ID   A11_VARV                Reviewed;         319 AA.
AC   P0DOQ8; P33836;
DT   16-OCT-2019, integrated into UniProtKB/Swiss-Prot.
DT   16-OCT-2019, sequence version 1.
DT   23-FEB-2022, entry version 11.
DE   RecName: Full=Protein A11;
GN   ORFNames=A11R;
OS   Variola virus.
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus.
OX   NCBI_TaxID=10255;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Bangladesh-1975;
RX   PubMed=8264798; DOI=10.1038/366748a0;
RA   Massung R.F., Esposito J.J., Liu L.I., Qi J., Utterback T.R., Knight J.C.,
RA   Aubin L., Yuran T.E., Parsons J.M., Loparev V.N., Selivanov N.A.,
RA   Cavallaro K.F., Kerlavage A.R., Mahy B.W.J., Venter J.C.;
RT   "Potential virulence determinants in terminal regions of variola smallpox
RT   virus genome.";
RL   Nature 366:748-751(1993).
CC   -!- FUNCTION: Required for viral crescent formation early during virus
CC       morphogenesis. {ECO:0000250}.
CC   -!- SUBUNIT: Homomultimer. Interacts with A32. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000250}. Note=Localizes to
CC       the cytoplasmic viral factory. Not incorporated into virus particles.
CC       Does not seem to be a transmembrane protein (By similarity).
CC       {ECO:0000250}.
CC   -!- INDUCTION: Expressed in the late phase of the viral replicative cycle.
CC   -!- PTM: Phosphorylated by a F10-independent mechanism. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the poxviridae A11 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; L22579; AAA60863.1; -; Genomic_DNA.
DR   PIR; T28553; T28553.
DR   RefSeq; NP_042159.1; NC_001611.1.
DR   GeneID; 1486486; -.
DR   KEGG; vg:1486486; -.
DR   Proteomes; UP000119805; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   InterPro; IPR007755; Poxvirus_A11.
DR   Pfam; PF05061; Pox_A11; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Host cytoplasm; Late protein; Phosphoprotein.
FT   CHAIN           1..319
FT                   /note="Protein A11"
FT                   /id="PRO_0000448151"
FT   COILED          146..173
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   319 AA;  36234 MW;  E36F5BC0498C00D1 CRC64;
     MTTVPVTDIQ NDLITEFSED NYPSNKNYEI TLRQMSILTH VNNVVDREHN AAVVSSPEEI
     SSQLNEDLFP DDDSPATIIE RVQQPHTTII DDTPPPTFRR ELLISEQRQQ REKRFNITVS
     KNAEAIMESR SMITSMPTQT PSLGVVYDKD KRIQMLEDEV VNLRNQQSNT KSSNNLDNFT
     RILFGKTPYK STEVNKRIAI VNYANLNGSP LSVEDLDVCS EDEIDRIYKT IKQYHESRKR
     KIIVTNVIII VINIIEQALL KLGFDEIKGL STDITSEIID VEIGDDCDAV ASKLGIGNSP
     VLNIVLFILK IFVKRIKII