MURR_SHIF8
ID MURR_SHIF8 Reviewed; 266 AA.
AC Q0T281;
DT 03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT 05-SEP-2006, sequence version 1.
DT 25-MAY-2022, entry version 90.
DE RecName: Full=HTH-type transcriptional regulator MurR {ECO:0000255|HAMAP-Rule:MF_02108};
DE AltName: Full=MurPQ operon repressor {ECO:0000255|HAMAP-Rule:MF_02108};
GN Name=murR {ECO:0000255|HAMAP-Rule:MF_02108}; OrderedLocusNames=SFV_2480;
OS Shigella flexneri serotype 5b (strain 8401).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Shigella.
OX NCBI_TaxID=373384;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=8401;
RX PubMed=16822325; DOI=10.1186/1471-2164-7-173;
RA Nie H., Yang F., Zhang X., Yang J., Chen L., Wang J., Xiong Z., Peng J.,
RA Sun L., Dong J., Xue Y., Xu X., Chen S., Yao Z., Shen Y., Jin Q.;
RT "Complete genome sequence of Shigella flexneri 5b and comparison with
RT Shigella flexneri 2a.";
RL BMC Genomics 7:173-173(2006).
CC -!- FUNCTION: Represses the expression of the murPQ operon involved in the
CC uptake and degradation of N-acetylmuramic acid (MurNAc). Binds to two
CC adjacent inverted repeats within the operator region. MurNAc 6-
CC phosphate, the substrate of MurQ, is the specific inducer that weakens
CC binding of MurR to the operator. {ECO:0000255|HAMAP-Rule:MF_02108}.
CC -!- PATHWAY: Amino-sugar metabolism; N-acetylmuramate degradation
CC [regulation].
CC -!- SUBUNIT: Homotetramer. {ECO:0000255|HAMAP-Rule:MF_02108}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP000266; ABF04584.1; -; Genomic_DNA.
DR AlphaFoldDB; Q0T281; -.
DR SMR; Q0T281; -.
DR EnsemblBacteria; ABF04584; ABF04584; SFV_2480.
DR KEGG; sfv:SFV_2480; -.
DR HOGENOM; CLU_055769_0_2_6; -.
DR OMA; DHRIGSM; -.
DR UniPathway; UPA00342; -.
DR Proteomes; UP000000659; Chromosome.
DR GO; GO:0097367; F:carbohydrate derivative binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:1901135; P:carbohydrate derivative metabolic process; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0097173; P:N-acetylmuramic acid catabolic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR GO; GO:0043470; P:regulation of carbohydrate catabolic process; IEA:UniProtKB-UniRule.
DR CDD; cd05013; SIS_RpiR; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR HAMAP; MF_02108; HTH_type_MurR; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR000281; HTH_RpiR.
DR InterPro; IPR035472; RpiR-like_SIS.
DR InterPro; IPR001347; SIS_dom.
DR InterPro; IPR046348; SIS_dom_sf.
DR InterPro; IPR022821; Tscrpt_reg_HTH_MurR.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR Pfam; PF01418; HTH_6; 1.
DR Pfam; PF01380; SIS; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR SUPFAM; SSF53697; SSF53697; 1.
DR PROSITE; PS51071; HTH_RPIR; 1.
DR PROSITE; PS51464; SIS; 1.
PE 3: Inferred from homology;
KW Carbohydrate metabolism; DNA-binding; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..266
FT /note="HTH-type transcriptional regulator MurR"
FT /id="PRO_0000387775"
FT DOMAIN 1..77
FT /note="HTH rpiR-type"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_02108"
FT DOMAIN 128..266
FT /note="SIS"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_02108"
FT DNA_BIND 37..56
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_02108"
SQ SEQUENCE 266 AA; 29129 MW; 20858D13DF6298F6 CRC64;
MLYLTKIRNA ESEFTGNEQK IADFLRARVS ELKSVSSRQM AKQLGISQSS IVKFAQKLGA
QGFTELRMAL IGEYSASREK TNATALHLHS SITSDDSLEV IARKLNREKE LALEQTCALF
DYARLQKIIE VISKAPFIQI TGLGGSALVG RDLSFKLMKI GYRVACEADT HVQATVSQAL
KKGDVQIAIS YSGSKKEIVL CAEAARKQGA TVIAITSLAD SPLRRLAHFT LDTVSGETEW
RSSSMSTRTA QNSVTDLLFV GLVQHQ