MUKF_HAEAE
ID MUKF_HAEAE Reviewed; 443 AA.
AC O30867;
DT 16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 25-MAY-2022, entry version 70.
DE RecName: Full=Chromosome partition protein MukF {ECO:0000255|HAMAP-Rule:MF_01803};
GN Name=mukF {ECO:0000255|HAMAP-Rule:MF_01803};
OS Haemophilus aegyptius.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Haemophilus.
OX NCBI_TaxID=197575;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9628358;
RA Stein D.C., Gunn J.S., Piekarowicz A.;
RT "Sequence similarities between the genes encoding the S.NgoI and HaeII
RT restriction/modification systems.";
RL Biol. Chem. 379:575-578(1998).
CC -!- FUNCTION: Involved in chromosome condensation, segregation and cell
CC cycle progression. May participate in facilitating chromosome
CC segregation by condensation DNA from both sides of a centrally located
CC replisome during cell division. Not required for mini-F plasmid
CC partitioning. Probably acts via its interaction with MukB and MukE.
CC Overexpression results in anucleate cells. It has a calcium binding
CC activity. {ECO:0000255|HAMAP-Rule:MF_01803}.
CC -!- SUBUNIT: Interacts, and probably forms a ternary complex, with MukE and
CC MukB via its C-terminal region. The complex formation is stimulated by
CC calcium or magnesium. It is required for an interaction between MukE
CC and MukB. {ECO:0000255|HAMAP-Rule:MF_01803}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, nucleoid {ECO:0000255|HAMAP-
CC Rule:MF_01803}. Note=Restricted to the nucleoid region.
CC {ECO:0000255|HAMAP-Rule:MF_01803}.
CC -!- SIMILARITY: Belongs to the MukF family. {ECO:0000255|HAMAP-
CC Rule:MF_01803}.
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DR EMBL; AF019752; AAB70828.1; -; Genomic_DNA.
DR AlphaFoldDB; O30867; -.
DR SMR; O30867; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-UniRule.
DR GO; GO:0009295; C:nucleoid; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0030261; P:chromosome condensation; IEA:UniProtKB-KW.
DR GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-UniRule.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR CDD; cd16337; MukF_C; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 1.10.225.40; -; 1.
DR Gene3D; 1.20.58.590; -; 1.
DR HAMAP; MF_01803; MukF; 1.
DR InterPro; IPR005582; Chromosome_partition_MukF.
DR InterPro; IPR033441; MukF_C.
DR InterPro; IPR038198; MukF_C_sf.
DR InterPro; IPR033440; MukF_M.
DR InterPro; IPR036141; MukF_M_sp.
DR InterPro; IPR033439; MukF_WHTH.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF03882; KicB; 1.
DR Pfam; PF17193; MukF_C; 1.
DR Pfam; PF17192; MukF_M; 1.
DR PIRSF; PIRSF018282; MukF; 1.
DR SUPFAM; SSF140570; SSF140570; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
PE 3: Inferred from homology;
KW Calcium; Cell cycle; Cell division; Chromosome partition; Cytoplasm;
KW DNA condensation.
FT CHAIN 1..443
FT /note="Chromosome partition protein MukF"
FT /id="PRO_0000211604"
FT REGION 211..239
FT /note="Leucine-zipper"
SQ SEQUENCE 443 AA; 51302 MW; 5ADB10F6BBE9D9B4 CRC64;
MIETSQTIPE LVSWAKDREF SLNLPTERLV FLLAIAIYNN ERLDGEMLEA DLVDIFRHTM
NAFEQSTDAI ATRANNAINE LVNNVVNRFS SEFTEGLAIY RLTPLGVGVS DYYIRQREFS
ALRLSVQLSI VADEIQRASD SAEEGVENNE SEHFWRRNVF APLKYSVAEI FDSIDLSQRI
MDENQQSIKD EIAELLTKDW QAAISSCERL LDETSGNLRE LQDTLNAAGD KLQAQLLRIQ
DCVIGRDDLY FIDQLITDLQ SKLDRIISWG QQAIDLWIGY DRHVHKFIRT AIDMDKNRVF
SQRLRNSIHH YFDHPWFLWT AQAERLVDLR DEEMVLREDD ALGELPEELQ YESLSDLHDQ
IVEHMQGLLI AYRENNRPID LSLVLKEQLE NYPLSRHFDV ARIIVDQAVR LGMANDDLSG
IYPDWQAINK RGAEVQAHVI DKY
