ID   MUKF_HAEIN              Reviewed;         444 AA.
AC   P45185;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   16-JAN-2004, sequence version 2.
DT   03-AUG-2022, entry version 119.
DE   RecName: Full=Chromosome partition protein MukF {ECO:0000255|HAMAP-Rule:MF_01803};
GN   Name=mukF {ECO:0000255|HAMAP-Rule:MF_01803}; Synonyms=kicB;
GN   OrderedLocusNames=HI_1372;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
CC   -!- FUNCTION: Involved in chromosome condensation, segregation and cell
CC       cycle progression. May participate in facilitating chromosome
CC       segregation by condensation DNA from both sides of a centrally located
CC       replisome during cell division. Not required for mini-F plasmid
CC       partitioning. Probably acts via its interaction with MukB and MukE.
CC       Overexpression results in anucleate cells. It has a calcium binding
CC       activity. {ECO:0000255|HAMAP-Rule:MF_01803}.
CC   -!- SUBUNIT: Interacts, and probably forms a ternary complex, with MukE and
CC       MukB via its C-terminal region. The complex formation is stimulated by
CC       calcium or magnesium. It is required for an interaction between MukE
CC       and MukB. {ECO:0000255|HAMAP-Rule:MF_01803}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, nucleoid {ECO:0000255|HAMAP-
CC       Rule:MF_01803}. Note=Restricted to the nucleoid region.
CC       {ECO:0000255|HAMAP-Rule:MF_01803}.
CC   -!- SIMILARITY: Belongs to the MukF family. {ECO:0000255|HAMAP-
CC       Rule:MF_01803}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAC23020.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; L42023; AAC23020.1; ALT_INIT; Genomic_DNA.
DR   PIR; B64120; B64120.
DR   RefSeq; NP_439524.2; NC_000907.1.
DR   RefSeq; WP_010869195.1; NC_000907.1.
DR   AlphaFoldDB; P45185; -.
DR   SMR; P45185; -.
DR   STRING; 71421.HI_1372; -.
DR   EnsemblBacteria; AAC23020; AAC23020; HI_1372.
DR   KEGG; hin:HI_1372; -.
DR   PATRIC; fig|71421.8.peg.1427; -.
DR   eggNOG; COG3006; Bacteria.
DR   HOGENOM; CLU_049853_0_0_6; -.
DR   PhylomeDB; P45185; -.
DR   BioCyc; HINF71421:G1GJ1-1398-MON; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-UniRule.
DR   GO; GO:0009295; C:nucleoid; IEA:UniProtKB-SubCell.
DR   GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0030261; P:chromosome condensation; IEA:UniProtKB-KW.
DR   GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd16337; MukF_C; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.10.225.40; -; 1.
DR   Gene3D; 1.20.58.590; -; 1.
DR   HAMAP; MF_01803; MukF; 1.
DR   InterPro; IPR005582; Chromosome_partition_MukF.
DR   InterPro; IPR033441; MukF_C.
DR   InterPro; IPR038198; MukF_C_sf.
DR   InterPro; IPR033440; MukF_M.
DR   InterPro; IPR036141; MukF_M_sp.
DR   InterPro; IPR033439; MukF_WHTH.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF03882; KicB; 1.
DR   Pfam; PF17193; MukF_C; 1.
DR   Pfam; PF17192; MukF_M; 1.
DR   PIRSF; PIRSF018282; MukF; 1.
DR   SUPFAM; SSF140570; SSF140570; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
PE   3: Inferred from homology;
KW   Calcium; Cell cycle; Cell division; Chromosome partition; Cytoplasm;
KW   DNA condensation; Reference proteome.
FT   CHAIN           1..444
FT                   /note="Chromosome partition protein MukF"
FT                   /id="PRO_0000211606"
FT   REGION          212..240
FT                   /note="Leucine-zipper"
SQ   SEQUENCE   444 AA;  51557 MW;  CC67916DC0D18759 CRC64;
     MIETSQTIPE LVSWAKDREF SLNLPTERLV FLLAIAIYNN ERLDGEMLEA DLVDIFRHTM
     NAFEQSTDAI ATRANNAINE LVKQRLLNRF SSEFTEGLAI YRLTPLGVGV SDYYIRQREF
     SALRLSVQLS IVADEIQRAS DSAEEGVENN ENEHYWRRNV FAPLKYSVAE IFDSIDLSQR
     IMDENQQSIK DEIAELLTKD WQAAISSCER LLDETSGNLR ELQDTLNAAG DKLQAQLLRI
     QDCVIGRDDL YFIDQLITDL QSKLDRIISW GQQAIDLWIG YDRHVHKFIR TAIDMDKNRV
     FSQRLRNSIH HYFDHPWFLW TAQAERLVDL RDEEMVLRED DALGELPEEL QYESLSDLHD
     QIVEHMQGLL IAYRENNRPI DLSLVLKEQL ENYPLSRHFD VARIIVDQAV RLGMANDDLS
     GIYPDWQAIN KRGAEVQAHV IDKY