ID   MUT11_CHLRE             Reviewed;         370 AA.
AC   Q8W1K8;
DT   20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   25-MAY-2022, entry version 101.
DE   RecName: Full=Protein Mut11;
DE   AltName: Full=Mut11p;
GN   Name=Mut11;
OS   Chlamydomonas reinhardtii (Chlamydomonas smithii).
OC   Eukaryota; Viridiplantae; Chlorophyta; core chlorophytes; Chlorophyceae;
OC   CS clade; Chlamydomonadales; Chlamydomonadaceae; Chlamydomonas.
OX   NCBI_TaxID=3055;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=11782532; DOI=10.1073/pnas.022392999;
RA   Jeong B.-R., Wu-Scharf D., Zhang C., Cerutti H.;
RT   "Suppressors of transcriptional transgenic silencing in Chlamydomonas are
RT   sensitive to DNA-damaging agents and reactivate transposable elements.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:1076-1081(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND SUBCELLULAR LOCATION.
RX   PubMed=12100480; DOI=10.1046/j.1365-313x.2002.01331.x;
RA   Zhang C., Wu-Scharf D., Jeong B.-R., Cerutti H.;
RT   "A WD40-repeat containing protein, similar to a fungal co-repressor, is
RT   required for transcriptional gene silencing in Chlamydomonas.";
RL   Plant J. 31:25-36(2002).
RN   [3]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=16100335; DOI=10.1105/tpc.105.034165;
RA   van Dijk K., Marley K.E., Jeong B.-R., Xu J., Hesson J., Cerny R.L.,
RA   Waterborg J.H., Cerutti H.;
RT   "Monomethyl histone H3 lysine 4 as an epigenetic mark for silenced
RT   euchromatin in Chlamydomonas.";
RL   Plant Cell 17:2439-2453(2005).
CC   -!- FUNCTION: Part of a complex involved in 'Lys-4' histone H3 methylation.
CC       {ECO:0000269|PubMed:16100335}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12100480}.
CC   -!- DISRUPTION PHENOTYPE: Loss of monomethylated, an increase of
CC       dimethylated and a decrease of trimethylated 'Lys-4' histone H3, and
CC       defects in epigenetic silencing. {ECO:0000269|PubMed:16100335}.
CC   -!- SIMILARITY: Belongs to the WD repeat WDR5/wds family. {ECO:0000305}.
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DR   EMBL; AF443204; AAL60198.1; -; mRNA.
DR   RefSeq; XP_001696066.1; XM_001696014.1.
DR   AlphaFoldDB; Q8W1K8; -.
DR   SMR; Q8W1K8; -.
DR   BioGRID; 981498; 11.
DR   STRING; 3055.EDP01015; -.
DR   EnsemblPlants; PNW79810; PNW79810; CHLRE_08g367650v5.
DR   GeneID; 5721692; -.
DR   Gramene; PNW79810; PNW79810; CHLRE_08g367650v5.
DR   KEGG; cre:CHLRE_08g367650v5; -.
DR   eggNOG; KOG0266; Eukaryota.
DR   HOGENOM; CLU_000288_57_1_1; -.
DR   OMA; RLWNYHT; -.
DR   OrthoDB; 957291at2759; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF00400; WD40; 5.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 4.
DR   PROSITE; PS50082; WD_REPEATS_2; 5.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Nucleus; Repeat; WD repeat.
FT   CHAIN           1..370
FT                   /note="Protein Mut11"
FT                   /id="PRO_0000278190"
FT   REPEAT          38..77
FT                   /note="WD 1"
FT   REPEAT          80..119
FT                   /note="WD 2"
FT   REPEAT          122..162
FT                   /note="WD 3"
FT   REPEAT          165..204
FT                   /note="WD 4"
FT   REPEAT          208..247
FT                   /note="WD 5"
FT   REPEAT          262..301
FT                   /note="WD 6"
FT   REPEAT          329..370
FT                   /note="WD 7"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   370 AA;  37749 MW;  8A33515F872B162E CRC64;
     MARGPGDTDM DEASADAAIP SSTPNPTVAF RCTHALSGHT KAVAAVKFSP DGSLLASGSA
     DRTVALWDAA TGARVNTLAG HSCGVSDVAW NPNGRYLATA ADDHSLKLWD AETGACLRTL
     TGHTNYVFCC NFDGAAGHLL ASGSFDETLR LWDVRSGRCL REVPAHSDPV TSAAFSYDGS
     MVVTSSLDGL IRLWDTQTGH CLKTLFDRDS PPVSFAAFTP NAKYVLCNTL DGRAKLWDYA
     AGRTRRTYAG GHVNTQFCIS SGFLGGSSSA SFDLGCSMVV TGSEDGSLAA YDISTGHVVG
     RGAAAAAAAE GGGDEGSAAA AAAGGVAGGH TAAVLSVNVH PSAPLVATGG HHPDNSVRVW
     AASRTEPAAA