MUS81_ORYSJ
ID MUS81_ORYSJ Reviewed; 660 AA.
AC Q8GT06; A0A0P0VCV7; B9EWF8;
DT 05-SEP-2012, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 25-MAY-2022, entry version 124.
DE RecName: Full=Crossover junction endonuclease MUS81;
DE EC=3.1.22.-;
DE AltName: Full=Protein MMS AND UV SENSITIVE 81;
DE Short=OsMUS81;
GN Name=MUS81; OrderedLocusNames=Os01g0948100, LOC_Os01g71960;
GN ORFNames=OsJ_04752, P0466H10.31;
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], ALTERNATIVE SPLICING, H-H-H MOTIF, INTERACTION
RP WITH RAD54, TISSUE SPECIFICITY, AND INDUCTION.
RC STRAIN=cv. Nipponbare;
RX PubMed=17327258; DOI=10.1093/pcp/pcm029;
RA Mimida N., Kitamoto H., Osakabe K., Nakashima M., Ito Y., Heyer W.D.,
RA Toki S., Ichikawa H.;
RT "Two alternatively spliced transcripts generated from OsMUS81, a rice
RT homolog of yeast MUS81, are up-regulated by DNA-damaging treatments.";
RL Plant Cell Physiol. 48:648-654(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=12447438; DOI=10.1038/nature01184;
RA Sasaki T., Matsumoto T., Yamamoto K., Sakata K., Baba T., Katayose Y.,
RA Wu J., Niimura Y., Cheng Z., Nagamura Y., Antonio B.A., Kanamori H.,
RA Hosokawa S., Masukawa M., Arikawa K., Chiden Y., Hayashi M., Okamoto M.,
RA Ando T., Aoki H., Arita K., Hamada M., Harada C., Hijishita S., Honda M.,
RA Ichikawa Y., Idonuma A., Iijima M., Ikeda M., Ikeno M., Ito S., Ito T.,
RA Ito Y., Ito Y., Iwabuchi A., Kamiya K., Karasawa W., Katagiri S.,
RA Kikuta A., Kobayashi N., Kono I., Machita K., Maehara T., Mizuno H.,
RA Mizubayashi T., Mukai Y., Nagasaki H., Nakashima M., Nakama Y.,
RA Nakamichi Y., Nakamura M., Namiki N., Negishi M., Ohta I., Ono N., Saji S.,
RA Sakai K., Shibata M., Shimokawa T., Shomura A., Song J., Takazaki Y.,
RA Terasawa K., Tsuji K., Waki K., Yamagata H., Yamane H., Yoshiki S.,
RA Yoshihara R., Yukawa K., Zhong H., Iwama H., Endo T., Ito H., Hahn J.H.,
RA Kim H.-I., Eun M.-Y., Yano M., Jiang J., Gojobori T.;
RT "The genome sequence and structure of rice chromosome 1.";
RL Nature 420:312-316(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=18089549; DOI=10.1093/nar/gkm978;
RG The rice annotation project (RAP);
RT "The rice annotation project database (RAP-DB): 2008 update.";
RL Nucleic Acids Res. 36:D1028-D1033(2008).
RN [5]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F.,
RA Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q.,
RA Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J.,
RA Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M.,
RA McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT "The genomes of Oryza sativa: a history of duplications.";
RL PLoS Biol. 3:266-281(2005).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=12869764; DOI=10.1126/science.1081288;
RG The rice full-length cDNA consortium;
RT "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT japonica rice.";
RL Science 301:376-379(2003).
CC -!- FUNCTION: Interacts with EME1 to form a DNA structure-specific
CC endonuclease with substrate preference for branched DNA structures with
CC a 5'-end at the branch nick. Typical substrates include 3'-flap
CC structures, D-loops, replication forks, nicked Holliday junctions and
CC also intact Holliday junctions with a reduced efficiency. May be
CC required in mitosis for the processing of stalled or collapsed
CC replication fork intermediates. Plays a role in DNA repair and in
CC genotoxic stress-induced homologous recombination (HR) in somatic
CC cells. Mediates a subset of meiotic recombination events that are
CC insensitive to crossover interference (By similarity). {ECO:0000250}.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000250};
CC -!- SUBUNIT: Forms a heterodimer with EME1 (By similarity). Interacts with
CC RAD54. {ECO:0000250, ECO:0000269|PubMed:17327258}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1; Synonyms=Alpha;
CC IsoId=Q8GT06-1; Sequence=Displayed;
CC Name=2; Synonyms=Beta;
CC IsoId=Q8GT06-2; Sequence=VSP_044049, VSP_044050;
CC -!- TISSUE SPECIFICITY: Low expression in shoots and roots from etiolated
CC seedlings, and panicles after meiosis; moderate expression in young
CC panicles under differentiation of floral organs before and during
CC meiosis; and high expression in mature leaves.
CC {ECO:0000269|PubMed:17327258}.
CC -!- INDUCTION: By DNA-damaging treatments such as high intensity light, UV-
CC C and gamma-radiation. {ECO:0000269|PubMed:17327258}.
CC -!- SIMILARITY: Belongs to the XPF family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=EEE55999.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AP003259; BAC15787.1; -; Genomic_DNA.
DR EMBL; AP008207; BAF07304.1; -; Genomic_DNA.
DR EMBL; AP014957; BAS76212.1; -; Genomic_DNA.
DR EMBL; CM000138; EEE55999.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AK111411; -; NOT_ANNOTATED_CDS; mRNA.
DR RefSeq; XP_015622535.1; XM_015767049.1. [Q8GT06-1]
DR AlphaFoldDB; Q8GT06; -.
DR SMR; Q8GT06; -.
DR IntAct; Q8GT06; 1.
DR STRING; 4530.OS01T0948100-01; -.
DR iPTMnet; Q8GT06; -.
DR PaxDb; Q8GT06; -.
DR PRIDE; Q8GT06; -.
DR EnsemblPlants; Os01t0948100-01; Os01t0948100-01; Os01g0948100. [Q8GT06-1]
DR GeneID; 4325837; -.
DR Gramene; Os01t0948100-01; Os01t0948100-01; Os01g0948100. [Q8GT06-1]
DR KEGG; osa:4325837; -.
DR eggNOG; KOG2379; Eukaryota.
DR HOGENOM; CLU_014329_2_0_1; -.
DR InParanoid; Q8GT06; -.
DR OMA; RTADNCA; -.
DR OrthoDB; 738810at2759; -.
DR Proteomes; UP000000763; Chromosome 1.
DR Proteomes; UP000007752; Chromosome 1.
DR Proteomes; UP000059680; Chromosome 1.
DR Genevisible; Q8GT06; OS.
DR GO; GO:0048476; C:Holliday junction resolvase complex; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0048257; F:3'-flap endonuclease activity; IBA:GO_Central.
DR GO; GO:0008821; F:crossover junction endodeoxyribonuclease activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0000737; P:DNA catabolic process, endonucleolytic; IEA:InterPro.
DR GO; GO:0000727; P:double-strand break repair via break-induced replication; IBA:GO_Central.
DR GO; GO:0031573; P:mitotic intra-S DNA damage checkpoint signaling; IBA:GO_Central.
DR GO; GO:0000712; P:resolution of meiotic recombination intermediates; IBA:GO_Central.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 1.10.150.670; -; 1.
DR InterPro; IPR042530; EME1/EME2_C.
DR InterPro; IPR006166; ERCC4_domain.
DR InterPro; IPR033309; Mus81.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR13451; PTHR13451; 2.
DR Pfam; PF02732; ERCC4; 1.
DR SMART; SM00891; ERCC4; 1.
DR SUPFAM; SSF52980; SSF52980; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Calcium; Cell cycle; Cell division; DNA damage;
KW DNA recombination; DNA repair; DNA-binding; Endonuclease; Hydrolase;
KW Magnesium; Meiosis; Metal-binding; Mitosis; Nuclease; Nucleus;
KW Reference proteome; Repeat.
FT CHAIN 1..660
FT /note="Crossover junction endonuclease MUS81"
FT /id="PRO_0000418425"
FT DOMAIN 411..506
FT /note="ERCC4"
FT REGION 82..109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 62..81
FT /note="Helix-hairpin-helix motif 1"
FT MOTIF 586..623
FT /note="Helix-hairpin-helix motif 2"
FT VAR_SEQ 541..542
FT /note="VR -> FA (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_044049"
FT VAR_SEQ 543..660
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_044050"
FT CONFLICT 269
FT /note="P -> S (in Ref. 7; AK111411)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 660 AA; 73042 MW; 4358540C9CC50C3C CRC64;
MAPEARQLKV HLRENEAVAQ CVLEKWRSME EKPGGLKENL AHTLYKSYRN VCAAKEPIRS
LKDLYQIKGV GKWVIRQLKG SFPESSPDLS PPESNAAGEK GKKAGGSKRY VPQKNSAAYA
ILITLHRETI NGKSHMKKQE LIDATEASGL SRSAIGPDKS KAKPGAFASS QKDWYTGWSC
MKTLTSKGLV AKSGNPAKYM ITEEGKSTAL ECLSRSGLDD HAAPLVINSA PDTSNASHKL
NNICMTSFVE TSSGPSRAIG RPKTSIANPA TKTSPEVTYL TSQESLNYNS DVRTAENCAE
EIILSDSDSE ELYTENYPLI GSEEFTERVA PPILNASNSG KTTTNYRFSD CSASISPRSS
EGTFEMQSSS TMGIAEFNML DNDTVCMDNS ILAMPPRRSS KNFLEDYEVV LILDDRENFG
GRSRKTVDNI HSQFRVPVEI KHLPVGDGIW IARDRKLHTE YVLDFIVERK NVADLCSSIT
DNRYKDQKLR LKKCGLRKLI YLVEGDPNPL DTSERIKTAC FTTEILEGFD VQRTPGYAET
VRTYGNLTHS ITEYYSTHFS TGANTSQVCL TYDEFTKKCD DLKKITVSDV FALQLMQVPQ
VTEEAALAVI GLYPTLFSLA KAYSMLDGDT HAQEKMLKNK STLINAGASR NIFKLVWAEG