ID   MUTL_ACTPJ              Reviewed;         622 AA.
AC   B0BTY3;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=APJL_2005;
OS   Actinobacillus pleuropneumoniae serotype 3 (strain JL03).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Actinobacillus.
OX   NCBI_TaxID=434271;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JL03;
RX   PubMed=18197260; DOI=10.1371/journal.pone.0001450;
RA   Xu Z., Zhou Y., Li L., Zhou R., Xiao S., Wan Y., Zhang S., Wang K., Li W.,
RA   Li L., Jin H., Kang M., Dalai B., Li T., Liu L., Cheng Y., Zhang L., Xu T.,
RA   Zheng H., Pu S., Wang B., Gu W., Zhang X.L., Zhu G.-F., Wang S.,
RA   Zhao G.-P., Chen H.;
RT   "Genome biology of Actinobacillus pleuropneumoniae JL03, an isolate of
RT   serotype 3 prevalent in China.";
RL   PLoS ONE 3:E1450-E1450(2008).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP000687; ABY70550.1; -; Genomic_DNA.
DR   RefSeq; WP_012263464.1; NC_010278.1.
DR   AlphaFoldDB; B0BTY3; -.
DR   SMR; B0BTY3; -.
DR   EnsemblBacteria; ABY70550; ABY70550; APJL_2005.
DR   KEGG; apj:APJL_2005; -.
DR   HOGENOM; CLU_004131_5_1_6; -.
DR   OMA; WKHDDLH; -.
DR   OrthoDB; 764332at2; -.
DR   Proteomes; UP000008547; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair.
FT   CHAIN           1..622
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000096622"
SQ   SEQUENCE   622 AA;  69426 MW;  2DCA6752D47D42E3 CRC64;
     MNKPLIHILP PQLANQIAAG EVVERPASVV KELVENSLDA GANQIQIDIE KGGAQLIRIR
     DNGCGIGKQD LALALARHAT SKISSLEDLE MILSLGFRGE ALASISSVSR LTLTSRPAGQ
     AEAWQAYAQG REMEVEIQPA SHPVGTTIEV ANLFFNTPAR RKFLRTDKTE FTHIDEVVRR
     IALAKPNIGF TLTHNGKTVR QYRKVQDNSV EQQQRRVAAI CGDDFIQNAI HIDWQHGDLH
     LHGWIGLPNI SRPQNDLCYS YVNGRMMRDK TINHAIRQAY EATDMPEGNY PAFVVFLDID
     PSQVDVNVHP AKHEVRFHQG RLVHDFILQG VQTALQGQAE IDLTHQVNEP LPSYQRNTNR
     MAAGGNSFLA SQQAVEFTEN FAKPTASHMP NYSPRTSGVS KSAQKWYGEL VSQPQNQSDN
     IQDLIEPKAN FAPVIFAQEI DEAEPKPTQV VSAAIGHWQP LAIVQNQALL LKAEQQFYLL
     SLEKLARLRF QTQLTKGESQ ALLIPLNLSL DEQQTQRWQT LKTPLAELGF AISEKTWQGQ
     IRLSVTQVPR LLREQNLQQI LLSLFASQAV DLTEFFAKFA PIPTAYSLAE AVNWLAETEQ
     TAKSELEKLK VAVDFSAFLA RC