MUKF_SHIFL
ID MUKF_SHIFL Reviewed; 440 AA.
AC P60294; P36567;
DT 16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT 16-JAN-2004, sequence version 1.
DT 25-MAY-2022, entry version 114.
DE RecName: Full=Chromosome partition protein MukF {ECO:0000255|HAMAP-Rule:MF_01803};
GN Name=mukF {ECO:0000255|HAMAP-Rule:MF_01803};
GN OrderedLocusNames=SF0918, S0982;
OS Shigella flexneri.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Shigella.
OX NCBI_TaxID=623;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=301 / Serotype 2a;
RX PubMed=12384590; DOI=10.1093/nar/gkf566;
RA Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT through comparison with genomes of Escherichia coli K12 and O157.";
RL Nucleic Acids Res. 30:4432-4441(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT "Complete genome sequence and comparative genomics of Shigella flexneri
RT serotype 2a strain 2457T.";
RL Infect. Immun. 71:2775-2786(2003).
CC -!- FUNCTION: Involved in chromosome condensation, segregation and cell
CC cycle progression. May participate in facilitating chromosome
CC segregation by condensation DNA from both sides of a centrally located
CC replisome during cell division. Not required for mini-F plasmid
CC partitioning. Probably acts via its interaction with MukB and MukE.
CC Overexpression results in anucleate cells. It has a calcium binding
CC activity. {ECO:0000255|HAMAP-Rule:MF_01803}.
CC -!- SUBUNIT: Interacts, and probably forms a ternary complex, with MukE and
CC MukB via its C-terminal region. The complex formation is stimulated by
CC calcium or magnesium. It is required for an interaction between MukE
CC and MukB. {ECO:0000255|HAMAP-Rule:MF_01803}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, nucleoid {ECO:0000255|HAMAP-
CC Rule:MF_01803}. Note=Restricted to the nucleoid region.
CC {ECO:0000255|HAMAP-Rule:MF_01803}.
CC -!- SIMILARITY: Belongs to the MukF family. {ECO:0000255|HAMAP-
CC Rule:MF_01803}.
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DR EMBL; AE005674; AAN42547.1; -; Genomic_DNA.
DR EMBL; AE014073; AAP16433.1; -; Genomic_DNA.
DR RefSeq; NP_706840.1; NC_004337.2.
DR RefSeq; WP_001288850.1; NZ_WPGW01000072.1.
DR AlphaFoldDB; P60294; -.
DR SMR; P60294; -.
DR STRING; 198214.SF0918; -.
DR EnsemblBacteria; AAN42547; AAN42547; SF0918.
DR EnsemblBacteria; AAP16433; AAP16433; S0982.
DR GeneID; 1023853; -.
DR GeneID; 66670802; -.
DR KEGG; sfl:SF0918; -.
DR KEGG; sfx:S0982; -.
DR PATRIC; fig|198214.7.peg.1069; -.
DR HOGENOM; CLU_049853_0_0_6; -.
DR OMA; AIYNNER; -.
DR OrthoDB; 231724at2; -.
DR Proteomes; UP000001006; Chromosome.
DR Proteomes; UP000002673; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-UniRule.
DR GO; GO:0009295; C:nucleoid; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0030261; P:chromosome condensation; IEA:UniProtKB-KW.
DR GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-UniRule.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR CDD; cd16337; MukF_C; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 1.10.225.40; -; 1.
DR Gene3D; 1.20.58.590; -; 1.
DR HAMAP; MF_01803; MukF; 1.
DR InterPro; IPR005582; Chromosome_partition_MukF.
DR InterPro; IPR033441; MukF_C.
DR InterPro; IPR038198; MukF_C_sf.
DR InterPro; IPR033440; MukF_M.
DR InterPro; IPR036141; MukF_M_sp.
DR InterPro; IPR033439; MukF_WHTH.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF03882; KicB; 1.
DR Pfam; PF17193; MukF_C; 1.
DR Pfam; PF17192; MukF_M; 1.
DR PIRSF; PIRSF018282; MukF; 1.
DR SUPFAM; SSF140570; SSF140570; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
PE 3: Inferred from homology;
KW Calcium; Cell cycle; Cell division; Chromosome partition; Cytoplasm;
KW DNA condensation; Reference proteome.
FT CHAIN 1..440
FT /note="Chromosome partition protein MukF"
FT /id="PRO_0000211611"
FT REGION 208..236
FT /note="Leucine-zipper"
SQ SEQUENCE 440 AA; 50579 MW; 55824FD545247EE8 CRC64;
MSEFSQTVPE LVAWARKNDF SISLPVDRLS FLLAVATLNG ERLDGEMSEG ELVDAFRHVS
DAFEQTSETI GVRANNAIND MVRQRLLNRF TSEQAEGNAI YRLTPLGIGI TDYYIRQREF
STLRLSMQLS IVAGELKRAA DAAEEGGDEF HWHRNVYAPL KYSVAEIFDS IDLTQRLMDE
QQQQVKDDIA QLLNKDWRAA ISSCELLLSE TSGTLRELQD TLEAAGDKLQ ANLLRIQDAT
MTHDDLHFVD RLVFDLQSKL DRIISWGQQS IDLWIGYDRH VHKFIRTAID MDKNRVFAQR
LRQSVQTYFD EPWALTYANA DRLLDMRDEE MALRDEEVTG ELPEDLEYEE FNEIREQLAA
IIEEQLAVYK TRQVPLDLGL VVREYLSQYP RARHFDVARI VIDQAVRLGV AQADFTGLPA
KWQPINDYGA KVQAHVIDKY
