ID   A12_VAR67               Reviewed;         189 AA.
AC   P0DOK9; P33837;
DT   16-OCT-2019, integrated into UniProtKB/Swiss-Prot.
DT   16-OCT-2019, sequence version 1.
DT   23-FEB-2022, entry version 8.
DE   RecName: Full=25 kDa core protein A12L;
DE   Contains:
DE     RecName: Full=17 kDa core protein A12L;
DE              Short=17K;
GN   ORFNames=A12L;
OS   Variola virus (isolate Human/India/Ind3/1967) (VARV) (Smallpox virus).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus.
OX   NCBI_TaxID=587200;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=8384129; DOI=10.1016/0014-5793(93)80041-r;
RA   Shchelkunov S.N., Blinov V.M., Sandakhchiev L.S.;
RT   "Genes of variola and vaccinia viruses necessary to overcome the host
RT   protective mechanisms.";
RL   FEBS Lett. 319:80-83(1993).
CC   -!- FUNCTION: Component of the virion core that undergoes proteolytic
CC       processing during the immature virion (IV) to mature virion (MV)
CC       transition. Essential for the formation of a structurally normal core
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: [25 kDa core protein A12L]: Virion {ECO:0000250}.
CC       Note=Localizes to the virion core. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: [17 kDa core protein A12L]: Virion {ECO:0000250}.
CC       Note=Localizes to the virion core. {ECO:0000250}.
CC   -!- INDUCTION: Expressed in the late phase of the viral replicative cycle.
CC   -!- PTM: The 25-kDa precursor is cleaved to a mature protein of 17 kDa
CC       during virion maturation. Further proteolytic processing is supposed to
CC       occur since five more A12L-derived products have been observed (By
CC       similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the chordopoxvirinae A12 family. {ECO:0000305}.
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DR   EMBL; X69198; CAA49057.1; -; Genomic_DNA.
DR   PIR; D36849; D36849.
DR   RefSeq; NP_042160.1; NC_001611.1.
DR   SMR; P0DOK9; -.
DR   GeneID; 1486487; -.
DR   KEGG; vg:1486487; -.
DR   Proteomes; UP000002060; Genome.
DR   InterPro; IPR006744; Poxvirus_A12.
DR   Pfam; PF04651; Pox_A12; 1.
PE   2: Evidence at transcript level;
KW   Late protein; Reference proteome; Virion.
FT   CHAIN           1..189
FT                   /note="25 kDa core protein A12L"
FT                   /id="PRO_0000099238"
FT   CHAIN           1..56
FT                   /note="17 kDa core protein A12L"
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000413916"
FT   REGION          69..102
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          151..173
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   SITE            56..57
FT                   /note="Cleavage; by I7 protease"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   189 AA;  20192 MW;  A3092B675BEA0C63 CRC64;
     MADKKNLAVR SSYDDYIETV NKITPQLKNL LAQIGGDAAV KGGNNNLNSQ TDVTAGACDT
     KSKSSKCITC KSKSSSSSTS TSKSSKNTSG APRRRTTATT SFNAMDGQIV QAVTNAGKIV
     YGTVRDGQLE VRGMVGEINH DLLGIESVNA GKKKPSKKMP TNKKINMSSG MRRQEQINPN
     DCCLDMGMY