ID   MUTL_ALIF1              Reviewed;         660 AA.
AC   Q5E2C6;
DT   02-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=VF_2325;
OS   Aliivibrio fischeri (strain ATCC 700601 / ES114) (Vibrio fischeri).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Aliivibrio.
OX   NCBI_TaxID=312309;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700601 / ES114;
RX   PubMed=15703294; DOI=10.1073/pnas.0409900102;
RA   Ruby E.G., Urbanowski M., Campbell J., Dunn A., Faini M., Gunsalus R.,
RA   Lostroh P., Lupp C., McCann J., Millikan D., Schaefer A., Stabb E.,
RA   Stevens A., Visick K., Whistler C., Greenberg E.P.;
RT   "Complete genome sequence of Vibrio fischeri: a symbiotic bacterium with
RT   pathogenic congeners.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:3004-3009(2005).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000020; AAW86820.1; -; Genomic_DNA.
DR   RefSeq; WP_011262727.1; NC_006840.2.
DR   RefSeq; YP_205708.1; NC_006840.2.
DR   AlphaFoldDB; Q5E2C6; -.
DR   SMR; Q5E2C6; -.
DR   STRING; 312309.VF_2325; -.
DR   EnsemblBacteria; AAW86820; AAW86820; VF_2325.
DR   KEGG; vfi:VF_2325; -.
DR   PATRIC; fig|312309.11.peg.2364; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_5_1_6; -.
DR   OMA; ATQEQAW; -.
DR   OrthoDB; 764332at2; -.
DR   Proteomes; UP000000537; Chromosome I.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..660
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_0000177990"
FT   REGION          368..426
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          439..461
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        369..385
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        401..426
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   660 AA;  74083 MW;  5D7FCF15006FD27B CRC64;
     MPIQILPARL ANQIAAGEVV ERPASVVKEL VENSIDAGAT RIDIDIEKGG SKLIRIRDNG
     SGIPKDELTL ALSRHATSKI TSLDDLEAIV SLGFRGEALA SISSVSRLTL TSRTVAQEEA
     WSAYAEGREM NVKLKPAAHP IGTTIDVVDL FFNTPARRKF LRADKTEFTH IDELLKRIAL
     SRLDVTINLR HNGKMVRQYR AAQTKPQIEK RLAAVCGANF LQHALEVELE HGELKFHGWI
     SSPEGARAQG DIQYCYVNGR MMKDKLINHA IRQGYESSLP ANQYAAYILF IEINPHDVDV
     NVHPAKHEVR FHQARLVHDF IYQAIFGALQ QGASLPDVVG HIQSEAEEQQ LESKESYFPP
     MKEYVRQPQQ THYPKSEQLR AAVESTPSYP NKAPLDSWIP KGNVGSSSSN STAPSRSFHT
     DKPTKKALSN YNELLTTQNR EQRESTSQVN EQSHTFRSTQ QIERVAPQVT QVSKNGITLG
     KVLSVVESTF ALLQQGKQLQ LLNLRYAEFV KIYGQLSSVN VEPLKPQPLL IPLSVGIDES
     ICNNLSNYAS LLKSLGIDLK VKNRTNIIVM AVCQPIRQQN LQQLIPNLLR YLEQINPSLE
     QVIKWLSHQI QHDEVSYTTA QAIQLVMELE QLWGDELNNF YPKLLKDIDI TQVIQAFSHE