ID   MUTL_ACTSZ              Reviewed;         637 AA.
AC   A6VN10;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=Asuc_0989;
OS   Actinobacillus succinogenes (strain ATCC 55618 / DSM 22257 / CCUG 43843 /
OS   130Z).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Actinobacillus.
OX   NCBI_TaxID=339671;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 55618 / DSM 22257 / CCUG 43843 / 130Z;
RX   PubMed=21118570; DOI=10.1186/1471-2164-11-680;
RA   McKinlay J.B., Laivenieks M., Schindler B.D., McKinlay A.A.,
RA   Siddaramappa S., Challacombe J.F., Lowry S.R., Clum A., Lapidus A.L.,
RA   Burkhart K.B., Harkins V., Vieille C.;
RT   "A genomic perspective on the potential of Actinobacillus succinogenes for
RT   industrial succinate production.";
RL   BMC Genomics 11:680-680(2010).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP000746; ABR74357.1; -; Genomic_DNA.
DR   RefSeq; WP_012072734.1; NC_009655.1.
DR   AlphaFoldDB; A6VN10; -.
DR   SMR; A6VN10; -.
DR   STRING; 339671.Asuc_0989; -.
DR   EnsemblBacteria; ABR74357; ABR74357; Asuc_0989.
DR   KEGG; asu:Asuc_0989; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_5_1_6; -.
DR   OMA; WKHDDLH; -.
DR   OrthoDB; 764332at2; -.
DR   Proteomes; UP000001114; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..637
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000071502"
SQ   SEQUENCE   637 AA;  71698 MW;  199EF7B2A595B395 CRC64;
     MPIQILPPQL ANQIAAGEVV ERPASVVKEL VENSLDAGAT RIQIDIENGG ATLIRIRDNG
     FGIPKEELSL ALARHATSKI ATIDDLEAIL SFGFRGEALA SISSVSRLTL TSRTADQQEA
     WQVFVQGREQ ESTVNPASHP VGTTVEVANL FFNMPARRKF LRTDKTEFGH IDEVIRRIAL
     AKSHIAFTLT HNGKIVRQYK SAVEDTQKLK RLAAICGNDF VRQALYIDWK HDNLHLSGWV
     TTPTFARQQN DLSYCYVNGR MVKDKVINHA IRQAYAEHLG SERYPAFVLF LDLNPNDVDV
     NVHPTKHEVR FQQSRLIHDF IFQGVTNALL SAEQFDFSAS TESEKNNEIR EPQADYQNVT
     PTIRPNRAAA GQNMFELNSP TQTKQTNVPI TTKAYPTPAH SGQAGYSTTP SNPPPHFMPQ
     SARSVSPFER EKVTKTEQRI YAELLKTPEV EAPPTSIQSS LLSSSSLLHA VALVNNQALL
     LQRDTAFYLL PLNKLQKMRL ELLLTLPNTP QQMLLIPVVF RLSDKQQAQW RQQKIWFEQS
     GFEFIENPVQ HRITLNAVPQ CLRHQNLQKI VIALLNRSLQ KTEKFLTALL DLVELPDCQV
     LANAVNILQE TELLLDQQTT MKLDNLLIPI DFSSYLS