MUTH_HISS2
ID MUTH_HISS2 Reviewed; 224 AA.
AC B0URN6;
DT 28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 08-APR-2008, sequence version 1.
DT 03-AUG-2022, entry version 85.
DE RecName: Full=DNA mismatch repair protein MutH {ECO:0000255|HAMAP-Rule:MF_00759};
DE AltName: Full=Methyl-directed mismatch repair protein {ECO:0000255|HAMAP-Rule:MF_00759};
GN Name=mutH {ECO:0000255|HAMAP-Rule:MF_00759}; OrderedLocusNames=HSM_0474;
OS Histophilus somni (strain 2336) (Haemophilus somnus).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Histophilus.
OX NCBI_TaxID=228400;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2336;
RG US DOE Joint Genome Institute;
RA Siddaramappa S., Duncan A.J., Challacombe J.F., Rainey D., Gillaspy A.F.,
RA Carson M., Gipson J., Gipson M., Bruce D., Detter J.C., Han C.S., Land M.,
RA Tapia R., Thompson L.S., Orvis J., Zaitshik J., Barnes G., Brettin T.S.,
RA Dyer D.W., Inzana T.J.;
RT "Complete sequence of Haemophilus somnus 2336.";
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Sequence-specific endonuclease that cleaves unmethylated GATC
CC sequences. It is involved in DNA mismatch repair. {ECO:0000255|HAMAP-
CC Rule:MF_00759}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00759}.
CC -!- SIMILARITY: Belongs to the MutH family. {ECO:0000255|HAMAP-
CC Rule:MF_00759}.
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DR EMBL; CP000947; ACA32120.1; -; Genomic_DNA.
DR RefSeq; WP_012341312.1; NC_010519.1.
DR AlphaFoldDB; B0URN6; -.
DR SMR; B0URN6; -.
DR STRING; 228400.HSM_0474; -.
DR EnsemblBacteria; ACA32120; ACA32120; HSM_0474.
DR GeneID; 56965611; -.
DR KEGG; hsm:HSM_0474; -.
DR HOGENOM; CLU_086669_0_0_6; -.
DR OMA; EVMQLRP; -.
DR OrthoDB; 1154974at2; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006304; P:DNA modification; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd00583; MutH_Sau3AI; 1.
DR Gene3D; 3.40.600.10; -; 1.
DR HAMAP; MF_00759; MutH; 1.
DR InterPro; IPR004230; DNA_mismatch_repair_MutH.
DR InterPro; IPR011337; DNA_rep_MutH/RE_typeII_Sau3AI.
DR InterPro; IPR037057; DNA_rep_MutH/T2_RE_sf.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR Pfam; PF02976; MutH; 1.
DR SMART; SM00927; MutH; 1.
DR SUPFAM; SSF52980; SSF52980; 1.
DR TIGRFAMs; TIGR02248; mutH_TIGR; 1.
PE 3: Inferred from homology;
KW Cytoplasm; DNA damage; DNA repair; Endonuclease; Hydrolase; Nuclease.
FT CHAIN 1..224
FT /note="DNA mismatch repair protein MutH"
FT /id="PRO_1000148401"
SQ SEQUENCE 224 AA; 24996 MW; D6938F035A2EAC86 CRC64;
MTALTPPQHE AELLQRAKSI AGLTFAELAE ELNLVVPPDL KRDKGWVGML IETALGATAG
SKAEQDFSHL GIELKTIPVN QQGYPLETTF VSLAPLAQNS GVTWHSSHVR YKLSKVLWIP
IEGERQIPLA ERHVGVPILW QPSSSQEQRL RQDWEELMDY IVLGKLTEIT ARIGEVLQLR
PKGANSRALT KGIGKNGEII DTLPLGFYLR KEFTAEILHD FLMD