ID   MUTH_ECOHS              Reviewed;         229 AA.
AC   A8A3W5;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-OCT-2007, sequence version 1.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=DNA mismatch repair protein MutH {ECO:0000255|HAMAP-Rule:MF_00759};
DE   AltName: Full=Methyl-directed mismatch repair protein {ECO:0000255|HAMAP-Rule:MF_00759};
GN   Name=mutH {ECO:0000255|HAMAP-Rule:MF_00759}; OrderedLocusNames=EcHS_A2978;
OS   Escherichia coli O9:H4 (strain HS).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=331112;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HS;
RX   PubMed=18676672; DOI=10.1128/jb.00619-08;
RA   Rasko D.A., Rosovitz M.J., Myers G.S.A., Mongodin E.F., Fricke W.F.,
RA   Gajer P., Crabtree J., Sebaihia M., Thomson N.R., Chaudhuri R.,
RA   Henderson I.R., Sperandio V., Ravel J.;
RT   "The pangenome structure of Escherichia coli: comparative genomic analysis
RT   of E. coli commensal and pathogenic isolates.";
RL   J. Bacteriol. 190:6881-6893(2008).
CC   -!- FUNCTION: Sequence-specific endonuclease that cleaves unmethylated GATC
CC       sequences. It is involved in DNA mismatch repair. {ECO:0000255|HAMAP-
CC       Rule:MF_00759}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00759}.
CC   -!- SIMILARITY: Belongs to the MutH family. {ECO:0000255|HAMAP-
CC       Rule:MF_00759}.
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DR   EMBL; CP000802; ABV07219.1; -; Genomic_DNA.
DR   RefSeq; WP_000082201.1; NC_009800.1.
DR   AlphaFoldDB; A8A3W5; -.
DR   SMR; A8A3W5; -.
DR   KEGG; ecx:EcHS_A2978; -.
DR   HOGENOM; CLU_086669_0_0_6; -.
DR   OMA; EVMQLRP; -.
DR   Proteomes; UP000001123; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006304; P:DNA modification; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   CDD; cd00583; MutH_Sau3AI; 1.
DR   Gene3D; 3.40.600.10; -; 1.
DR   HAMAP; MF_00759; MutH; 1.
DR   InterPro; IPR004230; DNA_mismatch_repair_MutH.
DR   InterPro; IPR011337; DNA_rep_MutH/RE_typeII_Sau3AI.
DR   InterPro; IPR037057; DNA_rep_MutH/T2_RE_sf.
DR   InterPro; IPR011335; Restrct_endonuc-II-like.
DR   Pfam; PF02976; MutH; 1.
DR   SMART; SM00927; MutH; 1.
DR   SUPFAM; SSF52980; SSF52980; 1.
DR   TIGRFAMs; TIGR02248; mutH_TIGR; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA repair; Endonuclease; Hydrolase; Nuclease.
FT   CHAIN           1..229
FT                   /note="DNA mismatch repair protein MutH"
FT                   /id="PRO_1000062203"
SQ   SEQUENCE   229 AA;  25527 MW;  32543989D710A8FD CRC64;
     MSQPRPLLSP PETEEQLLAQ AQQLSGYTLG ELAALVGLVT PENLKRDKGW IGVLLEIWLG
     ASAGSKPEQD FAALGVELKT IPVDSLGRPL ETTFVCVAPL TGNSGVTWET SHVRHKLKRV
     LWIPVEGERS IPLAQRRVGS PLLWSPNEEE DRQLREDWEE LMDMIVLGQV ERITARHGEY
     LQIRPKAANA KALTEAIGAR GERILTLPRG FYLKKNFTSA LLARHFLIQ