ID   MUTH_SHESA              Reviewed;         223 AA.
AC   A0KZQ0;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   12-DEC-2006, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=DNA mismatch repair protein MutH {ECO:0000255|HAMAP-Rule:MF_00759};
DE   AltName: Full=Methyl-directed mismatch repair protein {ECO:0000255|HAMAP-Rule:MF_00759};
GN   Name=mutH {ECO:0000255|HAMAP-Rule:MF_00759};
GN   OrderedLocusNames=Shewana3_3044;
OS   Shewanella sp. (strain ANA-3).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Alteromonadales;
OC   Shewanellaceae; Shewanella.
OX   NCBI_TaxID=94122;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ANA-3;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Chertkov O., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Newman D.,
RA   Salticov C., Konstantinidis K., Klappenback J., Tiedje J., Richardson P.;
RT   "Complete sequence of chromosome 1 of Shewanella sp. ANA-3.";
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Sequence-specific endonuclease that cleaves unmethylated GATC
CC       sequences. It is involved in DNA mismatch repair. {ECO:0000255|HAMAP-
CC       Rule:MF_00759}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00759}.
CC   -!- SIMILARITY: Belongs to the MutH family. {ECO:0000255|HAMAP-
CC       Rule:MF_00759}.
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DR   EMBL; CP000469; ABK49269.1; -; Genomic_DNA.
DR   RefSeq; WP_011717889.1; NC_008577.1.
DR   AlphaFoldDB; A0KZQ0; -.
DR   SMR; A0KZQ0; -.
DR   STRING; 94122.Shewana3_3044; -.
DR   EnsemblBacteria; ABK49269; ABK49269; Shewana3_3044.
DR   KEGG; shn:Shewana3_3044; -.
DR   eggNOG; COG3066; Bacteria.
DR   HOGENOM; CLU_086669_0_0_6; -.
DR   OMA; EVMQLRP; -.
DR   OrthoDB; 1154974at2; -.
DR   Proteomes; UP000002589; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006304; P:DNA modification; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   CDD; cd00583; MutH_Sau3AI; 1.
DR   Gene3D; 3.40.600.10; -; 1.
DR   HAMAP; MF_00759; MutH; 1.
DR   InterPro; IPR004230; DNA_mismatch_repair_MutH.
DR   InterPro; IPR011337; DNA_rep_MutH/RE_typeII_Sau3AI.
DR   InterPro; IPR037057; DNA_rep_MutH/T2_RE_sf.
DR   InterPro; IPR011335; Restrct_endonuc-II-like.
DR   Pfam; PF02976; MutH; 1.
DR   SMART; SM00927; MutH; 1.
DR   SUPFAM; SSF52980; SSF52980; 1.
DR   TIGRFAMs; TIGR02248; mutH_TIGR; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA repair; Endonuclease; Hydrolase; Nuclease.
FT   CHAIN           1..223
FT                   /note="DNA mismatch repair protein MutH"
FT                   /id="PRO_1000046709"
SQ   SEQUENCE   223 AA;  24840 MW;  51A6532CFB713670 CRC64;
     MKPIIPPQNL SELLERANMM AGISLAQIAA HRGIAVPKDL KRDKGWVGQL IEMELGATAG
     SKPEQDFLHL GVELKTIPID SKGKPLETTY VCVAPLTNIE GLTWQDSLVC HKLQRVLWVP
     VEGERHIPVG DRRVGTPILW EPDLQEQRLL QQDWEEIMEL IALGKVEKLT ARHGEVLQLR
     PKAANSKALT QSIAEDGSLK MTNPRGFYLK TAFTAMLLNK VFG