ID   A12_VARV                Reviewed;         189 AA.
AC   P0DOL0; P33837;
DT   16-OCT-2019, integrated into UniProtKB/Swiss-Prot.
DT   16-OCT-2019, sequence version 1.
DT   23-FEB-2022, entry version 11.
DE   RecName: Full=25 kDa core protein A12L;
DE   Contains:
DE     RecName: Full=17 kDa core protein A12L;
DE              Short=17K;
GN   ORFNames=A12L;
OS   Variola virus.
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus.
OX   NCBI_TaxID=10255;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Bangladesh-1975;
RX   PubMed=8264798; DOI=10.1038/366748a0;
RA   Massung R.F., Esposito J.J., Liu L.I., Qi J., Utterback T.R., Knight J.C.,
RA   Aubin L., Yuran T.E., Parsons J.M., Loparev V.N., Selivanov N.A.,
RA   Cavallaro K.F., Kerlavage A.R., Mahy B.W.J., Venter J.C.;
RT   "Potential virulence determinants in terminal regions of variola smallpox
RT   virus genome.";
RL   Nature 366:748-751(1993).
CC   -!- FUNCTION: Component of the virion core that undergoes proteolytic
CC       processing during the immature virion (IV) to mature virion (MV)
CC       transition. Essential for the formation of a structurally normal core
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: [25 kDa core protein A12L]: Virion {ECO:0000250}.
CC       Note=Localizes to the virion core. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: [17 kDa core protein A12L]: Virion {ECO:0000250}.
CC       Note=Localizes to the virion core. {ECO:0000250}.
CC   -!- INDUCTION: Expressed in the late phase of the viral replicative cycle.
CC   -!- PTM: The 25-kDa precursor is cleaved to a mature protein of 17 kDa
CC       during virion maturation. Further proteolytic processing is supposed to
CC       occur since five more A12L-derived products have been observed (By
CC       similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the chordopoxvirinae A12 family. {ECO:0000305}.
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DR   EMBL; L22579; AAA60864.1; -; Genomic_DNA.
DR   PIR; T28554; T28554.
DR   RefSeq; NP_042160.1; NC_001611.1.
DR   SMR; P0DOL0; -.
DR   GeneID; 1486487; -.
DR   KEGG; vg:1486487; -.
DR   Proteomes; UP000119805; Genome.
DR   InterPro; IPR006744; Poxvirus_A12.
DR   Pfam; PF04651; Pox_A12; 1.
PE   2: Evidence at transcript level;
KW   Late protein; Virion.
FT   CHAIN           1..189
FT                   /note="25 kDa core protein A12L"
FT                   /id="PRO_0000448226"
FT   CHAIN           1..56
FT                   /note="17 kDa core protein A12L"
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000448228"
FT   REGION          69..102
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          151..173
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   SITE            56..57
FT                   /note="Cleavage; by I7 protease"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   189 AA;  20192 MW;  A3092B675BEA0C63 CRC64;
     MADKKNLAVR SSYDDYIETV NKITPQLKNL LAQIGGDAAV KGGNNNLNSQ TDVTAGACDT
     KSKSSKCITC KSKSSSSSTS TSKSSKNTSG APRRRTTATT SFNAMDGQIV QAVTNAGKIV
     YGTVRDGQLE VRGMVGEINH DLLGIESVNA GKKKPSKKMP TNKKINMSSG MRRQEQINPN
     DCCLDMGMY