ID   MUTL_AERS4              Reviewed;         627 AA.
AC   A4SR27;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=ASA_3371;
OS   Aeromonas salmonicida (strain A449).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Aeromonadales;
OC   Aeromonadaceae; Aeromonas.
OX   NCBI_TaxID=382245;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=A449;
RX   PubMed=18801193; DOI=10.1186/1471-2164-9-427;
RA   Reith M.E., Singh R.K., Curtis B., Boyd J.M., Bouevitch A., Kimball J.,
RA   Munholland J., Murphy C., Sarty D., Williams J., Nash J.H., Johnson S.C.,
RA   Brown L.L.;
RT   "The genome of Aeromonas salmonicida subsp. salmonicida A449: insights into
RT   the evolution of a fish pathogen.";
RL   BMC Genomics 9:427-427(2008).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP000644; ABO91349.1; -; Genomic_DNA.
DR   RefSeq; WP_005311659.1; NC_009348.1.
DR   AlphaFoldDB; A4SR27; -.
DR   SMR; A4SR27; -.
DR   STRING; 382245.ASA_3371; -.
DR   EnsemblBacteria; ABO91349; ABO91349; ASA_3371.
DR   KEGG; asa:ASA_3371; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_5_1_6; -.
DR   OMA; DLQYTYV; -.
DR   OrthoDB; 764332at2; -.
DR   Proteomes; UP000000225; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair.
FT   CHAIN           1..627
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000009973"
FT   REGION          376..404
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   627 AA;  69252 MW;  AAB3A89A6A7747B4 CRC64;
     MPIRILPPIL ANQIAAGEVV ERPSSVVKEL VENSLDAGAD RVEIDIDKGG AKLIRIRDNG
     CGVAKDELVL ALSRHATSKV ATLDDLEGIC SLGFRGEALA SISSVSRLTF TSRTQDQSEA
     WQAQAEGREM NVTVKPAAHP VGTTVEVVDL FFNTPARRKF MRSEKTEFAH IDELVRRIAL
     SRFDVTLILR HNGKVMRQYK AANTVAEQER RLAAVCGTPF MHHALAVESE HSDVRLWGWL
     ALPEGARPQN DLQYTYVNGR MMRDKLINHA IRQAYDELLP TDRFAAYVLY IELDPHQVDV
     NVHPAKHEVR FHQARLIHDF IFQALFTALR REGVSAAHQE EPLAETLVEL PVSGQIEYPG
     QAPRPEWYGA EHSYRAPAST NEVREGSAAR AGNYQPPEPP SREAMRSMGA LLTTLPGAGP
     ASAASATAAM VPSAAAQTAP GVWQALTLVE QAYLLLVRDG QLALLSLVRA ERLLLRNWLL
     EAWGQGLAAQ PLLLPVSFKL PKNLIALVEA QERLLKRMGL ELKSGGRDTM ILTRVPALLR
     QTDLVRLLPE LLQIIESGSD SDASQLAEVL CQWLVEQGIS HEKIYDFSTA NRLLTELVAD
     FSDQLADIRM VRPVSLTTVL EAFAHDG