ID   MUTH_HAEIN              Reviewed;         223 AA.
AC   P44688;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 124.
DE   RecName: Full=DNA mismatch repair protein MutH {ECO:0000255|HAMAP-Rule:MF_00759};
DE   AltName: Full=Methyl-directed mismatch repair protein {ECO:0000255|HAMAP-Rule:MF_00759};
GN   Name=mutH {ECO:0000255|HAMAP-Rule:MF_00759}; OrderedLocusNames=HI_0403;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
CC   -!- FUNCTION: Sequence-specific endonuclease that cleaves unmethylated GATC
CC       sequences. It is involved in DNA mismatch repair. {ECO:0000255|HAMAP-
CC       Rule:MF_00759}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00759}.
CC   -!- SIMILARITY: Belongs to the MutH family. {ECO:0000255|HAMAP-
CC       Rule:MF_00759}.
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DR   EMBL; L42023; AAC22062.1; -; Genomic_DNA.
DR   PIR; H64065; H64065.
DR   RefSeq; NP_438565.1; NC_000907.1.
DR   RefSeq; WP_005693765.1; NC_000907.1.
DR   PDB; 2AOQ; X-ray; 2.20 A; A=1-223.
DR   PDB; 2AOR; X-ray; 2.00 A; A/B=1-223.
DR   PDBsum; 2AOQ; -.
DR   PDBsum; 2AOR; -.
DR   AlphaFoldDB; P44688; -.
DR   SMR; P44688; -.
DR   STRING; 71421.HI_0403; -.
DR   EnsemblBacteria; AAC22062; AAC22062; HI_0403.
DR   KEGG; hin:HI_0403; -.
DR   PATRIC; fig|71421.8.peg.422; -.
DR   eggNOG; COG3066; Bacteria.
DR   HOGENOM; CLU_086669_0_0_6; -.
DR   OMA; EVMQLRP; -.
DR   PhylomeDB; P44688; -.
DR   BioCyc; HINF71421:G1GJ1-418-MON; -.
DR   EvolutionaryTrace; P44688; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006304; P:DNA modification; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   CDD; cd00583; MutH_Sau3AI; 1.
DR   Gene3D; 3.40.600.10; -; 1.
DR   HAMAP; MF_00759; MutH; 1.
DR   InterPro; IPR004230; DNA_mismatch_repair_MutH.
DR   InterPro; IPR011337; DNA_rep_MutH/RE_typeII_Sau3AI.
DR   InterPro; IPR037057; DNA_rep_MutH/T2_RE_sf.
DR   InterPro; IPR011335; Restrct_endonuc-II-like.
DR   Pfam; PF02976; MutH; 1.
DR   SMART; SM00927; MutH; 1.
DR   SUPFAM; SSF52980; SSF52980; 1.
DR   TIGRFAMs; TIGR02248; mutH_TIGR; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Cytoplasm; DNA damage; DNA repair; Endonuclease; Hydrolase;
KW   Nuclease; Reference proteome.
FT   CHAIN           1..223
FT                   /note="DNA mismatch repair protein MutH"
FT                   /id="PRO_0000198669"
FT   HELIX           6..16
FT                   /evidence="ECO:0007829|PDB:2AOR"
FT   HELIX           21..27
FT                   /evidence="ECO:0007829|PDB:2AOR"
FT   HELIX           42..51
FT                   /evidence="ECO:0007829|PDB:2AOR"
FT   STRAND          59..61
FT                   /evidence="ECO:0007829|PDB:2AOR"
FT   TURN            64..67
FT                   /evidence="ECO:0007829|PDB:2AOR"
FT   STRAND          68..75
FT                   /evidence="ECO:0007829|PDB:2AOR"
FT   STRAND          81..83
FT                   /evidence="ECO:0007829|PDB:2AOR"
FT   STRAND          85..89
FT                   /evidence="ECO:0007829|PDB:2AOR"
FT   HELIX           100..102
FT                   /evidence="ECO:0007829|PDB:2AOQ"
FT   HELIX           104..109
FT                   /evidence="ECO:0007829|PDB:2AOR"
FT   STRAND          110..118
FT                   /evidence="ECO:0007829|PDB:2AOR"
FT   HELIX           125..127
FT                   /evidence="ECO:0007829|PDB:2AOR"
FT   STRAND          134..136
FT                   /evidence="ECO:0007829|PDB:2AOR"
FT   HELIX           140..158
FT                   /evidence="ECO:0007829|PDB:2AOR"
FT   HELIX           162..164
FT                   /evidence="ECO:0007829|PDB:2AOR"
FT   STRAND          171..177
FT                   /evidence="ECO:0007829|PDB:2AOR"
FT   STRAND          179..181
FT                   /evidence="ECO:0007829|PDB:2AOR"
FT   STRAND          186..189
FT                   /evidence="ECO:0007829|PDB:2AOR"
FT   STRAND          195..198
FT                   /evidence="ECO:0007829|PDB:2AOR"
FT   STRAND          201..205
FT                   /evidence="ECO:0007829|PDB:2AOR"
FT   HELIX           207..218
FT                   /evidence="ECO:0007829|PDB:2AOR"
SQ   SEQUENCE   223 AA;  24906 MW;  339A4EF9DA0E622A CRC64;
     MIPQTLEQLL SQAQSIAGLT FGELADELHI PVPIDLKRDK GWVGMLLERA LGATAGSKAE
     QDFSHLGVEL KTLPINAEGY PLETTFVSLA PLVQNSGVKW ENSHVRHKLS CVLWMPIEGS
     RHIPLRERHI GAPIFWKPTA EQERQLKQDW EELMDLIVLG KLDQITARIG EVMQLRPKGA
     NSRAVTKGIG KNGEIIDTLP LGFYLRKEFT AQILNAFLET KSL