ID   MUTH_ECO57              Reviewed;         229 AA.
AC   Q8X6K2;
DT   13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   03-AUG-2022, entry version 114.
DE   RecName: Full=DNA mismatch repair protein MutH {ECO:0000255|HAMAP-Rule:MF_00759};
DE   AltName: Full=Methyl-directed mismatch repair protein {ECO:0000255|HAMAP-Rule:MF_00759};
GN   Name=mutH {ECO:0000255|HAMAP-Rule:MF_00759};
GN   OrderedLocusNames=Z4149, ECs3688;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA   Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA   Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA   Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA   Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA   Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA   Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA   Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT   genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- FUNCTION: Sequence-specific endonuclease that cleaves unmethylated GATC
CC       sequences. It is involved in DNA mismatch repair. {ECO:0000255|HAMAP-
CC       Rule:MF_00759}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00759}.
CC   -!- SIMILARITY: Belongs to the MutH family. {ECO:0000255|HAMAP-
CC       Rule:MF_00759}.
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DR   EMBL; AE005174; AAG57943.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB37111.1; -; Genomic_DNA.
DR   PIR; C85935; C85935.
DR   PIR; H91089; H91089.
DR   RefSeq; NP_311715.1; NC_002695.1.
DR   RefSeq; WP_000082188.1; NZ_SWKA01000005.1.
DR   AlphaFoldDB; Q8X6K2; -.
DR   SMR; Q8X6K2; -.
DR   STRING; 155864.EDL933_4011; -.
DR   EnsemblBacteria; AAG57943; AAG57943; Z4149.
DR   EnsemblBacteria; BAB37111; BAB37111; ECs_3688.
DR   GeneID; 66673302; -.
DR   GeneID; 916491; -.
DR   KEGG; ece:Z4149; -.
DR   KEGG; ecs:ECs_3688; -.
DR   PATRIC; fig|386585.9.peg.3855; -.
DR   eggNOG; COG3066; Bacteria.
DR   HOGENOM; CLU_086669_0_0_6; -.
DR   OMA; EVMQLRP; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006304; P:DNA modification; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   CDD; cd00583; MutH_Sau3AI; 1.
DR   Gene3D; 3.40.600.10; -; 1.
DR   HAMAP; MF_00759; MutH; 1.
DR   InterPro; IPR004230; DNA_mismatch_repair_MutH.
DR   InterPro; IPR011337; DNA_rep_MutH/RE_typeII_Sau3AI.
DR   InterPro; IPR037057; DNA_rep_MutH/T2_RE_sf.
DR   InterPro; IPR011335; Restrct_endonuc-II-like.
DR   Pfam; PF02976; MutH; 1.
DR   SMART; SM00927; MutH; 1.
DR   SUPFAM; SSF52980; SSF52980; 1.
DR   TIGRFAMs; TIGR02248; mutH_TIGR; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA repair; Endonuclease; Hydrolase; Nuclease;
KW   Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..229
FT                   /note="DNA mismatch repair protein MutH"
FT                   /id="PRO_0000198667"
SQ   SEQUENCE   229 AA;  25499 MW;  20D2BD945E962CED CRC64;
     MSQPRPLLSP PETEEQLLAQ AQQLSGYTLG ELAALAGLVT PENLKRDKGW IGVLLEIWLG
     ASAGSKPEQD FAALGVELKT IPVDSLGRPL ETTFVCVAPL TGNSGVTWET SHVRHKLKRV
     LWIPVEGERS IPLAQRRVGS PLLWSPNEEE DRQLREDWEE LMDMIVLGQV ERITARHGEY
     LQIRPKAANA KALTEAIGAR GERILTLPRG FYLKKNFTSA LLARHFLIQ