ID   A103_SCHMA              Reviewed;         263 AA.
AC   P13492;
DT   01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1990, sequence version 1.
DT   25-MAY-2022, entry version 58.
DE   RecName: Full=Antigen 10-3;
DE   Flags: Precursor;
OS   Schistosoma mansoni (Blood fluke).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC   Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX   NCBI_TaxID=6183;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
RC   STRAIN=Puerto Rican;
RX   PubMed=3211127; DOI=10.1128/mcb.8.11.4745-4755.1988;
RA   Davis R.E., Davis A.H., Carroll S.M., Rajkovic A., Rottman F.M.;
RT   "Tandemly repeated exons encode 81-base repeats in multiple,
RT   developmentally regulated Schistosoma mansoni transcripts.";
RL   Mol. Cell. Biol. 8:4745-4755(1988).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC         Comment=Additional isoforms seem to exist.;
CC       Name=1;
CC         IsoId=P13492-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=P13492-2; Sequence=VSP_004087;
CC   -!- DEVELOPMENTAL STAGE: Different-sized isoforms are expressed in the
CC       adult and cercarial stages.
CC   -!- MISCELLANEOUS: This antigen is recognized by sera from infected human.
CC   -!- MISCELLANEOUS: Isoforms are highly similar and contain variable numbers
CC       of identical direct tandem repeats of 81 bases.
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DR   EMBL; M22346; AAA29855.1; -; mRNA.
DR   PIR; A31561; A31561.
DR   AlphaFoldDB; P13492; -.
DR   Proteomes; UP000008854; Unassembled WGS sequence.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Reference proteome; Repeat; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..263
FT                   /note="Antigen 10-3"
FT                   /id="PRO_0000020578"
FT   REPEAT          81..107
FT                   /note="1"
FT   REPEAT          108..134
FT                   /note="2"
FT   REPEAT          135..161
FT                   /note="3"
FT   REPEAT          162..188
FT                   /note="4"
FT   REPEAT          189..206
FT                   /note="5"
FT   REGION          70..207
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          81..189
FT                   /note="5 X 27 AA tandem repeats"
FT   COMPBIAS        80..98
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        106..125
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        133..152
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        160..179
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        187..205
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         61..70
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:3211127"
FT                   /id="VSP_004087"
SQ   SEQUENCE   263 AA;  29641 MW;  A33A70AA1E23E74E CRC64;
     MNIYLIGILC IVGLIISQGS TANGSPLDDR FNDVNTINKK QFTEEEFSRL INSMLKKYIE
     DKNVDIRIIG NKKDKQPTQK TTPKPTTPKQ INDGTSDKTS DTHTIKRTTP KPTTPKQIND
     GTSDKTSDTH TIKRTTPKPT TPKQINDGTS DKTSDTHTIK RTTPKPTTPK QINDGTSDKT
     SDTHTIKRTT PKPTTPKQIN DGTSDKPKSI ADIFLINKPK VPLWIVNPLY YMVEKFVQIM
     GYLLEDDDTL ELNLPKYYYD KSI