ID   MUTL_ALKCK              Reviewed;         654 AA.
AC   Q5WFY4;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=ABC2186;
OS   Alkalihalobacillus clausii (strain KSM-K16) (Bacillus clausii).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Alkalihalobacillus.
OX   NCBI_TaxID=66692;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KSM-K16;
RA   Takaki Y., Kageyama Y., Shimamura S., Suzuki H., Nishi S., Hatada Y.,
RA   Kawai S., Ito S., Horikoshi K.;
RT   "The complete genome sequence of the alkaliphilic Bacillus clausii KSM-
RT   K16.";
RL   Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; AP006627; BAD64721.1; -; Genomic_DNA.
DR   RefSeq; WP_011247029.1; NC_006582.1.
DR   AlphaFoldDB; Q5WFY4; -.
DR   SMR; Q5WFY4; -.
DR   STRING; 66692.ABC2186; -.
DR   PRIDE; Q5WFY4; -.
DR   EnsemblBacteria; BAD64721; BAD64721; ABC2186.
DR   KEGG; bcl:ABC2186; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_1_9; -.
DR   OMA; AHERIMY; -.
DR   OrthoDB; 764332at2; -.
DR   Proteomes; UP000001168; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..654
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000009983"
FT   REGION          358..437
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        416..437
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   654 AA;  73639 MW;  9D7461AD45A88813 CRC64;
     MAVIQQLDDA LSNKIAAGEV VERPASIVKE LVENAIDANS SQILVEIEEG GLSSIRIVDN
     GTGIEPNELE LAFSRHATSK IKTDRDLFTI CTLGFRGEAL PSIASVSRVN MQTSTGSAGM
     QVELEGGKIV HKQPSEARKG TTIVVTDLFY NTPARLKYLK TVLTEAGHVS EVMNRMALAY
     PHIRFHYVSD GKTVLKTAGN GDLRQVIAQV YGRKTAEKMV PITGSSLDYE LRGYIAKPEL
     TRANRQYMSI FINGRYIRNF KLAKAIQQGF HTKLPIGRFP IAVLKLEMDP TLIDVNVHPA
     KLEVRLSKEE ALSEMIAESI KKALSEETLI PEPKKENTAK TKSEQLSFSL AYELQPEKEH
     VRETMQQPRQ LAADDQVDRK KESTSIGNSW SPSHQQEEEV EQGRGSNASI PPRNERVETN
     TEEKYEQADR RTDESLPMEM EEEAAVVEPQ LPLGNDAEAK GAMPPLYPVG QMHGTYIVAQ
     NEQGMYLIDQ HAAQERIKYE HFHQKLAEPL GQTQELLVPI TLELTTRETL VVTESKEKLE
     AVGVFLEEFG KNTFVVRSHP TWFPQGDEES TIREMVEQLL DNKRISIGEL REEAAIMMSC
     KAAIKANRHL RTDEMFQLLE TLRRCQEPYT CPHGRPVVIH FSTYELEKMF KRVM