ID   MUKF_HAEIG              Reviewed;         444 AA.
AC   A5UEK6;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   10-JUL-2007, sequence version 1.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=Chromosome partition protein MukF {ECO:0000255|HAMAP-Rule:MF_01803};
GN   Name=mukF {ECO:0000255|HAMAP-Rule:MF_01803};
GN   OrderedLocusNames=CGSHiGG_00540;
OS   Haemophilus influenzae (strain PittGG).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=374931;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PittGG;
RX   PubMed=17550610; DOI=10.1186/gb-2007-8-6-r103;
RA   Hogg J.S., Hu F.Z., Janto B., Boissy R., Hayes J., Keefe R., Post J.C.,
RA   Ehrlich G.D.;
RT   "Characterization and modeling of the Haemophilus influenzae core and
RT   supragenomes based on the complete genomic sequences of Rd and 12 clinical
RT   nontypeable strains.";
RL   Genome Biol. 8:R103.1-R103.18(2007).
CC   -!- FUNCTION: Involved in chromosome condensation, segregation and cell
CC       cycle progression. May participate in facilitating chromosome
CC       segregation by condensation DNA from both sides of a centrally located
CC       replisome during cell division. Not required for mini-F plasmid
CC       partitioning. Probably acts via its interaction with MukB and MukE.
CC       Overexpression results in anucleate cells. It has a calcium binding
CC       activity. {ECO:0000255|HAMAP-Rule:MF_01803}.
CC   -!- SUBUNIT: Interacts, and probably forms a ternary complex, with MukE and
CC       MukB via its C-terminal region. The complex formation is stimulated by
CC       calcium or magnesium. It is required for an interaction between MukE
CC       and MukB. {ECO:0000255|HAMAP-Rule:MF_01803}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, nucleoid {ECO:0000255|HAMAP-
CC       Rule:MF_01803}. Note=Restricted to the nucleoid region.
CC       {ECO:0000255|HAMAP-Rule:MF_01803}.
CC   -!- SIMILARITY: Belongs to the MukF family. {ECO:0000255|HAMAP-
CC       Rule:MF_01803}.
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DR   EMBL; CP000672; ABQ99211.1; -; Genomic_DNA.
DR   RefSeq; WP_011962043.1; NC_009567.1.
DR   AlphaFoldDB; A5UEK6; -.
DR   SMR; A5UEK6; -.
DR   EnsemblBacteria; ABQ99211; ABQ99211; CGSHiGG_00540.
DR   KEGG; hiq:CGSHiGG_00540; -.
DR   HOGENOM; CLU_049853_0_0_6; -.
DR   OMA; AIYNNER; -.
DR   Proteomes; UP000001990; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-UniRule.
DR   GO; GO:0009295; C:nucleoid; IEA:UniProtKB-SubCell.
DR   GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0030261; P:chromosome condensation; IEA:UniProtKB-KW.
DR   GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd16337; MukF_C; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.10.225.40; -; 1.
DR   Gene3D; 1.20.58.590; -; 1.
DR   HAMAP; MF_01803; MukF; 1.
DR   InterPro; IPR005582; Chromosome_partition_MukF.
DR   InterPro; IPR033441; MukF_C.
DR   InterPro; IPR038198; MukF_C_sf.
DR   InterPro; IPR033440; MukF_M.
DR   InterPro; IPR036141; MukF_M_sp.
DR   InterPro; IPR033439; MukF_WHTH.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF03882; KicB; 1.
DR   Pfam; PF17193; MukF_C; 1.
DR   Pfam; PF17192; MukF_M; 1.
DR   PIRSF; PIRSF018282; MukF; 1.
DR   SUPFAM; SSF140570; SSF140570; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
PE   3: Inferred from homology;
KW   Calcium; Cell cycle; Cell division; Chromosome partition; Cytoplasm;
KW   DNA condensation.
FT   CHAIN           1..444
FT                   /note="Chromosome partition protein MukF"
FT                   /id="PRO_1000069933"
FT   REGION          212..240
FT                   /note="Leucine-zipper"
SQ   SEQUENCE   444 AA;  51529 MW;  EE6D20ADF4BBF0D0 CRC64;
     MIETSQTIPE LVSWAKDREF SLNLPTERLV FLLAIAIYNN ERLDGEMLEA DLVDIFRHTM
     NAFEQSTDAI ATRANNAINE LVKQRLLNRF SSEFTEGLAI YRLTPLGVGV SDYYIRQREF
     SALRLSVQLS IVADEIQRAS DSAEEGVENN ESEHYWRRNV FAPLKYSVAE IFDSIDLSQR
     IMDENQQSIK NEIAELLTKD WQAAISSCER LLDETSGNLR ELQDTLNAAG DKLQAQLLRI
     QDCVIGRDDL YFIDQLITDL QSKLDRIISW GQQAIDLWIG YDRHVHKFIR TAIDMDKNRV
     FSQRLRNSIH HYFDHPWFLW TAQAERLVDL RDEEMVLRED DALGELPEEL QYESLSDLHD
     QIVEHMQGLL IAYRENNRPI DLSLVLKEQL ENYPLSRHFD VARIIVDQAV RLGMANDDLS
     GIYPDWQAIN KRGAEVQAHV IDKY