ID   MUTL_ALIFM              Reviewed;         661 AA.
AC   B5FBR6;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   14-OCT-2008, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=VFMJ11_2438;
OS   Aliivibrio fischeri (strain MJ11) (Vibrio fischeri).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Aliivibrio.
OX   NCBI_TaxID=388396;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MJ11;
RA   Mandel M.J., Stabb E.V., Ruby E.G., Ferriera S., Johnson J., Kravitz S.,
RA   Beeson K., Sutton G., Rogers Y.-H., Friedman R., Frazier M., Venter J.C.;
RT   "Complete sequence of Vibrio fischeri strain MJ11.";
RL   Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP001139; ACH65712.1; -; Genomic_DNA.
DR   RefSeq; WP_012533237.1; NC_011184.1.
DR   AlphaFoldDB; B5FBR6; -.
DR   SMR; B5FBR6; -.
DR   EnsemblBacteria; ACH65712; ACH65712; VFMJ11_2438.
DR   KEGG; vfm:VFMJ11_2438; -.
DR   HOGENOM; CLU_004131_5_1_6; -.
DR   OMA; ATQEQAW; -.
DR   Proteomes; UP000001857; Chromosome I.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair.
FT   CHAIN           1..661
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000096699"
FT   REGION          367..424
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        369..385
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        397..416
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   661 AA;  74145 MW;  23AAA8AB08731285 CRC64;
     MPIQILPARL ANQIAAGEVV ERPASVVKEL VENSIDAGAT RIDIDIEKGG SKLIRIRDNG
     SGIPKDELTL ALSRHATSKI TSLDDLEAIV SLGFRGEALA SISSVSRLTL TSRTVAQEEA
     WSAYAEGREM NVKLKPAAHP IGTTIDVVDL FFNTPARRKF LRADKTEFTH IDELLKRIAL
     SRLDVTINLR HNGKMVRQYR AAQTKPQIEK RLAAVCGANF LQHALEVELE HGELKFHGWI
     SSPEGARAQG DIQYCYVNGR MMKDKLINHA IRQGYESSLP ANQYAAYILF IEINPHDVDV
     NVHPAKHEVR FHQARLVHDF IYQAIFGALQ QGASLSNVVC NDQPLVEEQV IENKESYFPP
     MKEYVRQPQQ SHYPKSEQLR VAVESTPSYP NKAPLDSWIP KSSTGNSSSK PSALPRSFHN
     NDKPAEKALS NYNELLTTQS RVQRESSSQV NEQSLTFSTT QQIERVAPQV THVSKNDITL
     GKVLSVVEST FALLQQGKQL QLLNLRYAEF VKTYGQLSSV NVEPLKPQPL LIPLSVGIDE
     SICNNLSNYA SLLKSLGIDL KVKNRTNIIV MAVCQPIRQQ NLQQLIPNLL RYLEQINPSL
     EQVIKWLSHQ IQHDEVSYTT AQAIQLVMEL EQLWGGKLND FYPKLLKDID ITQVIQAFSH
     E