MUKF_SALTI
ID MUKF_SALTI Reviewed; 440 AA.
AC Q8Z7Z7;
DT 16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 25-MAY-2022, entry version 112.
DE RecName: Full=Chromosome partition protein MukF {ECO:0000255|HAMAP-Rule:MF_01803};
GN Name=mukF {ECO:0000255|HAMAP-Rule:MF_01803};
GN OrderedLocusNames=STY0994, t1942;
OS Salmonella typhi.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=90370;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CT18;
RX PubMed=11677608; DOI=10.1038/35101607;
RA Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J.,
RA Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M.,
RA Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A.,
RA Davis P., Davies R.M., Dowd L., White N., Farrar J., Feltwell T.,
RA Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K., Krogh A.,
RA Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C., Quail M.A.,
RA Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S.,
RA Barrell B.G.;
RT "Complete genome sequence of a multiple drug resistant Salmonella enterica
RT serovar Typhi CT18.";
RL Nature 413:848-852(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700931 / Ty2;
RX PubMed=12644504; DOI=10.1128/jb.185.7.2330-2337.2003;
RA Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V.,
RA Kodoyianni V., Schwartz D.C., Blattner F.R.;
RT "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and
RT CT18.";
RL J. Bacteriol. 185:2330-2337(2003).
CC -!- FUNCTION: Involved in chromosome condensation, segregation and cell
CC cycle progression. May participate in facilitating chromosome
CC segregation by condensation DNA from both sides of a centrally located
CC replisome during cell division. Not required for mini-F plasmid
CC partitioning. Probably acts via its interaction with MukB and MukE.
CC Overexpression results in anucleate cells. It has a calcium binding
CC activity. {ECO:0000255|HAMAP-Rule:MF_01803}.
CC -!- SUBUNIT: Interacts, and probably forms a ternary complex, with MukE and
CC MukB via its C-terminal region. The complex formation is stimulated by
CC calcium or magnesium. It is required for an interaction between MukE
CC and MukB. {ECO:0000255|HAMAP-Rule:MF_01803}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, nucleoid {ECO:0000255|HAMAP-
CC Rule:MF_01803}. Note=Restricted to the nucleoid region.
CC {ECO:0000255|HAMAP-Rule:MF_01803}.
CC -!- SIMILARITY: Belongs to the MukF family. {ECO:0000255|HAMAP-
CC Rule:MF_01803}.
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DR EMBL; AL513382; CAD05392.1; -; Genomic_DNA.
DR EMBL; AE014613; AAO69557.1; -; Genomic_DNA.
DR RefSeq; NP_455478.1; NC_003198.1.
DR RefSeq; WP_001288827.1; NZ_WSUR01000013.1.
DR AlphaFoldDB; Q8Z7Z7; -.
DR SMR; Q8Z7Z7; -.
DR STRING; 220341.16502154; -.
DR EnsemblBacteria; AAO69557; AAO69557; t1942.
DR KEGG; stt:t1942; -.
DR KEGG; sty:STY0994; -.
DR PATRIC; fig|220341.7.peg.1002; -.
DR eggNOG; COG3006; Bacteria.
DR HOGENOM; CLU_049853_0_0_6; -.
DR OMA; AIYNNER; -.
DR Proteomes; UP000000541; Chromosome.
DR Proteomes; UP000002670; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-UniRule.
DR GO; GO:0009295; C:nucleoid; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0030261; P:chromosome condensation; IEA:UniProtKB-KW.
DR GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-UniRule.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR CDD; cd16337; MukF_C; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 1.10.225.40; -; 1.
DR Gene3D; 1.20.58.590; -; 1.
DR HAMAP; MF_01803; MukF; 1.
DR InterPro; IPR005582; Chromosome_partition_MukF.
DR InterPro; IPR033441; MukF_C.
DR InterPro; IPR038198; MukF_C_sf.
DR InterPro; IPR033440; MukF_M.
DR InterPro; IPR036141; MukF_M_sp.
DR InterPro; IPR033439; MukF_WHTH.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF03882; KicB; 1.
DR Pfam; PF17193; MukF_C; 1.
DR Pfam; PF17192; MukF_M; 1.
DR PIRSF; PIRSF018282; MukF; 1.
DR SUPFAM; SSF140570; SSF140570; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
PE 3: Inferred from homology;
KW Calcium; Cell cycle; Cell division; Chromosome partition; Cytoplasm;
KW DNA condensation.
FT CHAIN 1..440
FT /note="Chromosome partition protein MukF"
FT /id="PRO_0000211609"
FT REGION 208..236
FT /note="Leucine-zipper"
SQ SEQUENCE 440 AA; 50475 MW; 15595E76810C6964 CRC64;
MSEFSQTVPE LVAWARKNDF SISLPVDRLS FLLAVATLNG ERLDGEMSEG ELVDAFRHVS
DAFEQTSETI GVRANNAIND MVRQRLLNRF TSEQAEGNAI YRLTPLGIGI TDYYIRQREF
STLRLSMQLS IVAGELKRAA DAAAEGGDEF HWHRNVYAPL KYSVAEIFDS IDLTQRIMDE
QQQQVKDDIA QLLNKDWRAA ISSCELLLSE TSGTLRELQD TLEAAGDKLQ ANLLRIQDAT
MTHDDLHFVD RLVFDLQSKL DRIISWGQQS IDLWIGYDRH VHKFIRTAID MDKNRIFAQR
LRQSVQTYFD DPWALTYANA DRLLDMRDEE MALRDDEVTG ELPPDLEYEE FNEIREQLAA
IIEEQLAIYK TRQTPLDLGL VVREYLAQYP RARHFDVARI VIDQAVRLGV AQADFTGLPA
KWQPINDYGA KVQAHVIDKY
