ID   MUKF_ACTP7              Reviewed;         443 AA.
AC   B3GXC3;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   22-JUL-2008, sequence version 1.
DT   03-AUG-2022, entry version 62.
DE   RecName: Full=Chromosome partition protein MukF {ECO:0000255|HAMAP-Rule:MF_01803};
GN   Name=mukF {ECO:0000255|HAMAP-Rule:MF_01803}; OrderedLocusNames=APP7_0623;
OS   Actinobacillus pleuropneumoniae serotype 7 (strain AP76).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Actinobacillus.
OX   NCBI_TaxID=537457;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AP76;
RA   Linke B., Buettner F., Martinez-Arias R., Goesmann A., Baltes N.,
RA   Tegetmeyer H., Singh M., Gerlach G.F.;
RT   "Genome and proteome analysis of A. pleuropneumoniae serotype 7.";
RL   Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in chromosome condensation, segregation and cell
CC       cycle progression. May participate in facilitating chromosome
CC       segregation by condensation DNA from both sides of a centrally located
CC       replisome during cell division. Not required for mini-F plasmid
CC       partitioning. Probably acts via its interaction with MukB and MukE.
CC       Overexpression results in anucleate cells. It has a calcium binding
CC       activity. {ECO:0000255|HAMAP-Rule:MF_01803}.
CC   -!- SUBUNIT: Interacts, and probably forms a ternary complex, with MukE and
CC       MukB via its C-terminal region. The complex formation is stimulated by
CC       calcium or magnesium. It is required for an interaction between MukE
CC       and MukB. {ECO:0000255|HAMAP-Rule:MF_01803}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, nucleoid {ECO:0000255|HAMAP-
CC       Rule:MF_01803}. Note=Restricted to the nucleoid region.
CC       {ECO:0000255|HAMAP-Rule:MF_01803}.
CC   -!- SIMILARITY: Belongs to the MukF family. {ECO:0000255|HAMAP-
CC       Rule:MF_01803}.
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DR   EMBL; CP001091; ACE61275.1; -; Genomic_DNA.
DR   RefSeq; WP_005600699.1; NC_010939.1.
DR   AlphaFoldDB; B3GXC3; -.
DR   SMR; B3GXC3; -.
DR   EnsemblBacteria; ACE61275; ACE61275; APP7_0623.
DR   KEGG; apa:APP7_0623; -.
DR   HOGENOM; CLU_049853_0_0_6; -.
DR   OMA; AIYNNER; -.
DR   BioCyc; APLE537457:APP7_RS03175-MON; -.
DR   Proteomes; UP000001226; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-UniRule.
DR   GO; GO:0009295; C:nucleoid; IEA:UniProtKB-SubCell.
DR   GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0030261; P:chromosome condensation; IEA:UniProtKB-KW.
DR   GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd16337; MukF_C; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.10.225.40; -; 1.
DR   Gene3D; 1.20.58.590; -; 1.
DR   HAMAP; MF_01803; MukF; 1.
DR   InterPro; IPR005582; Chromosome_partition_MukF.
DR   InterPro; IPR033441; MukF_C.
DR   InterPro; IPR038198; MukF_C_sf.
DR   InterPro; IPR033440; MukF_M.
DR   InterPro; IPR036141; MukF_M_sp.
DR   InterPro; IPR033439; MukF_WHTH.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF03882; KicB; 1.
DR   Pfam; PF17193; MukF_C; 1.
DR   Pfam; PF17192; MukF_M; 1.
DR   PIRSF; PIRSF018282; MukF; 1.
DR   SUPFAM; SSF140570; SSF140570; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
PE   3: Inferred from homology;
KW   Calcium; Cell cycle; Cell division; Chromosome partition; Cytoplasm;
KW   DNA condensation.
FT   CHAIN           1..443
FT                   /note="Chromosome partition protein MukF"
FT                   /id="PRO_1000187496"
FT   REGION          209..237
FT                   /note="Leucine-zipper"
SQ   SEQUENCE   443 AA;  50816 MW;  93C85E178CAB2A57 CRC64;
     MQNELAQTIP ELINWTKERE FSLSLSSDRL AFLLAISIYN NEQTDGELLE SDLIDLFRYV
     SEVFDQSEAT LTQRANNAIN DLVKQRFLNR FSSEFTEGLA IYRITPLGVG VADYYVRQRE
     FSTLRLSIQL SIVADEIQRA SSAAEEGGDE RFWRNNVFAP LKYSVAEIFD SIDLSQRMMD
     ENQHQIRERI AELLSQNWHE AILSCEQLLD ETSGNLRELQ DTLNAAGDKL QAQLLRIQSC
     LIGRDDLDFV DQLIVNLQNK LDRIISWGQQ AIDLWIGYDR HVHKFIRTAI DMDKNRVFGQ
     RLRQSIQDYF NAPWLLYTAK AESLLDLRDD ETMLNETEAV GELPSELEYE SLSDVQEQII
     SVMQAHLAPF RAEGKPIDLG AVLREQLALY PQSRHFDVAR IIVDQAVKLG MASLDSQAVY
     PEWQAINDNG AEVQANVIDQ YNK