ID   MUTL_AKKM8              Reviewed;         633 AA.
AC   B2ULE2;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-2008, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=Amuc_0086;
OS   Akkermansia muciniphila (strain ATCC BAA-835 / DSM 22959 / JCM 33894 / BCRC
OS   81048 / CCUG 64013 / CIP 107961 / Muc).
OC   Bacteria; Verrucomicrobia; Verrucomicrobiae; Verrucomicrobiales;
OC   Akkermansiaceae; Akkermansia.
OX   NCBI_TaxID=349741;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-835 / DSM 22959 / JCM 33894 / BCRC 81048 / CCUG 64013 / CIP
RC   107961 / Muc;
RX   PubMed=21390229; DOI=10.1371/journal.pone.0016876;
RA   van Passel M.W., Kant R., Zoetendal E.G., Plugge C.M., Derrien M.,
RA   Malfatti S.A., Chain P.S., Woyke T., Palva A., de Vos W.M., Smidt H.;
RT   "The genome of Akkermansia muciniphila, a dedicated intestinal mucin
RT   degrader, and its use in exploring intestinal metagenomes.";
RL   PLoS ONE 6:E16876-E16876(2011).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP001071; ACD03931.1; -; Genomic_DNA.
DR   RefSeq; WP_012419146.1; NC_010655.1.
DR   AlphaFoldDB; B2ULE2; -.
DR   SMR; B2ULE2; -.
DR   STRING; 349741.Amuc_0086; -.
DR   PRIDE; B2ULE2; -.
DR   EnsemblBacteria; ACD03931; ACD03931; Amuc_0086.
DR   KEGG; amu:Amuc_0086; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_2_0; -.
DR   OMA; AHERIMY; -.
DR   OrthoDB; 764332at2; -.
DR   BioCyc; AMUC349741:G1GBX-106-MON; -.
DR   Proteomes; UP000001031; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..633
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000096623"
FT   REGION          338..407
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        382..396
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   633 AA;  69554 MW;  1357E9FE7DBB54BE CRC64;
     MPSIHVMSPT LASQVAAGEV VERPASVVKE LVENSLDAGA KFVRVEIRRG GVGMIKVTDD
     GSGMSRADAE LCTKRHATSK LSSLEELFEI THLGFRGEAL PSIASVSRFK LCTRQQQDLE
     GWEIRIDGGL EHEPRSSGVS PGTAIEVADL FYNTPARRKF LKSAETEASH VEHQIRLHAL
     AYPQVRFAYK RDDQLVFDLP ATADLRVRIS ALTDAATAAA LIPIETTIGP GISITGFLLP
     LSEARRTRKG QYVFMNTRPV EDQLINRAIR DGYGGFPTGL HPALFLYMEV EPALVDVNVH
     PAKKEVRFRR SADVVNTIVE AIANTLQKHA RQEIHAAAAP EPERTLPPAH STTAPYGEIP
     ARSTNPGSAF PAAARPAPAS SAAQPPLSSS AKQSHGAVPP PTLRAIPLKQ VPATQGKLDF
     HRQEDEETAR NAHENAALER DASAGFSYLG TLRQQFALFE TPEGLVLMHP KAARERIIFE
     RLRARREAPM PSQQLLDPVV LDLDPRDFAV IRQFAPHFDQ AGMAVTPFGQ NTIRIESIPA
     LLELENARAF LLELVDRLTQ SEFSRNAKRV AYETFIGEFA RKSAWRERIS PHRAPAILKD
     LLACEVPYCT PGGKPTLVNY SVPEIKRKFG LQA