ID   MURJ_CHLTR              Reviewed;         536 AA.
AC   Q46378; O84629;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2000, sequence version 2.
DT   25-MAY-2022, entry version 103.
DE   RecName: Full=Probable lipid II flippase MurJ {ECO:0000250|UniProtKB:P0AF16};
GN   Name=murJ; Synonyms=mviN; OrderedLocusNames=CT_624;
OS   Chlamydia trachomatis (strain D/UW-3/Cx).
OC   Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC   Chlamydia/Chlamydophila group; Chlamydia.
OX   NCBI_TaxID=272561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=D/UW-3/Cx;
RX   PubMed=9784136; DOI=10.1126/science.282.5389.754;
RA   Stephens R.S., Kalman S., Lammel C.J., Fan J., Marathe R., Aravind L.,
RA   Mitchell W.P., Olinger L., Tatusov R.L., Zhao Q., Koonin E.V., Davis R.W.;
RT   "Genome sequence of an obligate intracellular pathogen of humans: Chlamydia
RT   trachomatis.";
RL   Science 282:754-759(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Serovar B;
RA   Myers G.S.A., Sriprakash K.S.;
RT   "A membrane-associated gene cluster of Chlamydia trachomatis.";
RL   Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in peptidoglycan biosynthesis. Transports lipid-
CC       linked peptidoglycan precursors from the inner to the outer leaflet of
CC       the cytoplasmic membrane. {ECO:0000250|UniProtKB:P0AF16}.
CC   -!- PATHWAY: Cell wall biogenesis; peptidoglycan biosynthesis.
CC       {ECO:0000250|UniProtKB:P0AF16}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane
CC       {ECO:0000250|UniProtKB:P0AF16}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the MurJ/MviN family. {ECO:0000305}.
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DR   EMBL; AE001273; AAC68228.1; -; Genomic_DNA.
DR   EMBL; U50732; AAD08715.1; -; Genomic_DNA.
DR   PIR; A71491; A71491.
DR   RefSeq; NP_220141.1; NC_000117.1.
DR   RefSeq; WP_010725280.1; NC_000117.1.
DR   AlphaFoldDB; Q46378; -.
DR   SMR; Q46378; -.
DR   STRING; 813.O172_03410; -.
DR   EnsemblBacteria; AAC68228; AAC68228; CT_624.
DR   GeneID; 884403; -.
DR   KEGG; ctr:CT_624; -.
DR   PATRIC; fig|272561.5.peg.681; -.
DR   HOGENOM; CLU_497572_0_0_0; -.
DR   InParanoid; Q46378; -.
DR   OMA; IFFVAFK; -.
DR   UniPathway; UPA00219; -.
DR   Proteomes; UP000000431; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW.
DR   GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.
DR   InterPro; IPR004268; MurJ.
DR   Pfam; PF03023; MurJ; 1.
DR   PRINTS; PR01806; VIRFACTRMVIN.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Cell shape;
KW   Cell wall biogenesis/degradation; Membrane; Peptidoglycan synthesis;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..536
FT                   /note="Probable lipid II flippase MurJ"
FT                   /id="PRO_0000182005"
FT   TRANSMEM        12..34
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        54..74
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        95..115
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        122..142
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        155..175
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        185..205
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        226..246
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        269..289
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        311..331
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        354..374
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        382..402
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        406..426
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        454..474
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        493..513
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   VARIANT         8
FT                   /note="S -> C (in strain: Serovar B)"
FT   VARIANT         324..325
FT                   /note="LL -> FV (in strain: Serovar B)"
SQ   SEQUENCE   536 AA;  59881 MW;  1FE983172ED03B41 CRC64;
     MRKDDEGSLV RSLFNLLSGT FFSRLTGMLR EIVMATYFGA DPLVASFWLA FRTIFFLRKL
     LGGPILGLAF IPHFEFLRAQ NISRATFFFR SFSRFFCYSA ILFTLIIELG LCVWCSCVTG
     SLFDTLLLTI ILLPSGIFLM MYTVNSTLLH CEKKFFSVGL APSVVNVSWI GTVFLARNYD
     PRNRIFGLAV VLVIGFILEW AVTLPGVMKF LGQSKEVPQE RDSIRALIAP LSLGLLSMGI
     FQLNLLCDMW LARYINEVGP LYLMYSVRIQ QLPVHLFGLG VFTVLLPAIS RCVQDQEHQQ
     GYDLLRFSLK LTVAVMVVMT MGLLLFALPG VRVLYEHGVF PKTAVHAIVE VLRGYSGSII
     PMALAPLVSA LFYARRNYKV PMLVGIIAAV VNMVLNVIGC LVCKQVAVLA YATSLVSWGQ
     LAMLWYCAGK SLPTYKGLMW RTFKESGKTV ITTILAAVIT IGVNIVTHTT YVVFIEPLTV
     PTKPLVSFLD QCGVFFAESA LFLSVLFGLA KLLKTEDLMN LISFQYWKGH QSILRN