ID   MUTL_AFIC5              Reviewed;         612 AA.
AC   B6JIV1; F8BZU0;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   OrderedLocusNames=OCAR_7241, OCA5_c08730;
OS   Afipia carboxidovorans (strain ATCC 49405 / DSM 1227 / KCTC 32145 / OM5)
OS   (Oligotropha carboxidovorans).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Bradyrhizobiaceae; Afipia.
OX   NCBI_TaxID=504832;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 49405 / DSM 1227 / KCTC 32145 / OM5;
RX   PubMed=18539730; DOI=10.1128/jb.00614-08;
RA   Paul D., Bridges S., Burgess S.C., Dandass Y., Lawrence M.L.;
RT   "Genome sequence of the chemolithoautotrophic bacterium Oligotropha
RT   carboxidovorans OM5T.";
RL   J. Bacteriol. 190:5531-5532(2008).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 49405 / DSM 1227 / KCTC 32145 / OM5;
RX   PubMed=21742883; DOI=10.1128/jb.05619-11;
RA   Volland S., Rachinger M., Strittmatter A., Daniel R., Gottschalk G.,
RA   Meyer O.;
RT   "Complete genome sequences of the chemolithoautotrophic Oligotropha
RT   carboxidovorans strains OM4 and OM5.";
RL   J. Bacteriol. 193:5043-5043(2011).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP001196; ACI94345.1; -; Genomic_DNA.
DR   EMBL; CP002826; AEI05595.1; -; Genomic_DNA.
DR   RefSeq; WP_012564371.1; NC_015684.1.
DR   AlphaFoldDB; B6JIV1; -.
DR   SMR; B6JIV1; -.
DR   STRING; 504832.OCAR_7241; -.
DR   EnsemblBacteria; AEI05595; AEI05595; OCA5_c08730.
DR   KEGG; oca:OCAR_7241; -.
DR   KEGG; ocg:OCA5_c08730; -.
DR   PATRIC; fig|504832.7.peg.923; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_2_5; -.
DR   OMA; AHERIMY; -.
DR   OrthoDB; 764332at2; -.
DR   Proteomes; UP000007730; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..612
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000096668"
SQ   SEQUENCE   612 AA;  66004 MW;  12B324B87B7376C0 CRC64;
     MPVRQLPEQI VNRIAAGEVV ERPASAVKEL VENAIDAGGT RIDIFTEGGG RRRIVITDDG
     SGMTQGDLAL AVERHATSKL DDEDLLRIRT LGFRGEALPS ISSVAKLAIT TRHAAEPHAW
     AVEVDAGAKS AIAPAALQRG TRVEVSDLFY ATPARLKFLK TDRTEAEAIR EVVRRLAMAR
     PDIAFTLAGE ERAPVTWAAA LPGAPGRLTR LGDILGSDFR THAIEVGSER EGVSVEGFAA
     APSLTRANAL GQYLFVNGRP VRDKLILGAV RAAYADYLPR DRHPIVALFV TLDPQEVDAN
     VHPAKTEVRF RNAGLVRALI VHALKDGLAR EGRRTAANTN GAAITTAFRT EGFSREGFAR
     ESLPRGGYDW RSSPAAPWPP QAAAQAPAMG FDESAQAAFD AGAPSADTRG NEAPLGDALG
     RPLGAARTQI HENYIVAQTN DGLILVDQHA AHERIVYERL KASLTKNGVA RQMLLIPEIV
     EMDEASVEKL LARASELEKY GLSIESFGPG AVAVRETPAL LGKANAASLL RDLAEHMAEW
     DEALPLERRL MHVAATMACH GSVRSGRILK VEEMNALLRE MEATPNSGQC NHGRPTYVEL
     KLADIEKLFG RR