MURE_MAIZE
ID MURE_MAIZE Reviewed; 760 AA.
AC K7WCC7; B4FW59;
DT 25-OCT-2017, integrated into UniProtKB/Swiss-Prot.
DT 06-FEB-2013, sequence version 1.
DT 03-AUG-2022, entry version 61.
DE RecName: Full=UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE homolog, chloroplastic {ECO:0000305};
DE Short=ZmMURE {ECO:0000303|PubMed:24246379};
DE Flags: Precursor;
GN Name=MURE {ECO:0000303|PubMed:24246379};
GN ORFNames=ZEAMMB73_Zm00001d047128 {ECO:0000312|EMBL:AQL05665.1};
OS Zea mays (Maize).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC Panicoideae; Andropogonodae; Andropogoneae; Tripsacinae; Zea.
OX NCBI_TaxID=4577;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. B73;
RX PubMed=19965430; DOI=10.1126/science.1178534;
RA Schnable P.S., Ware D., Fulton R.S., Stein J.C., Wei F., Pasternak S.,
RA Liang C., Zhang J., Fulton L., Graves T.A., Minx P., Reily A.D.,
RA Courtney L., Kruchowski S.S., Tomlinson C., Strong C., Delehaunty K.,
RA Fronick C., Courtney B., Rock S.M., Belter E., Du F., Kim K., Abbott R.M.,
RA Cotton M., Levy A., Marchetto P., Ochoa K., Jackson S.M., Gillam B.,
RA Chen W., Yan L., Higginbotham J., Cardenas M., Waligorski J., Applebaum E.,
RA Phelps L., Falcone J., Kanchi K., Thane T., Scimone A., Thane N., Henke J.,
RA Wang T., Ruppert J., Shah N., Rotter K., Hodges J., Ingenthron E.,
RA Cordes M., Kohlberg S., Sgro J., Delgado B., Mead K., Chinwalla A.,
RA Leonard S., Crouse K., Collura K., Kudrna D., Currie J., He R.,
RA Angelova A., Rajasekar S., Mueller T., Lomeli R., Scara G., Ko A.,
RA Delaney K., Wissotski M., Lopez G., Campos D., Braidotti M., Ashley E.,
RA Golser W., Kim H., Lee S., Lin J., Dujmic Z., Kim W., Talag J., Zuccolo A.,
RA Fan C., Sebastian A., Kramer M., Spiegel L., Nascimento L., Zutavern T.,
RA Miller B., Ambroise C., Muller S., Spooner W., Narechania A., Ren L.,
RA Wei S., Kumari S., Faga B., Levy M.J., McMahan L., Van Buren P.,
RA Vaughn M.W., Ying K., Yeh C.-T., Emrich S.J., Jia Y., Kalyanaraman A.,
RA Hsia A.-P., Barbazuk W.B., Baucom R.S., Brutnell T.P., Carpita N.C.,
RA Chaparro C., Chia J.-M., Deragon J.-M., Estill J.C., Fu Y., Jeddeloh J.A.,
RA Han Y., Lee H., Li P., Lisch D.R., Liu S., Liu Z., Nagel D.H., McCann M.C.,
RA SanMiguel P., Myers A.M., Nettleton D., Nguyen J., Penning B.W.,
RA Ponnala L., Schneider K.L., Schwartz D.C., Sharma A., Soderlund C.,
RA Springer N.M., Sun Q., Wang H., Waterman M., Westerman R., Wolfgruber T.K.,
RA Yang L., Yu Y., Zhang L., Zhou S., Zhu Q., Bennetzen J.L., Dawe R.K.,
RA Jiang J., Jiang N., Presting G.G., Wessler S.R., Aluru S.,
RA Martienssen R.A., Clifton S.W., McCombie W.R., Wing R.A., Wilson R.K.;
RT "The B73 maize genome: complexity, diversity, and dynamics.";
RL Science 326:1112-1115(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 197-760.
RC STRAIN=cv. B73;
RX PubMed=19936069; DOI=10.1371/journal.pgen.1000740;
RA Soderlund C., Descour A., Kudrna D., Bomhoff M., Boyd L., Currie J.,
RA Angelova A., Collura K., Wissotski M., Ashley E., Morrow D., Fernandes J.,
RA Walbot V., Yu Y.;
RT "Sequencing, mapping, and analysis of 27,455 maize full-length cDNAs.";
RL PLoS Genet. 5:E1000740-E1000740(2009).
RN [3]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=24246379; DOI=10.1104/pp.113.228726;
RA Williams-Carrier R., Zoschke R., Belcher S., Pfalz J., Barkan A.;
RT "A major role for the plastid-encoded RNA polymerase complex in the
RT expression of plastid transfer RNAs.";
RL Plant Physiol. 164:239-248(2014).
RN [4]
RP FUNCTION, IDENTIFICATION BY MASS SPECTROMETRY, AND SUBUNIT.
RX PubMed=25599833; DOI=10.1111/nph.13248;
RA Pfalz J., Holtzegel U., Barkan A., Weisheit W., Mittag M., Pfannschmidt T.;
RT "ZmpTAC12 binds single-stranded nucleic acids and is essential for
RT accumulation of the plastid-encoded polymerase complex in maize.";
RL New Phytol. 206:1024-1037(2015).
CC -!- FUNCTION: Required for the activity of the plastid-encoded RNA
CC polymerase (PEP) and full expression of genes transcribed by PEP
CC (PubMed:24246379). Required for the proper build-up and formation of
CC the PEP-complex (PubMed:25599833). {ECO:0000269|PubMed:24246379,
CC ECO:0000269|PubMed:25599833}.
CC -!- SUBUNIT: Component of the plastid-encoded plastid RNA polymerase (PEP)
CC complex. {ECO:0000269|PubMed:25599833}.
CC -!- SUBCELLULAR LOCATION: Plastid, chloroplast {ECO:0000255}.
CC -!- DISRUPTION PHENOTYPE: Pale yellow-green leaf phenotype. Reduced levels
CC of plastid ribosomes and defects in plastid mRNA metabolism.
CC {ECO:0000269|PubMed:24246379}.
CC -!- SIMILARITY: Belongs to the MurCDEF family. MurE subfamily.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=ACF86352.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CM000785; AQL05665.1; -; Genomic_DNA.
DR EMBL; BT041347; ACF86352.1; ALT_INIT; mRNA.
DR RefSeq; NP_001141424.1; NM_001147952.1.
DR AlphaFoldDB; K7WCC7; -.
DR SMR; K7WCC7; -.
DR STRING; 4577.GRMZM2G009070_P01; -.
DR PaxDb; K7WCC7; -.
DR PRIDE; K7WCC7; -.
DR EnsemblPlants; Zm00001eb391750_T001; Zm00001eb391750_P001; Zm00001eb391750.
DR GeneID; 100273534; -.
DR Gramene; Zm00001eb391750_T001; Zm00001eb391750_P001; Zm00001eb391750.
DR KEGG; zma:100273534; -.
DR eggNOG; ENOG502QTHZ; Eukaryota.
DR HOGENOM; CLU_022291_4_0_1; -.
DR OMA; FIPGRML; -.
DR OrthoDB; 1363473at2759; -.
DR Proteomes; UP000007305; Chromosome 9.
DR ExpressionAtlas; K7WCC7; baseline and differential.
DR GO; GO:0009507; C:chloroplast; IEA:UniProtKB-SubCell.
DR GO; GO:0016881; F:acid-amino acid ligase activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR GO; GO:0051301; P:cell division; IEA:InterPro.
DR GO; GO:0010020; P:chloroplast fission; IEA:EnsemblPlants.
DR GO; GO:0008360; P:regulation of cell shape; IEA:InterPro.
DR GO; GO:0010468; P:regulation of gene expression; IMP:UniProtKB.
DR Gene3D; 3.40.1190.10; -; 1.
DR Gene3D; 3.90.190.20; -; 1.
DR InterPro; IPR036565; Mur-like_cat_sf.
DR InterPro; IPR004101; Mur_ligase_C.
DR InterPro; IPR036615; Mur_ligase_C_dom_sf.
DR InterPro; IPR013221; Mur_ligase_cen.
DR InterPro; IPR035911; MurE/MurF_N.
DR InterPro; IPR005761; UDP-N-AcMur-Glu-dNH2Pim_ligase.
DR Pfam; PF02875; Mur_ligase_C; 1.
DR Pfam; PF08245; Mur_ligase_M; 1.
DR SUPFAM; SSF53244; SSF53244; 1.
DR SUPFAM; SSF53623; SSF53623; 1.
DR SUPFAM; SSF63418; SSF63418; 1.
DR TIGRFAMs; TIGR01085; murE; 1.
PE 1: Evidence at protein level;
KW Chloroplast; Plastid; Reference proteome; Transcription;
KW Transcription regulation; Transit peptide.
FT TRANSIT 1..59
FT /note="Chloroplast"
FT /evidence="ECO:0000255"
FT CHAIN 60..760
FT /note="UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-
FT diaminopimelate ligase MurE homolog, chloroplastic"
FT /id="PRO_0000441844"
FT REGION 13..159
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 176..205
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 16..31
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 49..66
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 119..134
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 181..205
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 760 AA; 82561 MW; 0DA8EA3005687552 CRC64;
MATAPLAFRL PFPFSFPSAS RPPPSRILAP PTPRRLPLRL AAAAARRFRP PTADDEPPEA
AEDSSHGLTR YDQLARSVER ARIRQPEITP DNPLFSSPST AGGGGGGSYD PDDEFFDEID
RAIAEKREEF TRRGLIKPSP ASPPPSQSQP EDEDLTDELS PEEVIDLDEI RKLQGLSVVS
VADEEDEEVE GGEDEDDGLP LDEDGEGFDV AEELGLEGAR MRQPAFRMTL AELLDESKLV
PVAVTGDQDV ALAGVQRDAS LVAAGDLFVC VGEDGLAGLT EADKRGAVAV VADQDLNIEG
TLACRALVIV DDILTALRVL PACLYSRPSM NMAIIGVTGT DGVTTTTHLV KAMYEAMGVR
TGLVGVLGTY AFSSNKLDAR PDASSDPIAA QKLMATMLHN GTEAVVLEKG TDGMPPSGVD
SEIDYDIAVL TNVRHTDEEN GMTYEEYMSR MASLFSRMVD PERHRKVVNI DDPSAPFFAA
QGGHDVPVVT YSFENKKADV HTLKYQLSLF ETEVLVQTPH GILEISSGLL GRDNIYSILA
TVAVGIAVGA PLEDIVRGIE EVDAIPGRCE LIDEEQAFGV IVDHARTPEA LSRLLDGVRE
LGPRRIVTVV GCCGEKERGK RPVMTKIAAD KSDVVMLTSD NPANEDPLDI LDDMLAGVGW
TMEEYLKYGA NDYYPPLPNG HRLFLHDIRR VAVRAAVAMG EQGDVVVITG KGNDTYQIEG
DKNEFFDDRE ECREALQYVD QLHRAGIDTS EFPWRLPESH
