ID   MUKF_ACTSZ              Reviewed;         444 AA.
AC   A6VP67;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=Chromosome partition protein MukF {ECO:0000255|HAMAP-Rule:MF_01803};
GN   Name=mukF {ECO:0000255|HAMAP-Rule:MF_01803}; OrderedLocusNames=Asuc_1405;
OS   Actinobacillus succinogenes (strain ATCC 55618 / DSM 22257 / CCUG 43843 /
OS   130Z).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Actinobacillus.
OX   NCBI_TaxID=339671;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 55618 / DSM 22257 / CCUG 43843 / 130Z;
RX   PubMed=21118570; DOI=10.1186/1471-2164-11-680;
RA   McKinlay J.B., Laivenieks M., Schindler B.D., McKinlay A.A.,
RA   Siddaramappa S., Challacombe J.F., Lowry S.R., Clum A., Lapidus A.L.,
RA   Burkhart K.B., Harkins V., Vieille C.;
RT   "A genomic perspective on the potential of Actinobacillus succinogenes for
RT   industrial succinate production.";
RL   BMC Genomics 11:680-680(2010).
CC   -!- FUNCTION: Involved in chromosome condensation, segregation and cell
CC       cycle progression. May participate in facilitating chromosome
CC       segregation by condensation DNA from both sides of a centrally located
CC       replisome during cell division. Not required for mini-F plasmid
CC       partitioning. Probably acts via its interaction with MukB and MukE.
CC       Overexpression results in anucleate cells. It has a calcium binding
CC       activity. {ECO:0000255|HAMAP-Rule:MF_01803}.
CC   -!- SUBUNIT: Interacts, and probably forms a ternary complex, with MukE and
CC       MukB via its C-terminal region. The complex formation is stimulated by
CC       calcium or magnesium. It is required for an interaction between MukE
CC       and MukB. {ECO:0000255|HAMAP-Rule:MF_01803}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, nucleoid {ECO:0000255|HAMAP-
CC       Rule:MF_01803}. Note=Restricted to the nucleoid region.
CC       {ECO:0000255|HAMAP-Rule:MF_01803}.
CC   -!- SIMILARITY: Belongs to the MukF family. {ECO:0000255|HAMAP-
CC       Rule:MF_01803}.
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DR   EMBL; CP000746; ABR74764.1; -; Genomic_DNA.
DR   RefSeq; WP_012073141.1; NC_009655.1.
DR   AlphaFoldDB; A6VP67; -.
DR   SMR; A6VP67; -.
DR   STRING; 339671.Asuc_1405; -.
DR   EnsemblBacteria; ABR74764; ABR74764; Asuc_1405.
DR   KEGG; asu:Asuc_1405; -.
DR   eggNOG; COG3006; Bacteria.
DR   HOGENOM; CLU_049853_0_0_6; -.
DR   OMA; AIYNNER; -.
DR   OrthoDB; 231724at2; -.
DR   Proteomes; UP000001114; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-UniRule.
DR   GO; GO:0009295; C:nucleoid; IEA:UniProtKB-SubCell.
DR   GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0030261; P:chromosome condensation; IEA:UniProtKB-KW.
DR   GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd16337; MukF_C; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.10.225.40; -; 1.
DR   Gene3D; 1.20.58.590; -; 1.
DR   HAMAP; MF_01803; MukF; 1.
DR   InterPro; IPR005582; Chromosome_partition_MukF.
DR   InterPro; IPR033441; MukF_C.
DR   InterPro; IPR038198; MukF_C_sf.
DR   InterPro; IPR033440; MukF_M.
DR   InterPro; IPR036141; MukF_M_sp.
DR   InterPro; IPR033439; MukF_WHTH.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF03882; KicB; 1.
DR   Pfam; PF17193; MukF_C; 1.
DR   Pfam; PF17192; MukF_M; 1.
DR   PIRSF; PIRSF018282; MukF; 1.
DR   SUPFAM; SSF140570; SSF140570; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
PE   3: Inferred from homology;
KW   Calcium; Cell cycle; Cell division; Chromosome partition; Cytoplasm;
KW   DNA condensation; Reference proteome.
FT   CHAIN           1..444
FT                   /note="Chromosome partition protein MukF"
FT                   /id="PRO_1000073660"
FT   REGION          211..239
FT                   /note="Leucine-zipper"
SQ   SEQUENCE   444 AA;  51648 MW;  6FF7BECFCBD4CDAB CRC64;
     MSETSQTIPE LVSWAREREF SLSLNTERLS YLLAIALYNN ERFDGEMQES DLVDIFRHVS
     KEFDQSDNIT TRANNAINDL VKQRFINRFS SEFTDGLSIY RLTPLGVGVS DYYIRQREFS
     ALRLSVQLAI VADEIQRASE SAEEAVRRGE DEYYWRRNVF APLKYSVAEI FDSIDLSQRI
     MDENQQSIKE EIAELLTKDW QAAIASCERL LDETSGNLRE LQDTLNAAGD KLQAQLLRIQ
     DCVMGRNELY FIDQLIVDLQ SKLDRIISWG QQAIDLWIGY DRHVHKFIRT AIDMDKNRVF
     SQRLRQSIHH YFDAPWFLWT AQAERLVDLR DEELTLRDED ALGELPEALE YEQLSDLHDQ
     IVEAMQALLI NHREHNQPID LSLVLKQQLD NYPLSRHFDV ARVIVDQAVR LGMASADLSG
     VYSQWHEIND YGAEVQANVI DEYK