ID   MUKB_YERPG              Reviewed;        1485 AA.
AC   A9R7J9;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Chromosome partition protein MukB {ECO:0000255|HAMAP-Rule:MF_01800};
DE   AltName: Full=Structural maintenance of chromosome-related protein {ECO:0000255|HAMAP-Rule:MF_01800};
GN   Name=mukB {ECO:0000255|HAMAP-Rule:MF_01800};
GN   OrderedLocusNames=YpAngola_A1971;
OS   Yersinia pestis bv. Antiqua (strain Angola).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=349746;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Angola;
RX   PubMed=20061468; DOI=10.1128/jb.01518-09;
RA   Eppinger M., Worsham P.L., Nikolich M.P., Riley D.R., Sebastian Y., Mou S.,
RA   Achtman M., Lindler L.E., Ravel J.;
RT   "Genome sequence of the deep-rooted Yersinia pestis strain Angola reveals
RT   new insights into the evolution and pangenome of the plague bacterium.";
RL   J. Bacteriol. 192:1685-1699(2010).
CC   -!- FUNCTION: Plays a central role in chromosome condensation, segregation
CC       and cell cycle progression. Functions as a homodimer, which is
CC       essential for chromosome partition. Involved in negative DNA
CC       supercoiling in vivo, and by this means organize and compact
CC       chromosomes. May achieve or facilitate chromosome segregation by
CC       condensation DNA from both sides of a centrally located replisome
CC       during cell division. {ECO:0000255|HAMAP-Rule:MF_01800}.
CC   -!- SUBUNIT: Homodimerization via its hinge domain. Binds to DNA via its C-
CC       terminal region. Interacts, and probably forms a ternary complex, with
CC       MukE and MukF via its C-terminal region. The complex formation is
CC       stimulated by calcium or magnesium. Interacts with tubulin-related
CC       protein FtsZ. {ECO:0000255|HAMAP-Rule:MF_01800}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, nucleoid {ECO:0000255|HAMAP-
CC       Rule:MF_01800}. Note=Restricted to the nucleoid region.
CC       {ECO:0000255|HAMAP-Rule:MF_01800}.
CC   -!- DOMAIN: The hinge domain, which separates the large intramolecular
CC       coiled coil regions, allows the homodimerization, forming a V-shaped
CC       homodimer. {ECO:0000255|HAMAP-Rule:MF_01800}.
CC   -!- SIMILARITY: Belongs to the SMC family. MukB subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_01800}.
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DR   EMBL; CP000901; ABX85151.1; -; Genomic_DNA.
DR   RefSeq; WP_002211308.1; NZ_CP009935.1.
DR   AlphaFoldDB; A9R7J9; -.
DR   SMR; A9R7J9; -.
DR   GeneID; 66842135; -.
DR   KEGG; ypg:YpAngola_A1971; -.
DR   PATRIC; fig|349746.12.peg.2947; -.
DR   OMA; FIAVYQH; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-UniRule.
DR   GO; GO:0009295; C:nucleoid; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0030261; P:chromosome condensation; IEA:UniProtKB-KW.
DR   GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.70.3500; -; 1.
DR   HAMAP; MF_01800; MukB; 1.
DR   InterPro; IPR012090; MukB.
DR   InterPro; IPR032520; MukB_hinge.
DR   InterPro; IPR042501; MukB_hinge_sf.
DR   InterPro; IPR007406; MukB_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF04310; MukB; 1.
DR   Pfam; PF16330; MukB_hinge; 1.
DR   PIRSF; PIRSF005246; MukB; 1.
DR   SUPFAM; SSF52540; SSF52540; 2.
PE   3: Inferred from homology;
KW   ATP-binding; Cell cycle; Cell division; Chromosome partition; Coiled coil;
KW   Cytoplasm; DNA condensation; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..1485
FT                   /note="Chromosome partition protein MukB"
FT                   /id="PRO_1000187493"
FT   REGION          666..783
FT                   /note="Flexible hinge"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01800"
FT   COILED          337..480
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01800"
FT   COILED          509..605
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01800"
FT   COILED          835..915
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01800"
FT   COILED          977..1116
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01800"
FT   BINDING         34..41
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01800"
SQ   SEQUENCE   1485 AA;  169909 MW;  494D9A090B4A234D CRC64;
     MIERGKFRSL TLVNWNGFFA RTFDLDELVT TLSGGNGAGK STTMAAFVTA LIPDLTLLHF
     RNTTEAGATS GSRDKGLHGK LRAGVCYSTL DVVNSRHQRV VVGVRLQQVA GRDRKVDIKP
     FTIQGLPTAI QPTEILTELV AERQARVLSL PELKERVEAM EGVQFKQFNS ITDYHSLMFD
     LGVIPKRLRS SADRSKFYRL IEASLYGGIS SAITRSLRDY LLPENSGVRK AFQDMEAALR
     ENRMTLEAIR VTQSDRDLFK HLISEATSYV AADYMRHANE RRIHLDSALV LRRDLFSSRK
     QLVTEQYRHV EMSRELAEQS GAESDLETDY QAASDHLNLV QTAMRQQEKI ERYQSDLEEL
     TYRLEEQSEV VSEASEQQAD NEARAEAAEL EVDELKSQLA DYQQALDVQQ TRAIQYQQAL
     QALERARALC QLPELTADNA EEWLETFHAK EQEATESLLQ LEQKLSVADA AHSQFEQAYQ
     LVVNIAGEVS RSEAWQTARE LLRDWPSQQH LAERVQPLRM RLSELEQRLR AQQDAERLLQ
     EFCKRQGNAY QPEELEALQR ELESQVEELS LSVSDAGERR MAMRQELEQL KLKIQELTAR
     APVWLAAQDA LSQLSEQSGE ALEDSRQVTE YMQQLLERER ETTVERDEIA ASKRAIEAQI
     ERLSQPSGAE DARLIALAER FGGVLLSEIY DDVTIDDAPY FSALYGPSRH GIVVPDLSLV
     REHLQGLDDC PEDLYLIEGD PQSFDDSVFA VEEHEKAVVV KIADRQWRYS RYPEVPLFGR
     AARENRLETL YQERDRLAER YATLSFDVQK TQRTHQAFSR FIGSHLAVAF DADPEAEIRL
     LNTRRGEIER ALNAHEDQNQ QQRQQFDQAK EGISALNRLI PLVSLLLDET LTDRVEEITE
     ELAEAQEAAR YIQQHGVSLT KLEPLLSVLQ SDPQQHEQLQ ESYVLAQNSQ RLAKQQAFAL
     TEVVQRRAHF SYTDSAGMLT ENSDLNDKLR QRLEQAEAER TRAREQLRQY QSQFTQYSQV
     LASLKSSYDA KRDMLKELSQ ELVDIGVPAD ANAEARARAR RDELHAALST NRSRRNQLEK
     QLTFCEAEMD SLQKKLRKLE RDYHQIREQV VNAKAGWCAV MRMVKDNGVE RRLHRRELAY
     MDGDELRSMS DKALGALRLA VADNEHLRDV LRLSEDPKRP ERKIQFYIAV YQHLRERIRQ
     DIIRTDDPVE AIEQMEIELG RLTEELTARE QKLAISSKSV SNIIRKTIHR EQNRIRMLNQ
     GLQAVSFGQV KSVRLNVNVR EAHATLLDVL SEQQEQHQDL FNSNRLTFSE ALAKLYQRLN
     PQMDMGQRLP QTIGEELLDY RNYLELEVEV YRGADGWLRA ESGALSTGEA IGTGMSILVM
     VVQSWEEESR RLRGKDISPC RLLFLDEAAR LDAKSIATLF ELCERLEMQL IIAAPENISP
     EKGTTYKLVR KVFQNHEHVH VVGLRGFANE MPSLPPIAAE LQQGG