MURJ_CHLPN
ID MURJ_CHLPN Reviewed; 547 AA.
AC Q9Z7H5; Q9JQF1;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 25-MAY-2022, entry version 119.
DE RecName: Full=Probable lipid II flippase MurJ {ECO:0000250|UniProtKB:P0AF16};
GN Name=murJ; Synonyms=mviN; OrderedLocusNames=CPn_0730, CP_0016, CpB0758;
OS Chlamydia pneumoniae (Chlamydophila pneumoniae).
OC Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC Chlamydia/Chlamydophila group; Chlamydia.
OX NCBI_TaxID=83558;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CWL029;
RX PubMed=10192388; DOI=10.1038/7716;
RA Kalman S., Mitchell W.P., Marathe R., Lammel C.J., Fan J., Hyman R.W.,
RA Olinger L., Grimwood J., Davis R.W., Stephens R.S.;
RT "Comparative genomes of Chlamydia pneumoniae and C. trachomatis.";
RL Nat. Genet. 21:385-389(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AR39;
RX PubMed=10684935; DOI=10.1093/nar/28.6.1397;
RA Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F., White O.,
RA Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J., Bass S.,
RA Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C., Dodson R.J.,
RA Gwinn M.L., Nelson W.C., DeBoy R.T., Kolonay J.F., McClarty G.,
RA Salzberg S.L., Eisen J.A., Fraser C.M.;
RT "Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae
RT AR39.";
RL Nucleic Acids Res. 28:1397-1406(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=J138;
RX PubMed=10871362; DOI=10.1093/nar/28.12.2311;
RA Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K.,
RA Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.;
RT "Comparison of whole genome sequences of Chlamydia pneumoniae J138 from
RT Japan and CWL029 from USA.";
RL Nucleic Acids Res. 28:2311-2314(2000).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TW-183;
RA Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P.,
RA Schneider S., Pohl T., Essig A., Marre R., Melchers K.;
RT "The genome sequence of Chlamydia pneumoniae TW183 and comparison with
RT other Chlamydia strains based on whole genome sequence analysis.";
RL Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in peptidoglycan biosynthesis. Transports lipid-
CC linked peptidoglycan precursors from the inner to the outer leaflet of
CC the cytoplasmic membrane. {ECO:0000250|UniProtKB:P0AF16}.
CC -!- PATHWAY: Cell wall biogenesis; peptidoglycan biosynthesis.
CC {ECO:0000250|UniProtKB:P0AF16}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000250|UniProtKB:P0AF16}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the MurJ/MviN family. {ECO:0000305}.
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DR EMBL; AE001363; AAD18869.1; -; Genomic_DNA.
DR EMBL; AE002161; AAF37912.1; -; Genomic_DNA.
DR EMBL; BA000008; BAA98937.1; -; Genomic_DNA.
DR EMBL; AE009440; AAP98687.1; -; Genomic_DNA.
DR PIR; F72042; F72042.
DR PIR; G86581; G86581.
DR RefSeq; NP_224926.1; NC_000922.1.
DR RefSeq; WP_010883368.1; NZ_LN847257.1.
DR AlphaFoldDB; Q9Z7H5; -.
DR SMR; Q9Z7H5; -.
DR STRING; 115711.CP_0016; -.
DR EnsemblBacteria; AAD18869; AAD18869; CPn_0730.
DR EnsemblBacteria; AAF37912; AAF37912; CP_0016.
DR GeneID; 45050786; -.
DR KEGG; cpa:CP_0016; -.
DR KEGG; cpj:mviN; -.
DR KEGG; cpn:CPn_0730; -.
DR KEGG; cpt:CpB0758; -.
DR PATRIC; fig|115713.3.peg.805; -.
DR eggNOG; COG0728; Bacteria.
DR HOGENOM; CLU_497572_0_0_0; -.
DR OrthoDB; 749401at2; -.
DR UniPathway; UPA00219; -.
DR Proteomes; UP000000583; Chromosome.
DR Proteomes; UP000000801; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW.
DR GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.
DR CDD; cd13123; MATE_MurJ_like; 1.
DR InterPro; IPR004268; MurJ.
DR Pfam; PF03023; MurJ; 1.
DR PRINTS; PR01806; VIRFACTRMVIN.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Cell shape;
KW Cell wall biogenesis/degradation; Membrane; Peptidoglycan synthesis;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..547
FT /note="Probable lipid II flippase MurJ"
FT /id="PRO_0000182004"
FT TRANSMEM 32..52
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 96..116
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 122..142
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 156..176
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 186..206
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 227..247
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 270..290
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 308..328
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 355..375
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 380..400
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 408..428
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 457..477
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 495..515
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 547 AA; 61893 MW; A3BAC746A35BC48B CRC64;
MSRKDNEVSL ARSIFNILSG TFCSRITGIF REIAMATYFG ADPIVAAFWL GFRTVFFLRK
ILGGLILEQA FIPHFEFLRA QSLDRAAFFF RRFSRLIKGS TIIFTLLIEA VLWVVLQYVE
EGTYDMILLT MILLPCGIFL MMYNVNGALL HCENKFFGVG LAPVVVNIIW IFFVIAARHS
DPRERIIGLS VALVIGFFFE WLITVPGVWK FLLEAKSPPQ EHDSVRALLA PLSLGILTSS
IFQLNLLSDI CLARYVHEIG PLYLMYSLKI YQLPIHLFGF GVFTVLLPAI SRCVQREDHE
RGLKLMKFVL TLTMSVMIIM TAGLLLLALP GVRVLYEHGL FPQSAVYAIV RVLRGYGASI
IPMALAPLVS VLFYAQRQYA VPLFIGIGTA LANIVLSLVL GRWVLKDVSG ISYATSITAW
VQLYFLWYYS SKRLPMYSKL LWESIRRSIK VMGTTMLACM ITLGLNILTQ TTYVIFLNPL
TPLAWPLSSI TAQAIAFLSE SCIFLAFLFG FAKLLRVEDL INLASFEYWR GQRGLLQRQH
VMQDTQN
