ID   MUTL_AERHH              Reviewed;         622 AA.
AC   A0KGR9;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   12-DEC-2006, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=AHA_0922;
OS   Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / DSM 30187 / BCRC
OS   13018 / CCUG 14551 / JCM 1027 / KCTC 2358 / NCIMB 9240 / NCTC 8049).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Aeromonadales;
OC   Aeromonadaceae; Aeromonas.
OX   NCBI_TaxID=380703;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 7966 / DSM 30187 / BCRC 13018 / CCUG 14551 / JCM 1027 / KCTC
RC   2358 / NCIMB 9240 / NCTC 8049;
RX   PubMed=16980456; DOI=10.1128/jb.00621-06;
RA   Seshadri R., Joseph S.W., Chopra A.K., Sha J., Shaw J., Graf J., Haft D.H.,
RA   Wu M., Ren Q., Rosovitz M.J., Madupu R., Tallon L., Kim M., Jin S.,
RA   Vuong H., Stine O.C., Ali A., Horneman A.J., Heidelberg J.F.;
RT   "Genome sequence of Aeromonas hydrophila ATCC 7966T: jack of all trades.";
RL   J. Bacteriol. 188:8272-8282(2006).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP000462; ABK36247.1; -; Genomic_DNA.
DR   RefSeq; WP_011704862.1; NC_008570.1.
DR   RefSeq; YP_855465.1; NC_008570.1.
DR   AlphaFoldDB; A0KGR9; -.
DR   SMR; A0KGR9; -.
DR   STRING; 380703.AHA_0922; -.
DR   EnsemblBacteria; ABK36247; ABK36247; AHA_0922.
DR   KEGG; aha:AHA_0922; -.
DR   PATRIC; fig|380703.7.peg.922; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_5_1_6; -.
DR   OMA; DLQYTYV; -.
DR   Proteomes; UP000000756; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..622
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000009972"
FT   REGION          376..401
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   622 AA;  68884 MW;  629FD61F4C6E375F CRC64;
     MPIRILPPIL ANQIAAGEVV ERPSSVVKEL VENSLDAGAD RVEIDIDKGG AKLIRIRDNG
     SGVAKDELVL ALSRHATSKV ATLDDLEGIN SLGFRGEALA SISSVSRLTF TSRTAEQSEA
     WQAQAEGREM SVTIKPAAHP VGTTVEVVDL FFNTPARRKF MRSEKTEFAH IDELVRRIAL
     SRFDVTLILR HNGKVVRQYK AANTVAEQER RLAAVCGSPF MHYALAVESE HSDVRLWGWL
     ATPEGARPQN DLQYTYVNGR MMRDKLINHA IRQAYDELLP ADRFAAYVLY IELDPRQVDV
     NVHPAKHEVR FHQARLIHDF IFQALFTALR QQGAASDEPL AETLVELPVS APIEYPGQAP
     RAEWYGAEHN YRAPAREVRE GSSTGRAGNY QPPEPPSREA MRGMGSLLTT LPAVQGTPLA
     EAETAPVAAA VPAKAGAWRA LTLVEQAYLL LERDNRLALL SLVRAERLLL RHWLLETWGQ
     GLAAQPLLLP VSFKLPKNLV ALVEQQDRLL KRMGLELKSG GRDTMILTRV PALLRQTDLV
     RLLPELLQLI ESGSDSDAGQ QAEVLCQWLV EQGISREKVY DFATANRLLT ELVADFSDQL
     ANVRMVRPLA LASVLAEFAD GH