ID   MUTL_ALISL              Reviewed;         652 AA.
AC   B6EMQ9;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   25-NOV-2008, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=VSAL_I2779;
OS   Aliivibrio salmonicida (strain LFI1238) (Vibrio salmonicida (strain
OS   LFI1238)).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Aliivibrio.
OX   NCBI_TaxID=316275;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LFI1238;
RX   PubMed=19099551; DOI=10.1186/1471-2164-9-616;
RA   Hjerde E., Lorentzen M.S., Holden M.T., Seeger K., Paulsen S., Bason N.,
RA   Churcher C., Harris D., Norbertczak H., Quail M.A., Sanders S.,
RA   Thurston S., Parkhill J., Willassen N.P., Thomson N.R.;
RT   "The genome sequence of the fish pathogen Aliivibrio salmonicida strain
RT   LFI1238 shows extensive evidence of gene decay.";
RL   BMC Genomics 9:616-616(2008).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; FM178379; CAQ80463.1; -; Genomic_DNA.
DR   RefSeq; WP_012551215.1; NC_011312.1.
DR   AlphaFoldDB; B6EMQ9; -.
DR   SMR; B6EMQ9; -.
DR   STRING; 316275.VSAL_I2779; -.
DR   PRIDE; B6EMQ9; -.
DR   EnsemblBacteria; CAQ80463; CAQ80463; VSAL_I2779.
DR   KEGG; vsa:VSAL_I2779; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_5_1_6; -.
DR   OMA; ATQEQAW; -.
DR   OrthoDB; 764332at2; -.
DR   Proteomes; UP000001730; Chromosome 1.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair.
FT   CHAIN           1..652
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000096624"
SQ   SEQUENCE   652 AA;  73307 MW;  95FF5CA3714227A1 CRC64;
     MPIQILPARL ANQIAAGEVV ERPASVVKEL VENSIDAGAT RIDIDIEKGG SKLIRIRDNG
     SGIPKEELTL ALSRHATSKI TTLDDLEAIV SLGFRGEALA SISSVSRLTL TSRTVAQEEA
     WSAHAEGRDM EVKLKPAAHP VGTTIDVVDL FFNTPARRKF LRTDKTEFTH IDELLKRIAL
     SRLDITINLR HNGKSVRQYR AAQTKMQVEK RLAAVCGASF LQHALEVELE HGDLIFHGWI
     SSPEGARAQG DVQYCYVNGR MMKDKLINHA IRQGYESSLS TNQYAAYILF IEINPHDVDV
     NVHPAKHEVR FHQARLVHDF IYQAIYGALQ QAASLPEVTT TSDIEMDRES YFPPMKDYVR
     QSSLPLTDAH IENKSKQLKE AIEATPSYPN KASSDEWVSK AKPSMPKAYQ SEKPSQRELN
     NYQHLLTTRD REDKTSNFEV NEVRIPKISE AKHNTVVVPQ LKSAVSTSML LGKVLSVVDK
     VFGLLQLGNQ LQLVDLRYAE FIKSYGQLNS AHHEVLKAQP LLIPLSIGID KDICNKLTEY
     QGILKQLGID LKVKNNESLI VMAVCQPIRQ QNLQQLIPNL LRYIYQINPS LDQVISWLSH
     QVQHDEACYS SAQAIQLVME LEQLWGNELS QFNNKLLKNI DITQAIQAFS HE