MUKF_ECO57
ID MUKF_ECO57 Reviewed; 440 AA.
AC Q8XDG2;
DT 16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Chromosome partition protein MukF {ECO:0000255|HAMAP-Rule:MF_01803};
GN Name=mukF {ECO:0000255|HAMAP-Rule:MF_01803};
GN OrderedLocusNames=Z1269, ECs1005;
OS Escherichia coli O157:H7.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83334;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX PubMed=11206551; DOI=10.1038/35054089;
RA Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA Blattner F.R.;
RT "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL Nature 409:529-533(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA Shiba T., Hattori M., Shinagawa H.;
RT "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT genomic comparison with a laboratory strain K-12.";
RL DNA Res. 8:11-22(2001).
CC -!- FUNCTION: Involved in chromosome condensation, segregation and cell
CC cycle progression. May participate in facilitating chromosome
CC segregation by condensation DNA from both sides of a centrally located
CC replisome during cell division. Not required for mini-F plasmid
CC partitioning. Probably acts via its interaction with MukB and MukE.
CC Overexpression results in anucleate cells. It has a calcium binding
CC activity. {ECO:0000255|HAMAP-Rule:MF_01803}.
CC -!- SUBUNIT: Interacts, and probably forms a ternary complex, with MukE and
CC MukB via its C-terminal region. The complex formation is stimulated by
CC calcium or magnesium. It is required for an interaction between MukE
CC and MukB. {ECO:0000255|HAMAP-Rule:MF_01803}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, nucleoid {ECO:0000255|HAMAP-
CC Rule:MF_01803}. Note=Restricted to the nucleoid region.
CC {ECO:0000255|HAMAP-Rule:MF_01803}.
CC -!- SIMILARITY: Belongs to the MukF family. {ECO:0000255|HAMAP-
CC Rule:MF_01803}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE005174; AAG55407.1; -; Genomic_DNA.
DR EMBL; BA000007; BAB34428.1; -; Genomic_DNA.
DR PIR; C85618; C85618.
DR PIR; E90754; E90754.
DR RefSeq; NP_309032.1; NC_002695.1.
DR RefSeq; WP_001288845.1; NZ_SWKA01000005.1.
DR AlphaFoldDB; Q8XDG2; -.
DR SMR; Q8XDG2; -.
DR STRING; 155864.EDL933_1185; -.
DR EnsemblBacteria; AAG55407; AAG55407; Z1269.
DR EnsemblBacteria; BAB34428; BAB34428; ECs_1005.
DR GeneID; 917748; -.
DR KEGG; ece:Z1269; -.
DR KEGG; ecs:ECs_1005; -.
DR PATRIC; fig|386585.9.peg.1125; -.
DR eggNOG; COG3006; Bacteria.
DR HOGENOM; CLU_049853_0_0_6; -.
DR OMA; AIYNNER; -.
DR Proteomes; UP000000558; Chromosome.
DR Proteomes; UP000002519; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-UniRule.
DR GO; GO:0009295; C:nucleoid; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0030261; P:chromosome condensation; IEA:UniProtKB-KW.
DR GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-UniRule.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR CDD; cd16337; MukF_C; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 1.10.225.40; -; 1.
DR Gene3D; 1.20.58.590; -; 1.
DR HAMAP; MF_01803; MukF; 1.
DR InterPro; IPR005582; Chromosome_partition_MukF.
DR InterPro; IPR033441; MukF_C.
DR InterPro; IPR038198; MukF_C_sf.
DR InterPro; IPR033440; MukF_M.
DR InterPro; IPR036141; MukF_M_sp.
DR InterPro; IPR033439; MukF_WHTH.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF03882; KicB; 1.
DR Pfam; PF17193; MukF_C; 1.
DR Pfam; PF17192; MukF_M; 1.
DR PIRSF; PIRSF018282; MukF; 1.
DR SUPFAM; SSF140570; SSF140570; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
PE 3: Inferred from homology;
KW Calcium; Cell cycle; Cell division; Chromosome partition; Cytoplasm;
KW DNA condensation; Reference proteome.
FT CHAIN 1..440
FT /note="Chromosome partition protein MukF"
FT /id="PRO_0000211602"
FT REGION 208..236
FT /note="Leucine-zipper"
SQ SEQUENCE 440 AA; 50533 MW; 482926739D59D298 CRC64;
MSEFSQTVPE LVAWARKNDF SISLPVDRLS FLLAVATLNG ERLDGEMSEG ELVDAFRHVS
DAFEQTSETI GVRANNAIND MVRQRLLNRF TSEQAEGNAI YRLTPLGIGI TDYYIRQREF
STLRLSMQLS IVAGELKRAA DAAEEGGDEF HWHRNVYAPL KYSVAEIFDS IDLTQRLMDE
QQQQVKDDIA QLLNKDWRAA ISSCELLLSE TSGTLRELQD TLEAAGDKLQ ANLLRIQDAT
MTHDDLHFVD RLVFDLQSKL DRIISWGQQS IDLWIGYDRH VHKFIRTAID MDKNRVFAQR
LRQSVQTYFD EPWALSYANA DRLLDMRDEE MALRDEEVTG ELPPDLEYEE FNEIREQLAA
IIEEQLAVYK TRQVPLDLGL VVREYLSQYP RARHFDVARI VIDQAVRLGV AQADFTGLPA
KWQPINDYGA KVQAHVIDKY
