MUP17_MOUSE
ID MUP17_MOUSE Reviewed; 180 AA.
AC B5X0G2;
DT 25-JAN-2012, integrated into UniProtKB/Swiss-Prot.
DT 25-JAN-2012, sequence version 2.
DT 03-AUG-2022, entry version 87.
DE RecName: Full=Major urinary protein 17;
DE Short=MUP 17;
DE Flags: Precursor;
GN Name=Mup17; Synonyms=Mup15;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 3-180.
RX PubMed=18815613; DOI=10.1371/journal.pone.0003280;
RA Logan D.W., Marton T.F., Stowers L.;
RT "Species specificity in major urinary proteins by parallel evolution.";
RL PLoS ONE 3:E3280-E3280(2008).
RN [3]
RP TISSUE SPECIFICITY.
RX PubMed=18507838; DOI=10.1186/gb-2008-9-5-r91;
RA Mudge J.M., Armstrong S.D., McLaren K., Beynon R.J., Hurst J.L.,
RA Nicholson C., Robertson D.H., Wilming L.G., Harrow J.L.;
RT "Dynamic instability of the major urinary protein gene family revealed by
RT genomic and phenotypic comparisons between C57 and 129 strain mice.";
RL Genome Biol. 9:R91.1-R91.16(2008).
CC -!- FUNCTION: Major urinary proteins (Mups) bind pheromones, thus stabilize
CC them and allow slow release into the air from urine marks. May protect
CC pheromones from oxidation. May also act as pheromones themselves. In
CC this context, they play a role in the regulation of social behaviors,
CC such as aggression, mating, pup-suckling, territory establishment and
CC dominance (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Because of their involvement in the coordination of
CC social behavior, Mup proteins are thought to exhibit variable
CC expression depending upon gender, age and status of the studied
CC individuals. Expression may also be strain-specific: in strains
CC C57BL/6J and 129S7, transcriptional support is lacking for Mup17.
CC {ECO:0000269|PubMed:18507838}.
CC -!- SIMILARITY: Belongs to the calycin superfamily. Lipocalin family.
CC {ECO:0000305}.
CC -!- CAUTION: Mups are encoded by multiple paralogous genes which are very
CC similar to each other, making accurate identification difficult. The
CC recommended nomenclature used in this entry is based on that provided
CC by the MGI database. {ECO:0000305}.
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DR EMBL; BX001066; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BK006665; DAA06311.1; -; Genomic_DNA.
DR CCDS; CCDS51198.1; -.
DR RefSeq; NP_001186935.1; NM_001200006.1.
DR AlphaFoldDB; B5X0G2; -.
DR BMRB; B5X0G2; -.
DR SMR; B5X0G2; -.
DR STRING; 10090.ENSMUSP00000103108; -.
DR Allergome; 478; Mus m 1.
DR iPTMnet; B5X0G2; -.
DR PhosphoSitePlus; B5X0G2; -.
DR SwissPalm; B5X0G2; -.
DR jPOST; B5X0G2; -.
DR MaxQB; B5X0G2; -.
DR PaxDb; B5X0G2; -.
DR PeptideAtlas; B5X0G2; -.
DR PRIDE; B5X0G2; -.
DR Ensembl; ENSMUST00000107484; ENSMUSP00000103108; ENSMUSG00000096688.
DR GeneID; 100039206; -.
DR KEGG; mmu:100039206; -.
DR UCSC; uc012dfm.2; mouse.
DR CTD; 100039206; -.
DR MGI; MGI:3705217; Mup17.
DR VEuPathDB; HostDB:ENSMUSG00000096688; -.
DR eggNOG; ENOG502S6GK; Eukaryota.
DR GeneTree; ENSGT01050000244868; -.
DR HOGENOM; CLU_094061_4_0_1; -.
DR InParanoid; B5X0G2; -.
DR OrthoDB; 1475169at2759; -.
DR PhylomeDB; B5X0G2; -.
DR TreeFam; TF338197; -.
DR BioGRID-ORCS; 100039206; 1 hit in 18 CRISPR screens.
DR ChiTaRS; Mup17; mouse.
DR PRO; PR:B5X0G2; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; B5X0G2; protein.
DR Bgee; ENSMUSG00000096688; Expressed in liver and 23 other tissues.
DR GO; GO:0005615; C:extracellular space; ISO:MGI.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0005550; F:pheromone binding; IEA:UniProtKB-KW.
DR GO; GO:0036094; F:small molecule binding; IEA:InterPro.
DR Gene3D; 2.40.128.20; -; 1.
DR InterPro; IPR012674; Calycin.
DR InterPro; IPR002345; Lipocalin.
DR InterPro; IPR022272; Lipocalin_CS.
DR InterPro; IPR000566; Lipocln_cytosolic_FA-bd_dom.
DR InterPro; IPR002971; Maj_urinary.
DR PANTHER; PTHR11430; PTHR11430; 1.
DR Pfam; PF00061; Lipocalin; 1.
DR PRINTS; PR01221; MAJORURINARY.
DR SUPFAM; SSF50814; SSF50814; 1.
DR PROSITE; PS00213; LIPOCALIN; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Pheromone-binding; Reference proteome; Secreted; Signal;
KW Transport.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT CHAIN 19..180
FT /note="Major urinary protein 17"
FT /id="PRO_0000415145"
FT DISULFID 82..175
FT /evidence="ECO:0000250"
SQ SEQUENCE 180 AA; 20638 MW; 5B939D0CE561F9B1 CRC64;
MKMLLLLCLG LTLVCVHAEE ASSTGRNFNV EKINGEWHTI ILASDKREKI EEHGNFRLFL
EQIHVLENSL VLKVHTVRDE ECSELSMVAD KTEKAGEYSV TYDGFNTFTI PKTDYDNFLM
AHLINEKDGE TFQLMGLYGR EPDLSSDIKE RFAQLCEEHG ILRENIIDLS NANRCLQARE
