MUTH_YERE8
ID MUTH_YERE8 Reviewed; 228 AA.
AC A1JPE3;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 06-FEB-2007, sequence version 1.
DT 03-AUG-2022, entry version 84.
DE RecName: Full=DNA mismatch repair protein MutH {ECO:0000255|HAMAP-Rule:MF_00759};
DE AltName: Full=Methyl-directed mismatch repair protein {ECO:0000255|HAMAP-Rule:MF_00759};
GN Name=mutH {ECO:0000255|HAMAP-Rule:MF_00759}; OrderedLocusNames=YE3322;
OS Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 /
OS 8081).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Yersiniaceae; Yersinia.
OX NCBI_TaxID=393305;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC 13174 / 8081;
RX PubMed=17173484; DOI=10.1371/journal.pgen.0020206;
RA Thomson N.R., Howard S., Wren B.W., Holden M.T.G., Crossman L.,
RA Challis G.L., Churcher C., Mungall K., Brooks K., Chillingworth T.,
RA Feltwell T., Abdellah Z., Hauser H., Jagels K., Maddison M., Moule S.,
RA Sanders M., Whitehead S., Quail M.A., Dougan G., Parkhill J.,
RA Prentice M.B.;
RT "The complete genome sequence and comparative genome analysis of the high
RT pathogenicity Yersinia enterocolitica strain 8081.";
RL PLoS Genet. 2:2039-2051(2006).
CC -!- FUNCTION: Sequence-specific endonuclease that cleaves unmethylated GATC
CC sequences. It is involved in DNA mismatch repair. {ECO:0000255|HAMAP-
CC Rule:MF_00759}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00759}.
CC -!- SIMILARITY: Belongs to the MutH family. {ECO:0000255|HAMAP-
CC Rule:MF_00759}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AM286415; CAL13351.1; -; Genomic_DNA.
DR RefSeq; WP_005165371.1; NC_008800.1.
DR RefSeq; YP_001007495.1; NC_008800.1.
DR AlphaFoldDB; A1JPE3; -.
DR SMR; A1JPE3; -.
DR STRING; 393305.YE3322; -.
DR EnsemblBacteria; CAL13351; CAL13351; YE3322.
DR KEGG; yen:YE3322; -.
DR PATRIC; fig|393305.7.peg.3530; -.
DR eggNOG; COG3066; Bacteria.
DR HOGENOM; CLU_086669_0_0_6; -.
DR OMA; EVMQLRP; -.
DR Proteomes; UP000000642; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006304; P:DNA modification; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd00583; MutH_Sau3AI; 1.
DR Gene3D; 3.40.600.10; -; 1.
DR HAMAP; MF_00759; MutH; 1.
DR InterPro; IPR004230; DNA_mismatch_repair_MutH.
DR InterPro; IPR011337; DNA_rep_MutH/RE_typeII_Sau3AI.
DR InterPro; IPR037057; DNA_rep_MutH/T2_RE_sf.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR Pfam; PF02976; MutH; 1.
DR SMART; SM00927; MutH; 1.
DR SUPFAM; SSF52980; SSF52980; 1.
DR TIGRFAMs; TIGR02248; mutH_TIGR; 1.
PE 3: Inferred from homology;
KW Cytoplasm; DNA damage; DNA repair; Endonuclease; Hydrolase; Nuclease.
FT CHAIN 1..228
FT /note="DNA mismatch repair protein MutH"
FT /id="PRO_1000046718"
SQ SEQUENCE 228 AA; 25322 MW; F08E3107D463E763 CRC64;
MSVYSLPPAP PTDEHQLFQR AEALSGFTLG ELASKAGWNI PADLKRIKGW VGMLLEFYLG
ASAGSKPEQD FADIGIELKT IPISAQGKPL ETTFVCVAPL TGNSGITWES SHVRHKLARV
LWVPVEGERQ IPLAQRRVGA PLLWSPNEEE EELLRRDWEE LMDLIVLGKV ETITARHGEV
LQLRPKAANS RALTEAIGEH GQPIMTLPRG FYLKKTFTGP MLARHFLL