ID   MUTL_AGARV              Reviewed;         648 AA.
AC   C4ZA52;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=EUBREC_1749;
OS   Agathobacter rectalis (strain ATCC 33656 / DSM 3377 / JCM 17463 / KCTC 5835
OS   / VPI 0990) (Eubacterium rectale).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Lachnospiraceae;
OC   Lachnospiraceae incertae sedis.
OX   NCBI_TaxID=515619;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 33656 / DSM 3377 / JCM 17463 / KCTC 5835 / LMG 30912 / VPI
RC   0990;
RX   PubMed=19321416; DOI=10.1073/pnas.0901529106;
RA   Mahowald M.A., Rey F.E., Seedorf H., Turnbaugh P.J., Fulton R.S.,
RA   Wollam A., Shah N., Wang C., Magrini V., Wilson R.K., Cantarel B.L.,
RA   Coutinho P.M., Henrissat B., Crock L.W., Russell A., Verberkmoes N.C.,
RA   Hettich R.L., Gordon J.I.;
RT   "Characterizing a model human gut microbiota composed of members of its two
RT   dominant bacterial phyla.";
RL   Proc. Natl. Acad. Sci. U.S.A. 106:5859-5864(2009).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP001107; ACR75493.1; -; Genomic_DNA.
DR   RefSeq; WP_012742591.1; NC_012781.1.
DR   AlphaFoldDB; C4ZA52; -.
DR   SMR; C4ZA52; -.
DR   STRING; 515619.EUBREC_1749; -.
DR   PRIDE; C4ZA52; -.
DR   EnsemblBacteria; ACR75493; ACR75493; EUBREC_1749.
DR   KEGG; ere:EUBREC_1749; -.
DR   HOGENOM; CLU_004131_4_1_9; -.
DR   OMA; AHERIMY; -.
DR   OrthoDB; 764332at2; -.
DR   Proteomes; UP000001477; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..648
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000203386"
FT   REGION          385..430
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        385..426
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   648 AA;  73336 MW;  9A303733B68915A0 CRC64;
     MPNIAILNQE TIDKIAAGEV VERPCSVVKE LVENAIDAGS TAITVEIKEG GISFIRITDN
     GCGIERDQVA VAFYRHSTSK IRSAEDLLTV KSLGFRGEAL SSISAVARVE LITKTYDELT
     GTRYVIEGSK ELSNEEIGAP DGTTFIVKDL FYNVPARRKF LKTAQTEGSY ISDMVEKLAL
     SHPDISFKFI NNNQTKLHTS GNGNRKDIIY HIFGREISSS LLEVKHECEY FKVEGFIGKP
     VITRGNRNYE NYFINGRYVK SNILSRAIEE AYKSFLMQHQ YPFTVLYFTF FSELDVNVHP
     TKMELRFDNN NEIYVELCDT IYAILAHKEM IPEVPVDSTP APKKIVHEYK EPIPEPFEKR
     RINEVRAAES RSVYGQSVTA TVKSSTVKGP AVNEPLTENT LNQQKVKTSA STPVVHTGNS
     VEPKPETSTA YEPAHVVTGT QQTLGDYDKV FLTESAKKQF SIIGQLFKTY WLIEFEDKLY
     IIDQHAAHEK VLYEKTMARL ANKDFTSQRI SPPIVMTLDA RECEMLEKYR PQIEQFGYEV
     EHFGGKEYMI SAIPDNLFNI DMKDLFIEML DDFSNATGRQ TPDIITEKVA SMSCKAAVKG
     NDKLTLPEIN KLIDELLSLD NPYNCPHGRP TIISMSKYEI EKKFKRIV