MUTH_KLEP3
ID MUTH_KLEP3 Reviewed; 231 AA.
AC B5XUP7;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 25-NOV-2008, sequence version 1.
DT 03-AUG-2022, entry version 68.
DE RecName: Full=DNA mismatch repair protein MutH {ECO:0000255|HAMAP-Rule:MF_00759};
DE AltName: Full=Methyl-directed mismatch repair protein {ECO:0000255|HAMAP-Rule:MF_00759};
GN Name=mutH {ECO:0000255|HAMAP-Rule:MF_00759}; OrderedLocusNames=KPK_0874;
OS Klebsiella pneumoniae (strain 342).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX NCBI_TaxID=507522;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=342;
RX PubMed=18654632; DOI=10.1371/journal.pgen.1000141;
RA Fouts D.E., Tyler H.L., DeBoy R.T., Daugherty S., Ren Q., Badger J.H.,
RA Durkin A.S., Huot H., Shrivastava S., Kothari S., Dodson R.J., Mohamoud Y.,
RA Khouri H., Roesch L.F.W., Krogfelt K.A., Struve C., Triplett E.W.,
RA Methe B.A.;
RT "Complete genome sequence of the N2-fixing broad host range endophyte
RT Klebsiella pneumoniae 342 and virulence predictions verified in mice.";
RL PLoS Genet. 4:E1000141-E1000141(2008).
CC -!- FUNCTION: Sequence-specific endonuclease that cleaves unmethylated GATC
CC sequences. It is involved in DNA mismatch repair. {ECO:0000255|HAMAP-
CC Rule:MF_00759}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00759}.
CC -!- SIMILARITY: Belongs to the MutH family. {ECO:0000255|HAMAP-
CC Rule:MF_00759}.
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DR EMBL; CP000964; ACI07393.1; -; Genomic_DNA.
DR AlphaFoldDB; B5XUP7; -.
DR SMR; B5XUP7; -.
DR PRIDE; B5XUP7; -.
DR EnsemblBacteria; ACI07393; ACI07393; KPK_0874.
DR KEGG; kpe:KPK_0874; -.
DR HOGENOM; CLU_086669_0_0_6; -.
DR OMA; EVMQLRP; -.
DR OrthoDB; 1154974at2; -.
DR Proteomes; UP000001734; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006304; P:DNA modification; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd00583; MutH_Sau3AI; 1.
DR Gene3D; 3.40.600.10; -; 1.
DR HAMAP; MF_00759; MutH; 1.
DR InterPro; IPR004230; DNA_mismatch_repair_MutH.
DR InterPro; IPR011337; DNA_rep_MutH/RE_typeII_Sau3AI.
DR InterPro; IPR037057; DNA_rep_MutH/T2_RE_sf.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR Pfam; PF02976; MutH; 1.
DR SMART; SM00927; MutH; 1.
DR SUPFAM; SSF52980; SSF52980; 1.
DR TIGRFAMs; TIGR02248; mutH_TIGR; 1.
PE 3: Inferred from homology;
KW Cytoplasm; DNA damage; DNA repair; Endonuclease; Hydrolase; Nuclease.
FT CHAIN 1..231
FT /note="DNA mismatch repair protein MutH"
FT /id="PRO_1000133468"
SQ SEQUENCE 231 AA; 25493 MW; FDAD4A1FC450EFE2 CRC64;
MPTIAPLSSP PQSQEQLLAQ ARQLAGYSLG ELAALAGIPI PRDLKRDKGW TGILLELWLG
ASAGSKPEQD FAALGVELKT IPIDSRGRPL ETTFVCVAPL TGNSGVTWES SHVRHKLQRV
LWIPVEGERT IPLAARRVGA PLLWSPDEDE ERQLRMDWEE LMDLIVLGEV ERITARHGEV
LQLRPKAANS KALTEAIGAH GETILTLPRG FYLKKNFTAA LLARHFLLQH D