ID   MUTH_BUCBP              Reviewed;         220 AA.
AC   Q89B33;
DT   13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=DNA mismatch repair protein MutH {ECO:0000255|HAMAP-Rule:MF_00759};
DE   AltName: Full=Methyl-directed mismatch repair protein {ECO:0000255|HAMAP-Rule:MF_00759};
GN   Name=mutH {ECO:0000255|HAMAP-Rule:MF_00759}; OrderedLocusNames=bbp_018;
OS   Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Erwiniaceae; Buchnera.
OX   NCBI_TaxID=224915;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bp;
RX   PubMed=12522265; DOI=10.1073/pnas.0235981100;
RA   van Ham R.C.H.J., Kamerbeek J., Palacios C., Rausell C., Abascal F.,
RA   Bastolla U., Fernandez J.M., Jimenez L., Postigo M., Silva F.J.,
RA   Tamames J., Viguera E., Latorre A., Valencia A., Moran F., Moya A.;
RT   "Reductive genome evolution in Buchnera aphidicola.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:581-586(2003).
CC   -!- FUNCTION: Sequence-specific endonuclease that cleaves unmethylated GATC
CC       sequences. It is involved in DNA mismatch repair. {ECO:0000255|HAMAP-
CC       Rule:MF_00759}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00759}.
CC   -!- SIMILARITY: Belongs to the MutH family. {ECO:0000255|HAMAP-
CC       Rule:MF_00759}.
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DR   EMBL; AE016826; AAO26762.1; -; Genomic_DNA.
DR   RefSeq; WP_011091163.1; NC_004545.1.
DR   AlphaFoldDB; Q89B33; -.
DR   SMR; Q89B33; -.
DR   STRING; 224915.bbp_018; -.
DR   EnsemblBacteria; AAO26762; AAO26762; bbp_018.
DR   KEGG; bab:bbp_018; -.
DR   eggNOG; COG3066; Bacteria.
DR   HOGENOM; CLU_086669_0_0_6; -.
DR   OMA; EVMQLRP; -.
DR   OrthoDB; 1154974at2; -.
DR   Proteomes; UP000000601; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006304; P:DNA modification; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   CDD; cd00583; MutH_Sau3AI; 1.
DR   Gene3D; 3.40.600.10; -; 1.
DR   HAMAP; MF_00759; MutH; 1.
DR   InterPro; IPR004230; DNA_mismatch_repair_MutH.
DR   InterPro; IPR011337; DNA_rep_MutH/RE_typeII_Sau3AI.
DR   InterPro; IPR037057; DNA_rep_MutH/T2_RE_sf.
DR   InterPro; IPR011335; Restrct_endonuc-II-like.
DR   Pfam; PF02976; MutH; 1.
DR   SMART; SM00927; MutH; 1.
DR   SUPFAM; SSF52980; SSF52980; 1.
DR   TIGRFAMs; TIGR02248; mutH_TIGR; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA repair; Endonuclease; Hydrolase; Nuclease;
KW   Reference proteome.
FT   CHAIN           1..220
FT                   /note="DNA mismatch repair protein MutH"
FT                   /id="PRO_0000198664"
SQ   SEQUENCE   220 AA;  25340 MW;  13A189CC7E04ADAC CRC64;
     MCVFCEKKLF MHAIGLSGYS IREIVSSLDQ PVSNSLVRNK GFVGKILELI LGVNVLHGYK
     CIDFPSLGIE LKSIPINSSG YPLEPTFICN IPLKNNSLNI TWNNSYFYRK IKKILWIPII
     GNRVVSFLDK IVGEAFIWTM SSVQEKILKK DWEEFMDLII IGKVEYISSK HGQVLQVKKK
     CKNKHVCIKF INYNGCVKFT NPRAFYFRKS FTWSLLNLSK