MUS81_DICDI
ID MUS81_DICDI Reviewed; 920 AA.
AC Q551H0; Q8T856;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 92.
DE RecName: Full=Probable crossover junction endonuclease mus81;
DE EC=3.1.22.-;
GN Name=mus81; ORFNames=DDB_G0276519;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Component of a DNA structure-specific endonuclease with
CC substrate preference for branched DNA structures with a 5'-end at the
CC branch nick. May be required in mitosis for the processing of stalled
CC or collapsed replication fork intermediates. May be required in meiosis
CC for the repair of meiosis-specific double strand breaks subsequent to
CC single-end invasion (SEI) (By similarity). {ECO:0000250}.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
CC -!- SUBUNIT: Interacts with eme1. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the XPF family. {ECO:0000305}.
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DR EMBL; AAFI02000015; EAL69213.1; -; Genomic_DNA.
DR RefSeq; XP_643164.1; XM_638072.1.
DR AlphaFoldDB; Q551H0; -.
DR SMR; Q551H0; -.
DR STRING; 44689.DDB0304698; -.
DR PaxDb; Q551H0; -.
DR EnsemblProtists; EAL69213; EAL69213; DDB_G0276519.
DR GeneID; 8620572; -.
DR KEGG; ddi:DDB_G0276519; -.
DR dictyBase; DDB_G0276519; mus81.
DR eggNOG; KOG2379; Eukaryota.
DR HOGENOM; CLU_316989_0_0_1; -.
DR InParanoid; Q551H0; -.
DR OMA; CIVDNRE; -.
DR PRO; PR:Q551H0; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0048476; C:Holliday junction resolvase complex; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0048257; F:3'-flap endonuclease activity; IBA:GO_Central.
DR GO; GO:0008821; F:crossover junction endodeoxyribonuclease activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000737; P:DNA catabolic process, endonucleolytic; IEA:InterPro.
DR GO; GO:0000727; P:double-strand break repair via break-induced replication; IBA:GO_Central.
DR GO; GO:0031573; P:mitotic intra-S DNA damage checkpoint signaling; IBA:GO_Central.
DR GO; GO:0000712; P:resolution of meiotic recombination intermediates; IBA:GO_Central.
DR Gene3D; 1.10.150.110; -; 1.
DR Gene3D; 1.10.150.670; -; 1.
DR InterPro; IPR027421; DNA_pol_lamdba_lyase_dom_sf.
DR InterPro; IPR042530; EME1/EME2_C.
DR InterPro; IPR006166; ERCC4_domain.
DR InterPro; IPR033309; Mus81.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR PANTHER; PTHR13451; PTHR13451; 1.
DR Pfam; PF02732; ERCC4; 1.
DR SMART; SM00891; ERCC4; 1.
DR SUPFAM; SSF47802; SSF47802; 1.
DR SUPFAM; SSF52980; SSF52980; 1.
PE 3: Inferred from homology;
KW DNA damage; DNA recombination; DNA repair; Endonuclease; Hydrolase;
KW Magnesium; Manganese; Metal-binding; Nuclease; Nucleus; Reference proteome.
FT CHAIN 1..920
FT /note="Probable crossover junction endonuclease mus81"
FT /id="PRO_0000367256"
FT DOMAIN 635..731
FT /note="ERCC4"
FT REGION 90..190
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 265..297
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 335..376
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 457..490
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 505..560
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 595..621
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 104..143
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 152..175
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 176..190
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 265..291
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 339..376
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 472..486
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 505..539
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 540..557
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 920 AA; 104294 MW; 968A2AFA57B9FFEE CRC64;
MSTNKNHNNN TNNNDNNICI NPHIVEFLNK QITNIKNRPG ADIKTTSIYK KAIRSLNLYP
LPVFSGKECE VLNGFGPSLT KKINDYLKTT SHPLYPKGPP TPLKSIYNRN NNNNDNNNNN
NNNNNNNNNN NNNNNNNNNN NSPKKKIRKS KNNNTTSTIS NTQSNLIGTE SPSKNQNKQL
ERELKSKKKK QQSAILEQIV EEEDINFEIP TNENYYDYGS GSCFDNNDDN DDGYISSGIN
TTPDDLNKSF NFDFGSFDNG IPNYNNNNDN GGDNENNINS DIDSNKIKTT TSINDNHKEK
YQKNNENYIH ENEDNGDDVI VLISPIKTYK YGDMLNKSPS KFKSPSKLRS HNTTNTFNNS
NFSNSDNDNN NNIRITTPLK NQNFNKFNDS IIFSPSISSP SPSKLSNYHK YLNNNNNNIK
NTPISTSKKR KCNFSSPLLF SPFKYGVTSP FSPSKMKLKS PFKKRFKNDK SPSSSISKNK
NSKSNDIVNN DFEDDDEVVN IQSESEINNN NNQFTSHNDN YNYSYNYNNN SNNINNNNNN
DDDDDFDLTE TEDEKDDYDK DDRTFSNLSV RLSFTEEDLA GVNIGESIIN NSKLPKVIPS
QIPPPTQSTQ STSTSTSTSK SKSKSTIKIK FKNIKCIIDN REVKSVTERD YICNKLNERG
INAQVKKLEL GDFVWVAIDE HDNEWLLNYI IERKRVDDLS SSIIDGRYKE QKFRLSKSGC
DNIIYLIEGI VSNTINSSSQ SQKKTWGTVN FSLSPDALAT ALVTTSICEG IIIKETKTID
NTIDYIVNIT EYFKEKLLKN NNSGGGGGDE IIKFLFANKN TQCTLENFNQ LNSKSKGLKL
IEFFATQLIQ IPGCSAEKAH SITQVYPTPM SLYLALKAIK DKESGESHFK DFTFGKNKRR
FGQDVSEVIY NLYTNKKYLN