLADAK QFLGAHAKAV EQLESQLAVL DADPEQFDAL EAQYQSADSQ LQALKKQIFA
LSDLVERRHY FAYADSVDLL SKSSELSEQL KAKLVEAERA RSRYRDELKQ QQEQMNQYNQ
VLASLKSSYQ AKLETVQEFK QELAEFGVSA DEGALERAIR RRDELHERLH TSRSRKSEYE
RTLTSTELGM KELAKRLKKV QKEYVELRTF VVAAKAGWCS VLRLARENDV ERRLHKRELA
YLSAGELRSM SDKSLGALRL AVANNDDLRD ALRLSEDNAR PERKVLFYIA VYQHLRERIR
QDIIHTDDPV EAIEEMEVEL ARLTEELTMR ENRLAISSES VASIIKKTIQ REQNRIRMLN
QGLSNISFGQ VKGVRLNVKV RESHEVLLNG LATQQEQHKD LFETARYTFS EAMAKLFQRV
NPHIDMGQRS PQVLGEELLD YRNYLELSIE VNRGSDGWLQ AESGALSTGE AIGTGQSILL
MVVQSWEEES RRLRSKDIVP CRLLFLDEAA RLDAKSISTL FELCDRLDMQ LLIAAPENIS
PEKGTTYKLV RKVFKDHEHV HVVGLRGFGQ EQKPKSEAQQ MIEEFEA
