ID   MUP_RATRT               Reviewed;          46 AA.
AC   P84855;
DT   30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   29-MAY-2007, sequence version 2.
DT   25-MAY-2022, entry version 37.
DE   RecName: Full=Major urinary protein;
DE            Short=MUP;
DE   AltName: Full=Alpha(2)-euglobulin;
DE   AltName: Full=Alpha-2u-globulin;
DE   Flags: Fragments;
OS   Rattus rattus (Black rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10117;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, FUNCTION, TISSUE SPECIFICITY, AND INDUCTION.
RC   TISSUE=Preputial gland {ECO:0000269|Ref.1}, and Urine {ECO:0000269|Ref.1};
RA   Rajkumar R.;
RT   "Identification, purification and characterization of alpha 2u globulin (a
RT   pheromone binding protein) in the male house rat, Rattus rattus L.";
RL   Thesis (2007), Bharathidasan University, India.
RN   [2] {ECO:0000305}
RP   PROTEIN SEQUENCE.
RC   TISSUE=Preputial gland, and Urine;
RA   Rajkumar R., Archunan G.;
RL   Submitted (MAY-2007) to UniProtKB.
CC   -!- FUNCTION: Binds pheromones that are released from drying urine of
CC       males. These pheromones affect the sexual behavior of females (By
CC       similarity). Acts as a shuttle for pheromonal communication between
CC       individuals of the same species. {ECO:0000250|UniProtKB:P02761,
CC       ECO:0000269|Ref.1}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Found in many tissues including liver, urine,
CC       preputial gland, clitoral gland, submandibular gland and salivary
CC       gland. {ECO:0000269|Ref.1}.
CC   -!- INDUCTION: Repressed by estrogen. {ECO:0000269|Ref.1}.
CC   -!- SIMILARITY: Belongs to the calycin superfamily. Lipocalin family.
CC       {ECO:0000305}.
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DR   AlphaFoldDB; P84855; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005550; F:pheromone binding; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Glycoprotein; Pheromone-binding; Secreted;
KW   Transport.
FT   CHAIN           <1..>46
FT                   /note="Major urinary protein"
FT                   /id="PRO_0000238927"
FT   CARBOHYD        15
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   NON_CONS        9..10
FT                   /evidence="ECO:0000303|Ref.1"
FT   NON_CONS        19..20
FT                   /evidence="ECO:0000303|Ref.1"
FT   NON_CONS        30..31
FT                   /evidence="ECO:0000303|Ref.1"
FT   NON_TER         1
FT                   /evidence="ECO:0000303|Ref.1"
FT   NON_TER         46
FT                   /evidence="ECO:0000303|Ref.1"
SQ   SEQUENCE   46 AA;  5287 MW;  E46A5C8CA6C56FC7 CRC64;
     LCVAHGITRE KIEENGSMRE NIIDVTKTNR VFMQHIDVLE NSLGFK