MUTH_HAEDU
ID MUTH_HAEDU Reviewed; 226 AA.
AC Q7VNI7;
DT 13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=DNA mismatch repair protein MutH {ECO:0000255|HAMAP-Rule:MF_00759};
DE AltName: Full=Methyl-directed mismatch repair protein {ECO:0000255|HAMAP-Rule:MF_00759};
GN Name=mutH {ECO:0000255|HAMAP-Rule:MF_00759}; OrderedLocusNames=HD_0544;
OS Haemophilus ducreyi (strain 35000HP / ATCC 700724).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Haemophilus.
OX NCBI_TaxID=233412;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=35000HP / ATCC 700724;
RA Munson R.S. Jr., Ray W.C., Mahairas G., Sabo P., Mungur R., Johnson L.,
RA Nguyen D., Wang J., Forst C., Hood L.;
RT "The complete genome sequence of Haemophilus ducreyi.";
RL Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Sequence-specific endonuclease that cleaves unmethylated GATC
CC sequences. It is involved in DNA mismatch repair. {ECO:0000255|HAMAP-
CC Rule:MF_00759}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00759}.
CC -!- SIMILARITY: Belongs to the MutH family. {ECO:0000255|HAMAP-
CC Rule:MF_00759}.
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DR EMBL; AE017143; AAP95483.1; -; Genomic_DNA.
DR RefSeq; WP_010944536.1; NC_002940.2.
DR AlphaFoldDB; Q7VNI7; -.
DR SMR; Q7VNI7; -.
DR STRING; 233412.HD_0544; -.
DR EnsemblBacteria; AAP95483; AAP95483; HD_0544.
DR KEGG; hdu:HD_0544; -.
DR eggNOG; COG3066; Bacteria.
DR HOGENOM; CLU_086669_0_0_6; -.
DR OMA; EVMQLRP; -.
DR Proteomes; UP000001022; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006304; P:DNA modification; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd00583; MutH_Sau3AI; 1.
DR Gene3D; 3.40.600.10; -; 1.
DR HAMAP; MF_00759; MutH; 1.
DR InterPro; IPR004230; DNA_mismatch_repair_MutH.
DR InterPro; IPR011337; DNA_rep_MutH/RE_typeII_Sau3AI.
DR InterPro; IPR037057; DNA_rep_MutH/T2_RE_sf.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR Pfam; PF02976; MutH; 1.
DR SMART; SM00927; MutH; 1.
DR SUPFAM; SSF52980; SSF52980; 1.
DR TIGRFAMs; TIGR02248; mutH_TIGR; 1.
PE 3: Inferred from homology;
KW Cytoplasm; DNA damage; DNA repair; Endonuclease; Hydrolase; Nuclease;
KW Reference proteome.
FT CHAIN 1..226
FT /note="DNA mismatch repair protein MutH"
FT /id="PRO_0000198668"
SQ SEQUENCE 226 AA; 25732 MW; 0477FDBFC88A960F CRC64;
MQLSIQPQSE AELLAKANWL AGFTLGELAQ QLNTVVPPDL TRDKGWVGQI IERALGATAG
SKPEQDFAHL GIELKTIPIN NHGLPLETTF ICLAPLIHNQ GITWQTSHVK YKLQRVLWIP
IQAERSIPIK DRYIGRAILW SPSYQQEQQL RNDWEELMEY IVLGRLDQIN GHLGEVMQLR
PKGRNRLSIT QSIDQHGEQI QSLPLAFYLR KPFTAAILQN FLQQSD