ID   MUKF_HAEDU              Reviewed;         443 AA.
AC   Q7VL94;
DT   16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   25-MAY-2022, entry version 109.
DE   RecName: Full=Chromosome partition protein MukF {ECO:0000255|HAMAP-Rule:MF_01803};
GN   Name=mukF {ECO:0000255|HAMAP-Rule:MF_01803}; OrderedLocusNames=HD_1585;
OS   Haemophilus ducreyi (strain 35000HP / ATCC 700724).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=233412;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=35000HP / ATCC 700724;
RA   Munson R.S. Jr., Ray W.C., Mahairas G., Sabo P., Mungur R., Johnson L.,
RA   Nguyen D., Wang J., Forst C., Hood L.;
RT   "The complete genome sequence of Haemophilus ducreyi.";
RL   Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in chromosome condensation, segregation and cell
CC       cycle progression. May participate in facilitating chromosome
CC       segregation by condensation DNA from both sides of a centrally located
CC       replisome during cell division. Not required for mini-F plasmid
CC       partitioning. Probably acts via its interaction with MukB and MukE.
CC       Overexpression results in anucleate cells. It has a calcium binding
CC       activity. {ECO:0000255|HAMAP-Rule:MF_01803}.
CC   -!- SUBUNIT: Interacts, and probably forms a ternary complex, with MukE and
CC       MukB via its C-terminal region. The complex formation is stimulated by
CC       calcium or magnesium. It is required for an interaction between MukE
CC       and MukB. {ECO:0000255|HAMAP-Rule:MF_01803}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, nucleoid {ECO:0000255|HAMAP-
CC       Rule:MF_01803}. Note=Restricted to the nucleoid region.
CC       {ECO:0000255|HAMAP-Rule:MF_01803}.
CC   -!- SIMILARITY: Belongs to the MukF family. {ECO:0000255|HAMAP-
CC       Rule:MF_01803}.
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DR   EMBL; AE017143; AAP96365.1; -; Genomic_DNA.
DR   RefSeq; WP_010945397.1; NC_002940.2.
DR   PDB; 3EUJ; X-ray; 3.10 A; B=292-443.
DR   PDB; 3EUK; X-ray; 4.00 A; E/J=292-443.
DR   PDBsum; 3EUJ; -.
DR   PDBsum; 3EUK; -.
DR   AlphaFoldDB; Q7VL94; -.
DR   SMR; Q7VL94; -.
DR   IntAct; Q7VL94; 2.
DR   STRING; 233412.HD_1585; -.
DR   EnsemblBacteria; AAP96365; AAP96365; HD_1585.
DR   KEGG; hdu:HD_1585; -.
DR   eggNOG; COG3006; Bacteria.
DR   HOGENOM; CLU_049853_0_0_6; -.
DR   OMA; AIYNNER; -.
DR   EvolutionaryTrace; Q7VL94; -.
DR   Proteomes; UP000001022; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-UniRule.
DR   GO; GO:0009295; C:nucleoid; IEA:UniProtKB-SubCell.
DR   GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0030261; P:chromosome condensation; IEA:UniProtKB-KW.
DR   GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd16337; MukF_C; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.10.225.40; -; 1.
DR   Gene3D; 1.20.58.590; -; 1.
DR   HAMAP; MF_01803; MukF; 1.
DR   InterPro; IPR005582; Chromosome_partition_MukF.
DR   InterPro; IPR033441; MukF_C.
DR   InterPro; IPR038198; MukF_C_sf.
DR   InterPro; IPR033440; MukF_M.
DR   InterPro; IPR036141; MukF_M_sp.
DR   InterPro; IPR033439; MukF_WHTH.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF03882; KicB; 1.
DR   Pfam; PF17193; MukF_C; 1.
DR   Pfam; PF17192; MukF_M; 1.
DR   PIRSF; PIRSF018282; MukF; 1.
DR   SUPFAM; SSF140570; SSF140570; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Calcium; Cell cycle; Cell division; Chromosome partition;
KW   Cytoplasm; DNA condensation; Reference proteome.
FT   CHAIN           1..443
FT                   /note="Chromosome partition protein MukF"
FT                   /id="PRO_0000211605"
FT   REGION          209..237
FT                   /note="Leucine-zipper"
FT   HELIX           357..372
FT                   /evidence="ECO:0007829|PDB:3EUJ"
FT   HELIX           379..386
FT                   /evidence="ECO:0007829|PDB:3EUJ"
FT   TURN            387..389
FT                   /evidence="ECO:0007829|PDB:3EUJ"
FT   HELIX           392..394
FT                   /evidence="ECO:0007829|PDB:3EUJ"
FT   HELIX           395..408
FT                   /evidence="ECO:0007829|PDB:3EUJ"
FT   HELIX           414..417
FT                   /evidence="ECO:0007829|PDB:3EUJ"
FT   STRAND          424..426
FT                   /evidence="ECO:0007829|PDB:3EUJ"
FT   TURN            427..430
FT                   /evidence="ECO:0007829|PDB:3EUJ"
FT   STRAND          431..434
FT                   /evidence="ECO:0007829|PDB:3EUJ"
SQ   SEQUENCE   443 AA;  50905 MW;  EDDED14614BAE956 CRC64;
     MQNELAQTIP ELISWTKERE FSLSLPSDRL AFLLVISIYN NEQTDGELLE SDLIDLFRYV
     SNVFEQSEAS LLQRANNAIN DLVKQRFLNR FSSEFTEGLA IYRVTPLGVG VSDYYVRQRE
     FSSLRLSIQL SIVADEIQRA SVAAEQGGDE RYWRNNVFAP LKFSVAEIFD SIDLSQRMMD
     ENQHQIREQI AGLLSQNWHE AIINCQQLLD ETSINLRELQ DTLNAAGDKL QSQLLRIQSC
     LISRDDLAFV DQLIVNLQNK LDRIMSWGQQ AIDLWIGYDK HVHKFIRTAI DMDKNRVFGQ
     RLRQSIQNYF SSPWLLYTAK AEALLDLRDD EAMLNEMEAV GELPMALEYE SLTDVQTQIV
     TAIQAELAHF RDTAQPINLG AVLREQLARY PQSRHFDVAR IIVDQAVKLG MASQDHQAVY
     PVWQPIDDFS AAVQAHLIDQ YDK