ID   MUP18_MOUSE             Reviewed;         181 AA.
AC   A2BIM8;
DT   20-JAN-2016, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=Major urinary protein 18 {ECO:0000312|MGI:MGI:3705220};
DE   Flags: Precursor;
GN   Name=Mup18 {ECO:0000312|MGI:MGI:3705220};
GN   Synonyms=Mup16 {ECO:0000303|PubMed:18815613};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1] {ECO:0000312|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000312|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2] {ECO:0000312|EMBL:DAA06312.1}
RP   IDENTIFICATION.
RX   PubMed=18815613; DOI=10.1371/journal.pone.0003280;
RA   Logan D.W., Marton T.F., Stowers L.;
RT   "Species specificity in major urinary proteins by parallel evolution.";
RL   PLoS ONE 3:E3280-E3280(2008).
CC   -!- FUNCTION: Major urinary proteins (Mups) bind pheromones, and thus
CC       stabilize them to allow slow release into the air from urine marks. May
CC       protect pheromones from oxidation. May also act as pheromones
CC       themselves. In this context, they play a role in the regulation of
CC       social behaviors, such as aggression, mating, pup-suckling, territory
CC       establishment and dominance. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q5FW60}.
CC   -!- SIMILARITY: Belongs to the calycin superfamily. Lipocalin family.
CC       {ECO:0000255|RuleBase:RU003695}.
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DR   EMBL; BX470151; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BK006667; DAA06312.1; -; Genomic_DNA.
DR   CCDS; CCDS51199.1; -.
DR   RefSeq; NP_001157998.1; NM_001164526.1.
DR   RefSeq; NP_001186262.1; NM_001199333.1.
DR   AlphaFoldDB; A2BIM8; -.
DR   SMR; A2BIM8; -.
DR   Allergome; 478; Mus m 1.
DR   iPTMnet; A2BIM8; -.
DR   PhosphoSitePlus; A2BIM8; -.
DR   SwissPalm; A2BIM8; -.
DR   jPOST; A2BIM8; -.
DR   PRIDE; A2BIM8; -.
DR   DNASU; 100048884; -.
DR   Ensembl; ENSMUST00000098040; ENSMUSP00000095648; ENSMUSG00000078674.
DR   Ensembl; ENSMUST00000098046; ENSMUSP00000095654; ENSMUSG00000073834.
DR   GeneID; 100039028; -.
DR   GeneID; 100048884; -.
DR   KEGG; mmu:100039028; -.
DR   KEGG; mmu:100048884; -.
DR   UCSC; uc008taw.3; mouse.
DR   CTD; 100039028; -.
DR   CTD; 100048884; -.
DR   MGI; MGI:3705220; Mup18.
DR   VEuPathDB; HostDB:ENSMUSG00000073834; -.
DR   VEuPathDB; HostDB:ENSMUSG00000078674; -.
DR   HOGENOM; CLU_094061_4_0_1; -.
DR   OMA; HASGECK; -.
DR   OrthoDB; 1475169at2759; -.
DR   PhylomeDB; A2BIM8; -.
DR   TreeFam; TF338197; -.
DR   BioGRID-ORCS; 100039028; 2 hits in 10 CRISPR screens.
DR   BioGRID-ORCS; 100048884; 4 hits in 23 CRISPR screens.
DR   ChiTaRS; Mup18; mouse.
DR   PRO; PR:A2BIM8; -.
DR   Proteomes; UP000000589; Chromosome 4.
DR   RNAct; A2BIM8; protein.
DR   Bgee; ENSMUSG00000073834; Expressed in liver and 35 other tissues.
DR   ExpressionAtlas; A2BIM8; baseline and differential.
DR   GO; GO:0005615; C:extracellular space; ISO:MGI.
DR   GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR   GO; GO:0005550; F:pheromone binding; IEA:UniProtKB-KW.
DR   GO; GO:0036094; F:small molecule binding; IEA:InterPro.
DR   GO; GO:0007610; P:behavior; IEA:UniProtKB-KW.
DR   Gene3D; 2.40.128.20; -; 1.
DR   InterPro; IPR012674; Calycin.
DR   InterPro; IPR002345; Lipocalin.
DR   InterPro; IPR022272; Lipocalin_CS.
DR   InterPro; IPR000566; Lipocln_cytosolic_FA-bd_dom.
DR   InterPro; IPR002971; Maj_urinary.
DR   PANTHER; PTHR11430; PTHR11430; 1.
DR   Pfam; PF00061; Lipocalin; 1.
DR   PRINTS; PR01221; MAJORURINARY.
DR   SUPFAM; SSF50814; SSF50814; 1.
DR   PROSITE; PS00213; LIPOCALIN; 1.
PE   3: Inferred from homology;
KW   Behavior; Disulfide bond; Pheromone-binding; Reference proteome; Secreted;
KW   Signal; Transport.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..181
FT                   /note="Major urinary protein 18"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_5005334073"
FT   DISULFID        83..176
FT                   /evidence="ECO:0000250|UniProtKB:P11590"
SQ   SEQUENCE   181 AA;  20763 MW;  D81FEBBF70A7E310 CRC64;
     MKMLLLLLCL GLTLVCVHAE EASSTGRNFN VEKINGEWHT IILASDKREK IEDNGNFRLF
     LEQIHVLENS LVLKFHTVRD EECSELSMVA DKTEKAGEYS VTYDGFNTFT IPKTDYDNFL
     MAHLINEKDG ETFQLMGLYG REPDLSSDIK ERFAQLCEEH GILRENIIDL SNANRCLQAR
     E