ID   MUTH_YERP3              Reviewed;         228 AA.
AC   A7FFD6;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-SEP-2007, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=DNA mismatch repair protein MutH {ECO:0000255|HAMAP-Rule:MF_00759};
DE   AltName: Full=Methyl-directed mismatch repair protein {ECO:0000255|HAMAP-Rule:MF_00759};
GN   Name=mutH {ECO:0000255|HAMAP-Rule:MF_00759};
GN   OrderedLocusNames=YpsIP31758_0980;
OS   Yersinia pseudotuberculosis serotype O:1b (strain IP 31758).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=349747;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IP 31758;
RX   PubMed=17784789; DOI=10.1371/journal.pgen.0030142;
RA   Eppinger M., Rosovitz M.J., Fricke W.F., Rasko D.A., Kokorina G.,
RA   Fayolle C., Lindler L.E., Carniel E., Ravel J.;
RT   "The complete genome sequence of Yersinia pseudotuberculosis IP31758, the
RT   causative agent of Far East scarlet-like fever.";
RL   PLoS Genet. 3:1508-1523(2007).
CC   -!- FUNCTION: Sequence-specific endonuclease that cleaves unmethylated GATC
CC       sequences. It is involved in DNA mismatch repair. {ECO:0000255|HAMAP-
CC       Rule:MF_00759}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00759}.
CC   -!- SIMILARITY: Belongs to the MutH family. {ECO:0000255|HAMAP-
CC       Rule:MF_00759}.
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DR   EMBL; CP000720; ABS46433.1; -; Genomic_DNA.
DR   RefSeq; WP_002209838.1; NC_009708.1.
DR   AlphaFoldDB; A7FFD6; -.
DR   SMR; A7FFD6; -.
DR   EnsemblBacteria; ABS46433; ABS46433; YpsIP31758_0980.
DR   GeneID; 57973847; -.
DR   KEGG; ypi:YpsIP31758_0980; -.
DR   HOGENOM; CLU_086669_0_0_6; -.
DR   OMA; EVMQLRP; -.
DR   Proteomes; UP000002412; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006304; P:DNA modification; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   CDD; cd00583; MutH_Sau3AI; 1.
DR   Gene3D; 3.40.600.10; -; 1.
DR   HAMAP; MF_00759; MutH; 1.
DR   InterPro; IPR004230; DNA_mismatch_repair_MutH.
DR   InterPro; IPR011337; DNA_rep_MutH/RE_typeII_Sau3AI.
DR   InterPro; IPR037057; DNA_rep_MutH/T2_RE_sf.
DR   InterPro; IPR011335; Restrct_endonuc-II-like.
DR   Pfam; PF02976; MutH; 1.
DR   SMART; SM00927; MutH; 1.
DR   SUPFAM; SSF52980; SSF52980; 1.
DR   TIGRFAMs; TIGR02248; mutH_TIGR; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA repair; Endonuclease; Hydrolase; Nuclease.
FT   CHAIN           1..228
FT                   /note="DNA mismatch repair protein MutH"
FT                   /id="PRO_1000062206"
SQ   SEQUENCE   228 AA;  25332 MW;  B5B200BA62296443 CRC64;
     MSVYSLPPAP PSDEHQLFQR AQALSGFTLG ELATRAQWVI PADLKRVKGW VGMLLEFYLG
     ASAGSKPEQD FADIGIELKT IPISAQGKPL ETTFVCVAPL TGNSGVTWES SHVRHKLARV
     LWVPVEGERH IPLAERRVGA PLLWSPNVEE EELLRRDWEE LMDLIVLGKV ESITARHGQV
     LQLRPKAANS RALTEAIGEF GQPIMTLPRG FYLKKTLTAP MLARHFLL