MURC_CAUVN
ID MURC_CAUVN Reviewed; 473 AA.
AC B8H086;
DT 28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 03-MAR-2009, sequence version 1.
DT 03-AUG-2022, entry version 81.
DE RecName: Full=UDP-N-acetylmuramate--L-alanine ligase {ECO:0000255|HAMAP-Rule:MF_00046};
DE EC=6.3.2.8 {ECO:0000255|HAMAP-Rule:MF_00046};
DE AltName: Full=UDP-N-acetylmuramoyl-L-alanine synthetase {ECO:0000255|HAMAP-Rule:MF_00046};
GN Name=murC {ECO:0000255|HAMAP-Rule:MF_00046}; OrderedLocusNames=CCNA_02629;
OS Caulobacter vibrioides (strain NA1000 / CB15N) (Caulobacter crescentus).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Caulobacterales;
OC Caulobacteraceae; Caulobacter.
OX NCBI_TaxID=565050;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NA1000 / CB15N;
RX PubMed=20472802; DOI=10.1128/jb.00255-10;
RA Marks M.E., Castro-Rojas C.M., Teiling C., Du L., Kapatral V.,
RA Walunas T.L., Crosson S.;
RT "The genetic basis of laboratory adaptation in Caulobacter crescentus.";
RL J. Bacteriol. 192:3678-3688(2010).
CC -!- FUNCTION: Cell wall formation. {ECO:0000255|HAMAP-Rule:MF_00046}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-alanine + UDP-N-acetyl-alpha-D-muramate = ADP + H(+) +
CC phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine;
CC Xref=Rhea:RHEA:23372, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:57972, ChEBI:CHEBI:70757,
CC ChEBI:CHEBI:83898, ChEBI:CHEBI:456216; EC=6.3.2.8;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00046};
CC -!- PATHWAY: Cell wall biogenesis; peptidoglycan biosynthesis.
CC {ECO:0000255|HAMAP-Rule:MF_00046}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00046}.
CC -!- SIMILARITY: Belongs to the MurCDEF family. {ECO:0000255|HAMAP-
CC Rule:MF_00046}.
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DR EMBL; CP001340; ACL96094.1; -; Genomic_DNA.
DR RefSeq; WP_010920403.1; NC_011916.1.
DR RefSeq; YP_002518002.1; NC_011916.1.
DR AlphaFoldDB; B8H086; -.
DR SMR; B8H086; -.
DR PRIDE; B8H086; -.
DR EnsemblBacteria; ACL96094; ACL96094; CCNA_02629.
DR GeneID; 7332731; -.
DR KEGG; ccs:CCNA_02629; -.
DR PATRIC; fig|565050.3.peg.2578; -.
DR HOGENOM; CLU_028104_2_2_5; -.
DR OMA; DITYQLR; -.
DR OrthoDB; 307881at2; -.
DR PhylomeDB; B8H086; -.
DR UniPathway; UPA00219; -.
DR Proteomes; UP000001364; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008763; F:UDP-N-acetylmuramate-L-alanine ligase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW.
DR GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:UniProtKB-UniRule.
DR GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.
DR Gene3D; 3.40.1190.10; -; 1.
DR Gene3D; 3.90.190.20; -; 1.
DR HAMAP; MF_00046; MurC; 1.
DR InterPro; IPR036565; Mur-like_cat_sf.
DR InterPro; IPR004101; Mur_ligase_C.
DR InterPro; IPR036615; Mur_ligase_C_dom_sf.
DR InterPro; IPR013221; Mur_ligase_cen.
DR InterPro; IPR000713; Mur_ligase_N.
DR InterPro; IPR005758; UDP-N-AcMur_Ala_ligase_MurC.
DR Pfam; PF01225; Mur_ligase; 1.
DR Pfam; PF02875; Mur_ligase_C; 1.
DR Pfam; PF08245; Mur_ligase_M; 1.
DR SUPFAM; SSF53244; SSF53244; 1.
DR SUPFAM; SSF53623; SSF53623; 1.
DR TIGRFAMs; TIGR01082; murC; 1.
PE 3: Inferred from homology;
KW ATP-binding; Cell cycle; Cell division; Cell shape;
KW Cell wall biogenesis/degradation; Cytoplasm; Ligase; Nucleotide-binding;
KW Peptidoglycan synthesis; Reference proteome.
FT CHAIN 1..473
FT /note="UDP-N-acetylmuramate--L-alanine ligase"
FT /id="PRO_1000117399"
FT BINDING 119..125
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00046"
SQ SEQUENCE 473 AA; 50302 MW; 7D40219A5CA35555 CRC64;
MIQRRRPVPF ELGPVHFIGI GGIGMSGIAE IMIRIGYTVQ GSDAKASANT ERLEKLGARI
FIGHDAAHVE GASAIVYSTA VKADNPEMVA GRDKRLPLVR RAEMLAELMR LQFSVAVGGT
HGKTTTTSMV AALLDAGGLD PTVVNGGIIN AYGTNAKVGE GDWIVVEADE SDGSFLKLKS
TVAIVTNIDA EHLDHWGDFD AVKKGFQDFI QNIPFYGFAA VCTDHPEVQA LTSRIENRRL
VTYGTNPQAE VRVSNIEMGP EGATFDIIVS PRAGEAVRYD GLKMPMAGHH NVLNATAAVA
VARELGVDAE AIAKGLAGFG GVKRRFTTTG VANGIRVVDD YGHHPVEIAA VLKAARAVTP
NGKVIAVVQP HRFTRLRDLM TEFSSCFNDA DTVIVADVYT AGEQPIPGVD RDALVAGLKK
FGHRRALPLE NPTALPRLIA AEATSGDLVV LLGAGDITTW SYALPGQLEA LTK