MUS81_CANGA
ID MUS81_CANGA Reviewed; 628 AA.
AC Q6FYA6;
DT 21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 99.
DE RecName: Full=Crossover junction endonuclease MUS81;
DE EC=3.1.22.-;
GN Name=MUS81; OrderedLocusNames=CAGL0A03256g;
OS Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS Y-65) (Yeast) (Torulopsis glabrata).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC Nakaseomyces/Candida clade.
OX NCBI_TaxID=284593;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- FUNCTION: Interacts with EME1 to form a DNA structure-specific
CC endonuclease with substrate preference for branched DNA structures with
CC a 5'-end at the branch nick. Typical substrates include 3'-flap
CC structures, D-loops, replication forks and nicked Holliday junctions.
CC May be required in mitosis for the processing of stalled or collapsed
CC replication fork intermediates. May be required in meiosis for the
CC repair of meiosis-specific double strand breaks subsequent to single-
CC end invasion (SEI) (By similarity). {ECO:0000250}.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
CC -!- SUBUNIT: Interacts with EME1. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the XPF family. {ECO:0000305}.
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DR EMBL; CR380947; CAG57802.1; -; Genomic_DNA.
DR RefSeq; XP_444909.1; XM_444909.1.
DR AlphaFoldDB; Q6FYA6; -.
DR SMR; Q6FYA6; -.
DR STRING; 5478.XP_444909.1; -.
DR EnsemblFungi; CAG57802; CAG57802; CAGL0A03256g.
DR GeneID; 2886325; -.
DR KEGG; cgr:CAGL0A03256g; -.
DR CGD; CAL0126939; CAGL0A03256g.
DR VEuPathDB; FungiDB:CAGL0A03256g; -.
DR eggNOG; KOG2379; Eukaryota.
DR HOGENOM; CLU_014329_1_0_1; -.
DR InParanoid; Q6FYA6; -.
DR OMA; WIKEWLD; -.
DR Proteomes; UP000002428; Chromosome A.
DR GO; GO:0048476; C:Holliday junction resolvase complex; IEA:EnsemblFungi.
DR GO; GO:0043596; C:nuclear replication fork; IEA:EnsemblFungi.
DR GO; GO:0008821; F:crossover junction endodeoxyribonuclease activity; IEA:EnsemblFungi.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0004857; F:enzyme inhibitor activity; IEA:EnsemblFungi.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000737; P:DNA catabolic process, endonucleolytic; IEA:InterPro.
DR GO; GO:0006265; P:DNA topological change; IEA:EnsemblFungi.
DR GO; GO:0000727; P:double-strand break repair via break-induced replication; IEA:EnsemblFungi.
DR GO; GO:0051097; P:negative regulation of helicase activity; IEA:EnsemblFungi.
DR GO; GO:0000712; P:resolution of meiotic recombination intermediates; IEA:EnsemblFungi.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 1.10.150.110; -; 1.
DR Gene3D; 1.10.150.670; -; 1.
DR InterPro; IPR027421; DNA_pol_lamdba_lyase_dom_sf.
DR InterPro; IPR042530; EME1/EME2_C.
DR InterPro; IPR006166; ERCC4_domain.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR033309; Mus81.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR13451; PTHR13451; 1.
DR Pfam; PF02732; ERCC4; 1.
DR SMART; SM00891; ERCC4; 1.
DR SUPFAM; SSF47802; SSF47802; 1.
DR SUPFAM; SSF49785; SSF49785; 1.
DR SUPFAM; SSF52980; SSF52980; 1.
PE 3: Inferred from homology;
KW DNA damage; DNA recombination; DNA repair; Endonuclease; Hydrolase;
KW Magnesium; Manganese; Meiosis; Metal-binding; Nuclease; Nucleus;
KW Reference proteome.
FT CHAIN 1..628
FT /note="Crossover junction endonuclease MUS81"
FT /id="PRO_0000223703"
FT DOMAIN 348..445
FT /note="ERCC4"
FT REGION 298..318
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 299..318
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 628 AA; 72027 MW; D50C41E10BB70DC1 CRC64;
MLPDNLKDLY VQWLQELIDS LSEKQEQLIN TYSKAKKNLI DHDGVFYYPK DLLKVKGIGA
TIAKRLEARL VKHCEEIGVD VPRKQLPIDN GTQGSKSLKR VRTQLRIDGI NTNDTDINKP
VRKKRKYIPK KRSGAYAILL ALLELGAQNK GVIKPDIIEA AQKYTDHSMT PNYTTKEFYS
AWSSIAQLKK HELVLIEGRP QQYTLTEEGL QLADTLRLAD GIDIDGKSIA SSMDTNNAYY
SDEHTADFSA LKHDLSGLTC APIKDGTNSS GNYSILEKTF GSQDFNVRHH EIGMVQRSHT
FGNGDSNNSI EPLPRDTSEF TTQPSLIQRR RFESVSYELW QPGTYEIYPV IDHREVRSHS
DREFFFNAFK ARDMKSEIRQ LSLGDIIWVA KNKTTGQQCI LNTIIERKRL DDLAMSIRDN
RFMEQKNRLE KSGCKHKYYL IEETIGSSIG NMADALKTTL WIILVYYRFS MIRTVNAEDS
VDKLHALHTV ICESYKHKAL VVLYPTDLKS QDHYRGILSI FQNEFERSGN LECCHTFDTF
QDIMGKRELK TIKEITIHIL MLVRGVSLEK AVFIQRHFPT LNHLLNAYRK CNSQMEAKLM
MFQKFGNAPG AKKITKQLSE KLAETFAF